ArticleClinical immunology (Orlando, Fla.)2015
Developmentally determined reduction in CD31 during gestation is associated with CD8+ T cell effector differentiation in preterm infants.
Article in Clinical immunology (Orlando, Fla.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01607216 (Prematurity and Respiratory Outcome Program), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prematurity and Respiratory Outcome Program: Single Center Study of Functional and Lymphocytic Markers of Respiratory Morbidity in Hyperoxic Preemies
Who cites it
21 citing papers in PubMed, 27 citations in OpenAlex.
- Extremely Preterm Infants Have Significant Alterations in Their Conventional T Cell Compartment during the First Weeks of Life.Journal of immunology (Baltimore, Md. : 1950) · 2020Trial
- The immune system of preterm infants: an overview.Frontiers in immunology · 2026Review
- Lifelong partners: Gut microbiota-immune cell interactions from infancy to old age.Mucosal immunology · 2025Review
- Transfusion of Adult, but Not Neonatal, Platelets Promotes Monocyte Trafficking in Neonatal Mice.Arteriosclerosis, thrombosis, and vascular biology · 2023Article
- Immunity to Influenza Infection in Humans.Cold Spring Harbor perspectives in medicine · 2021Review
- Immune Response of Indian Preterm Infants to Pentavalent Vaccine Varies With Component Antigens and Gestational Age.Frontiers in immunology · 2021Article
- Impact and Clinical Implications of Prematurity on Adaptive Immune Development.Current pediatrics reports · 2020Article
- Phenotypes of Bronchopulmonary Dysplasia.International journal of molecular sciences · 2020Review
- Eight practices for data management to enable team data science.Journal of clinical and translational science · 2020Article
- The development of pain circuits and unique effects of neonatal injury.Journal of neural transmission (Vienna, Austria : 1996) · 2020Review
- T Cells in Preterm Infants and the Influence of Milk Diet.Frontiers in immunology · 2020Review
- Dissecting the defects in the neonatal CD8Journal of leukocyte biology · 2019Review
- Endothelial cell-specific anticoagulation reduces inflammation in a mouse model of acute lung injury.Acta pharmacologica Sinica · 2019Article
- Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8Journal of leukocyte biology · 2018Article
- T cell developmental arrest in former premature infants increases risk of respiratory morbidity later in infancy.JCI insight · 2018Article
- Immunomodulation to Prevent or Treat Neonatal Sepsis: Past, Present, and Future.Frontiers in pediatrics · 2018Review
- Characterization of CD31 expression on murine and human neonatal T lymphocytes during development and activation.Pediatric research · 2017Article
- Lifetime Modulation of the Pain SystemFrontiers in immunology · 2017Review
- Preterm infants have significantly longer telomeres than their term born counterparts.PloS one · 2017Observational
- Flow-based sorting of neonatal lymphocyte populations for transcriptomics analysis.Journal of immunological methods · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Homeostatic T cell proliferation is more robust during human fetal development. In order to understand the relative effect of normal fetal homeostasis and perinatal exposures on CD8+ T cell behavior in PT infants, we characterized umbilical cord blood CD8+ T cells from infants born between 23-42weeks gestation. Subjects were recruited as part of the NHLBI-sponsored Prematurity and Respiratory Outcomes Program. Cord blood from PT infants had fewer naïve CD8+ T cells and lower regulatory CD31 expression on both naïve and effector, independent of prenatal exposures. CD8+ T cell in vitro effector function was greater at younger gestational ages, an effect that was exaggerated in infants with prior inflammatory exposures. These results suggest that CD8+ T cells earlier in gestation have loss of regulatory co-receptor CD31 and greater effector differentiation, which may place PT neonates at unique risk for CD8+ T cell-mediated inflammation and impaired T cell memory formation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.