Evidence map›Paper›PMID 26233331›Full record

ArticleJournal of genetic counseling2016

Attitudes Toward Genetic Testing for Celiac Disease.

Abhik Roy, Michele Pallai, Benjamin Lebwohl, Annette K Taylor, Peter H Green

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of genetic counseling, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06179121 ("Adding DNA-test for Screening of HLA-DQ2 and DQ8 to Improve the Early Diagnosis of Celiac Disease at the Dutch Preventive Youth Healthcare Centres), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
1.2field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06179121 unknown statusnot on this mapstarted 2022, after this paper: background citation

"Adding DNA-test for Screening of HLA-DQ2 and DQ8 to Improve the Early Diagnosis of Celiac Disease at the Dutch Preventive Youth Healthcare Centres (GLUTEN-GEN)"

Typeobservational_patient_registrySponsorLeiden University Medical CenterRan2022 to 2024Enrolled508ConditionsCeliac Disease in ChildrenArmsDNA test for screening HLA-DQ2 and DQ8 from dried blood spots to early detect Celiac Disease
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Abhik RoyDepartment of Medicine, Celiac Disease Center, Columbia University Medical Center, Harkness Pavillion 180 Fort Washington Ave Room 936, New York, NY, 10032, USA.
Michele PallaiDepartment of Medicine, Celiac Disease Center, Columbia University Medical Center, Harkness Pavillion 180 Fort Washington Ave Room 936, New York, NY, 10032, USA.
Benjamin LebwohlDepartment of Medicine, Celiac Disease Center, Columbia University Medical Center, Harkness Pavillion 180 Fort Washington Ave Room 936, New York, NY, 10032, USA.
Annette K TaylorColorado Coagulation, Laboratory Corporation of America® Holdings, Englewood, CO, USA.
Peter H GreenDepartment of Medicine, Celiac Disease Center, Columbia University Medical Center, Harkness Pavillion 180 Fort Washington Ave Room 936, New York, NY, 10032, USA. pg11@cumc.columbia.edu.
Columbia University Irving Medical Center · USLeco Corporation (United States) · US

Funding

Multidisciplinary Training in Translational Gastrointestinal and Liver ResearchT32DK083256 · NIDDK · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Timothy Cragin Wang · 2009 to 2026
$5.5M
NIDDK NIH HHS T32 DK083256
6 · The paper itself

Abstract

HLA molecular typing for celiac disease (CD) is a genetic test with a high negative predictive value. The aim of this study is to explore knowledge of and attitudes towards genetic testing (GT). A 25-item questionnaire was developed by a multidisciplinary team and distributed to members of CD support groups across the United States. Respondents (n = 1835) were mainly female (88 %), married (76 %), and college-educated (55 %), with a median age range of 31-50 years. Those who were married (82 vs 75 %, p = 0.002), had children (82 vs 74 %, p < 0.001), and had pursued education beyond high school (81 vs 68 %, p = 0.004) were more likely to be aware of the availability of GT. On multivariable analysis, adjusting for age, sex, education, marital status, region of residence, and having children, college-education (OR 2.05, 95 % CI: 1.33-3.16) and having children (OR 1.56, 95 % CI: 1.15-2.11) remained significant predictors of GT awareness. A majority of patients with a personal or family history of CD planned GT for their children, and the most common concerns regarding GT were cost and impact on health care and/or insurance. In conclusion, awareness of GT is high among CD support group members. Efforts should be made to increase knowledge of GT in those with a lower educational level, and healthcare professionals should attempt to address concerns regarding GT cost and the impact of results on health care and insurance status.

Indexed as

Genetic TestingHealth Knowledge, Attitudes, PracticeAdultAwarenessCeliac DiseaseFemaleGenetic Predisposition to DiseaseHealth SurveysHistocompatibility TestingHumansMaleMiddle AgedSurveys and QuestionnairesUnited StatesAttitudesAwarenessCeliac diseaseEducationGeneticsGenetic testingHLAKnowledgeSupport groupsSurvey

Identifiers

PMID26233331
PMCPMC4993162
OpenAlexW997569777

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.