Evidence map›Paper›PMID 26232913›Full record

ReviewTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015

Endothelial progenitor cells support tumour growth and metastatisation: implications for the resistance to anti-angiogenic therapy.

Francesco Moccia, Estella Zuccolo, Valentina Poletto, Mariapia Cinelli, Elisa Bonetti, Germano Guerra, Vittorio Rosti

Abstract readReview
PubMed Publisher
In one paragraph

Review in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Review
  6. Role of Endothelial Progenitor Cells in Frailty.International journal of molecular sciences · 2023
    Review
  7. Review
  8. Transient Receptor Potential (TRP) Channels in Tumor Vascularization.International journal of molecular sciences · 2022
    Review
  9. Review
  10. Multifunctional Heterometallic IrChemistry (Weinheim an der Bergstrasse, Germany) · 2021
    Article
  11. Article
  12. Review
  13. Tumor angiogenesis: causes, consequences, challenges and opportunities.Cellular and molecular life sciences : CMLS · 2020
    Review
  14. Endothelial CaInternational journal of molecular sciences · 2019
    Review
  15. Review
  16. Article
  17. Endolysosomal CaCancers · 2018
    Review
  18. Article
  19. Endothelial CaInternational journal of molecular sciences · 2018
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 1 country.

Francesco MocciaLaboratory of General Physiology, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, via Forlanini 6, 27100, Pavia, Italy. francesco.moccia@unipv.it.
Estella ZuccoloLaboratory of General Physiology, Department of Biology and Biotechnology "L. Spallanzani", University of Pavia, via Forlanini 6, 27100, Pavia, Italy.
Valentina PolettoUnit of Clinical Epidemiology, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.
Mariapia CinelliDepartment of Public Health, University of Naples "Federico II", via Pansini 5, 80131, Naples, Italy.
Elisa BonettiUnit of Clinical Epidemiology, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.
Germano GuerraDepartment of Medicine and Health Sciences "V. Tiberio", University of Molise, Via F. De Santis, 86100, Campobasso, Italy.
Vittorio RostiUnit of Clinical Epidemiology, Fondazione IRCCS Policlinico San Matteo, 27100, Pavia, Italy.
Policlinico San Matteo Fondazione · ITUniversity of Pavia · ITUniversity of Molise · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endothelial progenitor cells (EPCs) have recently been shown to promote the angiogenic switch in solid neoplasms, thereby promoting tumour growth and metastatisation. The genetic suppression of EPC mobilization from bone marrow prevents tumour development and colonization of remote organs. Therefore, it has been assumed that anti-angiogenic treatments, which target vascular endothelial growth factor (VEGF) signalling in both normal endothelial cells and EPCs, could interfere with EPC activation in cancer patients. Our recent data, however, show that VEGF fails to stimulate tumour endothelial colony-forming cells (ECFCs), i.e. the only EPC subtype truly belonging to the endothelial lineage. The present article will survey current evidence about EPC involvement in the angiogenic switch: we will focus on the controversy about EPC definition and on the debate around their actual incorporation into tumour neovessels. We will then discuss how ECFC insensitivity to VEGF stimulation in cancer patients could underpin their well-known resistance to anti-VEGF therapies.

Indexed as

CalciumDrug Resistance, NeoplasmEndothelial Progenitor CellsGene Expression Regulation, NeoplasticHumansNeoplasmsNeovascularization, PathologicSignal TransductionVascular Endothelial Growth Factor ACalciumVascular Endothelial Growth Factor AVEGFA protein, humanAnti-angiogenic therapyCa2+ signallingEndothelial progenitor cellsPatient refractorinessRenal cellular carcinomaTumour vascularisationVascular endothelial growth factor

Identifiers

PMID26232913
OpenAlexW2158794173

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.