ArticleJournal of the American Society of Echocardiography : official publication of the American Society of Echocardiography2015
Role of Diastolic Function in Preserved Exercise Capacity in Patients with Reduced Ejection Fractions.
Article in Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.
- Effect of exercise on diastolic function in heart failure patients: a systematic review and meta-analysis.Heart failure reviews · 2017Pooled it
- Article
- Left atrial strain predicts exercise capacity in heart failure independently of left ventricular ejection fraction.ESC heart failure · 2022Article
- Right ventricular function and its coupling to pulmonary circulation predicts exercise tolerance in systolic heart failure.ESC heart failure · 2022Article
- Diabetes Is the Strongest Predictor of Limited Exercise Capacity in Chronic Heart Failure and Preserved Ejection Fraction (HFpEF).Frontiers in cardiovascular medicine · 2022Article
- Left ventricular function in patients with hypertrophic cardiomyopathy and its relation to myocardial fibrosis and exercise tolerance.The international journal of cardiovascular imaging · 2018Article
- Different determinants of exercise capacity in HFpEF compared to HFrEF.Cardiovascular ultrasound · 2017Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundSome patients with markedly reduced ejection fractions (EFs) (<35%) have preserved exercise performance greater than predicted for age and gender. Because diastolic function may be a determinant of exercise performance, this study was conducted to test the hypothesis that patients with preserved exercise tolerance despite EFs < 35% may have relatively normal diastolic function.
methodsSixty-five subjects with EFs < 35% who underwent exercise Doppler echocardiography and had no inducible ischemia were retrospectively examined. Forty-five subjects with normal EFs (>60%) and preserved exercise capacity were analyzed as a control group.
resultsSixteen of 65 patients with EFs < 35% had greater than predicted normal exercise capacity for their age and gender, and the remaining 49 patients had reduced exercise capacity. Patients with reduced EFs and preserved exercise capacity had E/e' ratios (mean, 10 ± 4) similar to those of control subjects (mean, 10 ± 3) and lower than those with reduced exercise tolerance (mean, 16 ± 8) (P < .01). In addition, they had better diastolic filling patterns and smaller left atrial sizes than patients with EFs < 35% and reduced exercise capacity. Multivariate logistic regression analyses indicated that E/e' ratio was an independent predictor of preserved exercise capacity in patients with reduced EFs.
conclusionsRelatively intact diastolic function contributes to preserved exercise capacity in patients with reduced EFs (<35%).
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Registered trials
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