ArticleDrug and alcohol dependence2015
Variations in opioid receptor genes in neonatal abstinence syndrome.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 63 citations in OpenAlex.
- The ultrasonic vocalization (USV) syllable profile during neonatal opioid withdrawal and a kappa opioid receptor component to increased USV emissions in female mice.Psychopharmacology · 2025Article
- The ultrasonic vocalization (USV) syllable profile during neonatal opioid withdrawal and a kappa opioid receptor component to increased USV emissions in female mice.bioRxiv : the preprint server for biology · 2024Article
- Effect of prenatal and early post-natal oxycodone exposure on the reinforcing and antinociceptive effects of oxycodone in adult C57BL/6 J mice.Psychopharmacology · 2024Article
- Sex differences in neonatal outcomes following prenatal opioid exposure.Frontiers in pediatrics · 2024Review
- Article
- Review
- Neonatal opioid toxicity: opioid withdrawal (abstinence) syndrome with emphasis on pharmacogenomics and respiratory depression.Archives of toxicology · 2023Review
- Polygenic risk scores and the need for pharmacotherapy in neonatal abstinence syndrome.Pediatric research · 2023Article
- Placental microRNA methylome signatures may serve as biomarkers and therapeutic targets for prenatally opioid-exposed infants with neonatal opioid withdrawal syndrome.Frontiers in genetics · 2023Article
- A review of the genomics of neonatal abstinence syndrome.Frontiers in genetics · 2023Review
- Pharmacogenetics of Addiction Therapy.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Outcomes associated with the use of medications for opioid use disorder during pregnancy.Addiction (Abingdon, England) · 2021Article
- Integrated Review of the Assessment of Newborns With Neonatal Abstinence Syndrome.Journal of obstetric, gynecologic, and neonatal nursing : JOGNN · 2021Review
- Neuroimaging in infants with prenatal opioid exposure: Current evidence, recent developments and targets for future research.Journal of neuroradiology = Journal de neuroradiologie · 2021Review
- Neonatal Opioid Withdrawal Syndrome (NOWS): A Transgenerational Echo of the Opioid Crisis.Cold Spring Harbor perspectives in medicine · 2021Review
- PlacentalExploration of medicine · 2020Article
- Opioids affect the fetal brain: reframing the detoxification debate.American journal of obstetrics and gynecology · 2019Article
- Risk Factors Associated with the Occurrence of Neonatal Opioid Withdrawal Syndrome: A Review.CNS drugs · 2019Review
- Racial association and pharmacotherapy in neonatal opioid withdrawal syndrome.Journal of perinatology : official journal of the California Perinatal Association · 2019Observational
- Early life stress and environmental influences on the neurodevelopment of children with prenatal opioid exposure.Neurobiology of stress · 2018Review
Corrections and comments
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Authors and funding
7 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundThere is significant variability in the severity of neonatal abstinence syndrome (NAS) due to in-utero opioid exposure. We wanted to determine if single nucleotide polymorphisms (SNPs) in key candidate genes contribute to this variability.
methodsFull-term opioid-exposed newborns and their mothers (n=86 pairs) were studied. DNA was genotyped for 80 SNPs from 14 genes utilizing a custom designed microarray. The association of each SNP with NAS outcomes was evaluated.
resultsSNPs in two opioid receptor genes in the infants were associated with worse NAS severity: (1) The PNOC rs732636 A allele (OR=3.8, p=0.004) for treatment with 2 medications and a longer hospital stay (LOS) of 5.8 days (p=0.01), and (2) The OPRK1 rs702764 C allele (OR=4.1, p=0.003) for treatment with 2 medications. The OPRM1 rs1799971 G allele (β=-6.9 days, p=0.02) and COMT rs740603 A allele (β=-5.3 days, p=0.01) were associated with shorter LOS. The OPRD1 rs204076 A allele in the mothers was associated with a longer LOS by 6.6 days (p=0.008). Results were significant point-wise but did not meet the experiment-wide significance level.
conclusionsThese findings suggest that SNPs in opioid receptor and the PNOC genes are associated with NAS severity. However, further testing in a large sample is warranted. This has important implications for prenatal prediction and personalized treatment regimens for infants at highest risk for severe NAS.
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