Evidence map›Paper›PMID 26233409›Full record

ArticleThe Review of scientific instruments2015

Desktop aligner for fabrication of multilayer microfluidic devices.

Xiang Li, Zeta Tak For Yu, Dalton Geraldo, Shinuo Weng, Nitesh Alve, Wu Dun, Akshay Kini, Karan Patel, Roberto Shu, Feng Zhang and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Review of scientific instruments, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
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  6. Precision enhanced alignment bonding technique with sacrificial strategy.Frontiers in bioengineering and biotechnology · 2023
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  11. Review
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  18. A reproducible method forBiomicrofluidics · 2017
    Article
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  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Xiang LiDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Zeta Tak For YuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Dalton GeraldoDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Shinuo WengDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Nitesh AlveDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Wu DunDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Akshay KiniDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Karan PatelDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Roberto ShuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Feng ZhangDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Gang LiShanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Qinghui JinShanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China.
Jianping FuDepartment of Mechanical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
University of Michigan · USShanghai Institute of Microsystem and Information Technology · CN

Funding

Microfluidic Functional Immunophenotyping of Pediatric Patients Following CardiopR01HL119542 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CORNELL, TIMOTHY T, FU, JIANPING · 2014 to 2017
$2.7M
NHLBI NIH HHS R01 HL119542
6 · The paper itself

Abstract

Multilayer assembly is a commonly used technique to construct multilayer polydimethylsiloxane (PDMS)-based microfluidic devices with complex 3D architecture and connectivity for large-scale microfluidic integration. Accurate alignment of structure features on different PDMS layers before their permanent bonding is critical in determining the yield and quality of assembled multilayer microfluidic devices. Herein, we report a custom-built desktop aligner capable of both local and global alignments of PDMS layers covering a broad size range. Two digital microscopes were incorporated into the aligner design to allow accurate global alignment of PDMS structures up to 4 in. in diameter. Both local and global alignment accuracies of the desktop aligner were determined to be about 20 μm cm(-1). To demonstrate its utility for fabrication of integrated multilayer PDMS microfluidic devices, we applied the desktop aligner to achieve accurate alignment of different functional PDMS layers in multilayer microfluidics including an organs-on-chips device as well as a microfluidic device integrated with vertical passages connecting channels located in different PDMS layers. Owing to its convenient operation, high accuracy, low cost, light weight, and portability, the desktop aligner is useful for microfluidic researchers to achieve rapid and accurate alignment for generating multilayer PDMS microfluidic devices.

Indexed as

Lab-On-A-Chip DevicesDimethylpolysiloxanesEquipment DesignHumansLungMicrofluidicsMicroscopybaysilonDimethylpolysiloxanes

Identifiers

PMID26233409
PMCPMC4522017
OpenAlexW1594711334

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.