ReviewCurrent rheumatology reports2015
Bone Homeostasis and Repair: Forced Into Shape.
Review in Current rheumatology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed.
- Porous metal block based on topology optimization to treat distal femoral bone defect in total knee revision.Biomechanics and modeling in mechanobiology · 2023Article
- Skeletal adaptation to mechanical cues during homeostasis and repair: the niche, cells, and molecular signaling.Frontiers in physiology · 2023Review
- Cranial Bone Changes Induced by Mild Traumatic Brain Injuries: A Neglected Player in Concussion Outcomes?Neurotrauma reports · 2023Article
- Molecular mechanisms of exercise contributing to tissue regeneration.Signal transduction and targeted therapy · 2022Review
- Localized, time-dependent responses of rat cranial bone to repeated mild traumatic brain injuries.Scientific reports · 2022Article
- Periprosthetic Osteolysis: Mechanisms, Prevention and Treatment.Journal of clinical medicine · 2019Review
- Mechanical strain determines the site-specific localization of inflammation and tissue damage in arthritis.Nature communications · 2018Article
- Investigating the mechanistic basis of biomechanical input controlling skeletal development: exploring the interplay with Wnt signalling at the joint.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018Article
- [A new continuous gait analysis system for ankle fracture aftercare].Der Unfallchirurg · 2018Article
- Osteoblast-derived paracrine factors regulate angiogenesis in response to mechanical stimulation.Integrative biology : quantitative biosciences from nano to macro · 2016Article
- Concise Review: Plasma and Nuclear Membranes Convey Mechanical Information to Regulate Mesenchymal Stem Cell Lineage.Stem cells (Dayton, Ohio) · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
Mechanical loading is a potent anabolic regulator of bone mass, and the first line of defense for bone loss is weight-bearing exercise. Likewise, protected weight bearing is the first prescribed physical therapy following orthopedic reconstructive surgery. In both cases, enhancement of new bone formation is the goal. Our understanding of the physical cues, mechanisms of force sensation, and the subsequent cellular response will help identify novel physical and therapeutic treatments for age- and disuse-related bone loss, delayed- and nonunion fractures, and significant bony defects. This review highlights important new insights into the principles and mechanisms governing mechanical adaptation of the skeleton during homeostasis and repair and ends with a summary of clinical implications stemming from our current understanding of how bone adapts to biophysical force.
Indexed as
Identifiers
26233599What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.