Evidence map›Paper›PMID 26233322›Full record

ArticleJournal of affective disorders2015

The variable heart: High frequency and very low frequency correlates of depressive symptoms in children and adolescents.

Julia D Blood, Jia Wu, Tara M Chaplin, Rebecca Hommer, Lauren Vazquez, Helena J V Rutherford, Linda C Mayes, Michael J Crowley

Abstract read
In one paragraph

Article in Journal of affective disorders, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
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  11. The Neurophysiology of the Cerebellum in Emotion.Advances in experimental medicine and biology · 2022
    Article
  12. Article
  13. Trends in Heart-Rate Variability Signal Analysis.Frontiers in digital health · 2021
    Review
  14. Article
  15. Observational
  16. Article
  17. Article
  18. Article
  19. Inflexibility as a Vulnerability to Depression: A Systematic Qualitative Review.Clinical psychology : a publication of the Division of Clinical Psychology of the American Psychological Association · 2017
    Article
  20. Consensus Paper: Cerebellum and Emotion.Cerebellum (London, England) · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Julia D BloodSchool of Medicine, University of Texas Health Science Center, San Antonio, TX, USA.
Jia WuYale Child Study Center, Yale School of Medicine, New Haven, CT, USA; Developmental Electrophysiology Laboratory, Yale Child Study Center, New Haven, CT, USA.
Tara M ChaplinDepartment of Psychology, George Mason University, Fairfax, VA, USA.
Rebecca HommerEmotion and Development Branch, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Lauren VazquezYale Child Study Center, Yale School of Medicine, New Haven, CT, USA.
Helena J V RutherfordYale Child Study Center, Yale School of Medicine, New Haven, CT, USA; Developmental Electrophysiology Laboratory, Yale Child Study Center, New Haven, CT, USA.
Linda C MayesYale Child Study Center, Yale School of Medicine, New Haven, CT, USA; Developmental Electrophysiology Laboratory, Yale Child Study Center, New Haven, CT, USA.
Michael J CrowleyYale Child Study Center, Yale School of Medicine, New Haven, CT, USA; Program for Anxiety Disorders, Yale Child Study Center, New Haven, CT, USA; Developmental Electrophysiology Laboratory, Yale Child Study Center, New Haven, CT, USA; Center for Translational Developmental Neuroscience, Yale Child Study Center, New Haven, CT, USA. Electronic address: michael.crowley@yale.edu.

Funding

YALE UNIVERSITY CLINICAL AND TRANSLATIONAL SCIENCE AWARD PROGRAMUL1RR024139 · NCRR · YALE UNIVERSITY · PI SHERWIN, ROBERT S · 2006 to 2011
$56.8M
REGULATION OF AROUSAL AND ATTENTION IN COCAINE EXPOSEDR01DA006025 · NIDA · YALE UNIVERSITY · PI MAYES, LINDA CAROL · 1992 to 2007
$6.0M
Research Training for Medical Students & Physician-Scientists in Child PsychiatryR25MH077823 · NIMH · YALE UNIVERSITY · PI ANDRES S MARTIN · 2006 to 2026
$4.0M
Cocaine-Exposed Children & Event Related Potential Studies of NeurocognitionR01DA017863 · NIDA · YALE UNIVERSITY · PI MAYES, LINDA CAROL · 2004 to 2008
$1.7M
Interdisciplinary Research on Stress, Self-Control & AddictionUL1RR024925 · NCRR · YALE UNIVERSITY · PI SINHA, RAJITA · 2007 to 2007
$849k
Neural Correlates of Negative Reinforcement in Adolescence & Substance Use RiskK01DA034125 · NIDA · YALE UNIVERSITY · PI CROWLEY, MICHAEL J · 2012 to 2016
$823k
NCRR NIH HHS 1UL1RR024925-01NCRR NIH HHS UL1 RR024139NCRR NIH HHS UL1RR024139NCRR NIH HHS UL1 RR024925NIDA NIH HHS DA-017863NIDA NIH HHS K01 DA034125NIDA NIH HHS K01DA034125NIDA NIH HHS R01 DA006025NIDA NIH HHS R01 DA017863NIDA NIH HHS R01-DA-06025NIMH NIH HHS R25 MH077823
6 · The paper itself

Abstract

backgroundWork examining the link between lower heart rate variability (HRV) and depression in children and adolescents is lacking, especially in light of the physiological changes that occur during pubertal development.

methodWe investigated the association between spectral measures of resting HRV and depressive symptoms among 127 children and adolescents, ages 10-17. Using spectral analysis, we evaluated (1) the association between relative high frequency (HF) HRV and depressive symptoms; (2) the predictive power of relative HF HRV for depressive symptoms in the context of relative low frequency (LF) and relative very low frequency (VLF) HRV; and (3) the relationship between relative HF, LF, and VLF band activity, age and pubertal maturation.

resultsConsistent with previous work, results revealed that relative HF HRV was negatively associated with self-reported depressive symptoms. As well, relative VLF HRV was positively associated with depressive symptoms. Regression analyses revealed that relative HF HRV and relative VLF HRV significantly predicted self-report depressive symptoms while controlling for age, sex and pubertal maturation, with relative VLF HRV emerging as the strongest indicator of depressive symptoms. Developmental findings also emerged. Age and pubertal maturation were negatively associated with relative HF HRV and positively correlated with relative VLF HRV.

conclusionsResults provide support for the relationship between HRV and depression and suggest that both HF and VLF HRV are relevant to depression symptom severity. Findings also reinforce the importance of considering pubertal development when investigating HRV-depression associations in children and adolescents. LIMITATIONS: Influences on cardiac control including physical activity levels and exercise patterns could be controlled in future work. Our data speak to a depressive symptom dimension and relative spectral power HRV. Thus, we cannot make strong claims about relative spectral power HRV and clinical depression.

Indexed as

AdolescentAgingChildDepressionFemaleHeart RateHumansMalePubertyRegression AnalysisAdolescencedepressionheart rate variabilitytime-frequency analysis

Identifiers

PMID26233322
PMCPMC4565756

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.