Evidence map›Paper›PMID 26233594›Full record

Trial reportKnee surgery, sports traumatology, arthroscopy : official journal of the ESSKA2017

Multiple PRP injections are more effective than single injections and hyaluronic acid in knees with early osteoarthritis: a randomized, double-blind, placebo-controlled trial.

Gökay Görmeli, Cemile Ayşe Görmeli, Baybars Ataoglu, Cemil Çolak, Okan Aslantürk, Kadir Ertem

5 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 173 papers, 30 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
173citing papers in PubMed, 30 pooled it
27.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04351087 nacompletednot on this mapstarted 2020, after this paper: background citation

Microfragmented Adipose Tissue Versus Platelet-rich Plasma for Knee Osteoarthritis: a Randomized Comparative Trial

TypeinterventionalSponsorOhio State UniversityRan2020 to 2022Enrolled79ConditionsOsteoarthritis, Knee, Microfragmented Adipose Tissue, Platelet-Rich PlasmaArmsPlatelet Rich Plasma
NCT04454164 early_phase1completednot on this mapstarted 2018, after this paper: background citation

Platelet Rich Plasma In Knee Osteoarthritis: A Prospective, Double-Blind Randomized, Placebo Controlled Clinical Trial

TypeinterventionalSponsorFerhat SayRan2018 to 2020Enrolled324ConditionsKnee Osteoarthritis, Cartilage DegenerationArmsPRP, Saline
NCT05080075 early_phase1completednot on this mapstarted 2021, after this paper: background citation

Platelet Rich Plasma in Knee Osteoarthritis: Establishing Clinical Guidelines to Predict and Maximize Outcomes

TypeinterventionalSponsorUniversity of Toledo Health Science CampusRan2021 to 2023Enrolled33ConditionsKnee OsteoarthritisArmsPlatelet Rich Plasma Injection
NCT06032039 early_phase1unknown statusnot on this mapstarted 2023, after this paper: background citation

Corticosteroid vs Platelet-Rich Plasma Intra-articular Injections in the Treatment of Knee Osteoarthritis in Patients Fifty Years and Older: a Look at Pain and Functional Outcomes at a Single Institution.

TypeinterventionalSponsorThe University of The West IndiesRan2023 to 2025Enrolled160ConditionsKnee OsteoarthritisArmsTriamcinolone, Platelet Rich Plasma
NCT07016672 narecruitingnot on this mapstarted 2025, after this paper: background citation

Efficacy of Therapy With Intra-articular Injections of PRP Compared With Therapy With Intra-articular Injections of HA, in Patients With Grade III or IV GONArthrosis: a Prospective Randomized Open-label Study

TypeinterventionalSponsorCentre Hospitalier Intercommunal de Toulon La Seyne sur MerRan2025 to 2028Enrolled150ConditionsKnee OsteoarthritisArmsintra-articular injection of HA, intra-articular injection of PRP
3 · Its place in the literature

Who cites it

173 citing papers in PubMed, 30 syntheses or guidelines pooled it, 393 citations in OpenAlex.

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113 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Gökay GörmeliDepartment of Orthopedics and Traumatology, Turgut Ozal Medical School, Inonu University, Malatya, Turkey. ggormeli@gmail.com.
Cemile Ayşe GörmeliDepartment of Radiology, Turgut Ozal Medical School, Inonu University, Malatya, Turkey.
Baybars AtaogluDepartment of Orthopedics and Traumatology, Gazi University, Ankara, Turkey.
Cemil ÇolakDepartment of Biostatistics, Turgut Ozal Medical School, Inonu University, Malatya, Turkey.
Okan AslantürkDepartment of Orthopedics and Traumatology, Turgut Ozal Medical School, Inonu University, Malatya, Turkey.
Kadir ErtemDepartment of Orthopedics and Traumatology, Turgut Ozal Medical School, Inonu University, Malatya, Turkey.
Inonu University · TRGazi University · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo compare the effectiveness of intraarticular (IA) multiple and single platelet-rich plasma (PRP) injections as well as hyaluronic acid (HA) injections in different stages of osteoarthritis (OA) of the knee.

methodsA total of 162 patients with different stages of knee OA were randomly divided into four groups receiving 3 IA doses of PRP, one dose of PRP, one dose of HA or a saline injection (control). Then, each group was subdivided into two groups: early OA (Kellgren-Lawrence grade 0 with cartilage degeneration or grade I-III) and advanced OA (Kellgren-Lawrence grade IV). The patients were evaluated before the injection and at the 6-month follow-ups using the EuroQol visual analogue scale (EQ-VAS) and International Knee Documentation Committee (IKDC) subjective scores. Adverse events and patient satisfaction were recorded.

resultsThere was a statistically significant improvement in the IKDC and EQ-VAS scores in all the treatment groups compared with the control group. The knee scores of patients treated with three PRP injections were significantly better than those patients of the other groups. There was no significant difference in the scores of patients injected with one dose of PRP or HA. In the early OA subgroups, significantly better clinical results were achieved in the patients treated with three PRP injections, but there was no significant difference in the clinical results of patients with advanced OA among the treatment groups.

conclusionThe clinical results of this study suggest IA PRP and HA treatment for all stages of knee OA. For patients with early OA, multiple (3) PRP injections are useful in achieving better clinical results. For patients with advanced OA, multiple injections do not significantly improve the results of patients in any group. LEVEL OF EVIDENCE: I.

Indexed as

Platelet-Rich PlasmaDouble-Blind MethodFemaleHumansHyaluronic AcidInjections, Intra-ArticularMaleMiddle AgedOsteoarthritis, KneePain MeasurementPatient SatisfactionTreatment OutcomeViscosupplementsHyaluronic AcidViscosupplementsHyaluronic acidIntraarticular injectionKnee osteoarthritisPlatelet-rich plasma

Identifiers

PMID26233594
OpenAlexW1031259716

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.