ArticlePlant physiology2015
Bypassing Iron Storage in Endodermal Vacuoles Rescues the Iron Mobilization Defect in the natural resistance associated-macrophage protein3natural resistance associated-macrophage protein4 Double Mutant.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Meta-QTL analysis of seed iron and zinc concentration and content in common bean (Phaseolus vulgaris L.).TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2018Pooled it
- FePlant, cell & environment · 2026Article
- Elucidation of the genetic basis underlying rooting ability in vegetatively propagated chrysanthemum.Horticulture research · 2026Article
- Genome-Wide Identification of Natural Resistance-Associated Macrophage Protein (NRAMP) and Expression Analysis Under Heavy Metal Stress inPlants (Basel, Switzerland) · 2025Article
- GmFER1, a soybean ferritin, enhances tolerance to salt stress and root rot disease and improves soybean yield.Plant biotechnology journal · 2025Article
- Arabidopsis MEB3 functions as a vacuolar metal transporter to regulate iron accumulation in roots.Frontiers in plant science · 2025Article
- Article
- Systematic Analysis of NRAMP Family Genes inInternational journal of molecular sciences · 2023Article
- Biofortification of common bean (Food and energy security · 2023Review
- B3 Transcription Factors Determine Iron Distribution andFrontiers in plant science · 2022Article
- Genome-Wide Identification and Expression Analysis of thePlants (Basel, Switzerland) · 2021Article
- A Golgi-localized manganese transporter functions in pollen tube tip growth to control male fertility inPlant communications · 2021Article
- Importance of the Rhizosphere Microbiota in Iron Biofortification of Plants.Frontiers in plant science · 2021Review
- Review
- Structure and function of the vacuolar Ccc1/VIT1 family of iron transporters and its regulation in fungi.Computational and structural biotechnology journal · 2020Review
- How Plants Handle Trivalent (+3) Elements.International journal of molecular sciences · 2019Review
- Copper transporter COPT5 participates in the crosstalk between vacuolar copper and iron pools mobilisation.Scientific reports · 2019Article
- Autophagy is essential for optimal translocation of iron to seeds in Arabidopsis.Journal of experimental botany · 2019Article
- Comparative transcriptome analysis reveals gene network regulating cadmium uptake and translocation in peanut roots under iron deficiency.BMC plant biology · 2019Article
- The Intracellular Transporter AtNRAMP6 Is Involved in Fe Homeostasis inFrontiers in plant science · 2019Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 2 countries.
Funding
Abstract
To improve seed iron (Fe) content and bioavailability, it is crucial to decipher the mechanisms that control Fe storage during seed development. In Arabidopsis (Arabidopsis thaliana) seeds, most Fe is concentrated in insoluble precipitates, with phytate in the vacuoles of cells surrounding the vasculature of the embryo. NATURAL RESISTANCE ASSOCIATED-MACROPHAGE PROTEIN3 (AtNRAMP3) and AtNRAMP4 function redundantly in Fe retrieval from vacuoles during germination. When germinated under Fe-deficient conditions, development of the nramp3nramp4 double mutant is arrested as a consequence of impaired Fe mobilization. To identify novel genes involved in seed Fe homeostasis, we screened an ethyl methanesulfonate-mutagenized population of nramp3nramp4 seedlings for mutations suppressing their phenotypes on low Fe. Here, we report that, among the suppressors, two independent mutations in the VACUOLAR IRON TRANSPORTER1 (AtVIT1) gene caused the suppressor phenotype. The AtVIT1 transporter is involved in Fe influx into vacuoles of endodermal and bundle sheath cells. This result establishes a functional link between Fe loading in vacuoles by AtVIT1 and its remobilization by AtNRAMP3 and AtNRAMP4. Moreover, analysis of subcellular Fe localization indicates that simultaneous disruption of AtVIT1, AtNRAMP3, and AtNRAMP4 limits Fe accumulation in vacuolar globoids.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.