Evidence map›Paper›PMID 26232927›Full record

ArticleIrish journal of medical science2016

Effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome.

S Uslu, E Ozcelik, N Kebapci, H E Temel, F Demirci, B Ergun, C Demirustu

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Article in Irish journal of medical science, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

S UsluDepartment of Biochemistry, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
E OzcelikDepartment of Nutrition and Dietetics, School of Healthy, Artvin Coruh University, Artvin, Turkey. eda_ozcelik@artvin.edu.tr.
N KebapciDepartment of Endocrinology, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
H E TemelDepartment of Biochemistry, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
F DemirciDepartment of Pharmacognosy, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
B ErgunDepartment of Toxicology, Faculty of Pharmacy, Anadolu University, Eskisehir, Turkey.
C DemirustuDepartment of Biostatistics, Medical Faculty, Eskisehir Osmangazi University, Eskisehir, Turkey.
Eskişehir Osmangazi University · TRAnadolu University · TRArtvin Coruh University · TREskişehir City Hospital · TR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundElevated serum uric acid levels and increased arginase activity are risk factors for cardiovascular diseases (CVD). The aim of the present study was to investigate effects of serum uric acid levels on the arginase pathway in women with metabolic syndrome (MetS).

methodsSerum arginase activity, and nitrite and uric acid levels were measured in 48 women with MetS and in 20 healthy controls. The correlation of these parameters with components of MetS was also evaluated.

resultsOur data show statistically higher arginase activity and uric acid levels but lower nitrite levels in women with MetS compared to controls. Serum uric acid levels were negatively correlated with HDL cholesterol, nitrite levels and positively with Body Mass Index, waist to hip ratio, triglyceride and total cholesterol levels, systolic blood pressure, Homeostasis Model Assessment-Insulin Resistance-Index, serum arginase activity, and LDL-cholesterol levels in women with MetS.

conclusionResults of the present study suggest that serum uric acid levels may contribute to the pathogenesis of MetS through a process mediated by arginase pathway, and serum arginase activity and nitrite and uric acid levels can be used as indicators of CVD in women with MetS.

Indexed as

AdultArginaseBlood GlucoseBody Mass IndexCardiovascular DiseasesCase-Control StudiesCholesterol, HDLFemaleHumansInsulin ResistanceMetabolic SyndromeMiddle AgedRisk FactorsTriglyceridesUric AcidArginaseBlood GlucoseCholesterol, HDLTriglyceridesUric AcidArginase pathwayMetabolic syndromeSerum uric acid levels

Identifiers

PMID26232927
OpenAlexW950028071

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.