ArticleGenome research2015
Comparison against 186 canid whole-genome sequences reveals survival strategies of an ancient clonally transmissible canine tumor.
Article in Genome research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
43 citing papers in PubMed, 72 citations in OpenAlex.
- Comparative Genetics of Canine and Human Cancers.Veterinary sciences · 2025Review
- Late Pleistocene onset of mutualistic human/canid (Science advances · 2024Article
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- Centuries of genome instability and evolution in soft-shell clam, Mya arenaria, bivalve transmissible neoplasia.Nature cancer · 2023Article
- The extinct Sicilian wolf shows a complex history of isolation and admixture with ancient dogs.iScience · 2023Article
- Conservation implications of elucidating the Korean wolf taxonomic ambiguity through whole-genome sequencing.Ecology and evolution · 2023Article
- Compensatory phenolic induction dynamics in aspen after aphid infestation.Scientific reports · 2022Article
- Characterizing the molecular and immune landscape of canine bladder cancer.Veterinary and comparative oncology · 2022Article
- Across-breed genetic investigation of canine hip dysplasia, elbow dysplasia, and anterior cruciate ligament rupture using whole-genome sequencing.Frontiers in genetics · 2022Article
- Small extracellular vesicle DNA-mediated horizontal gene transfer as a driving force for tumor evolution: Facts and riddles.Frontiers in oncology · 2022Review
- Genomics and transcriptomics in veterinary oncology.Oncology letters · 2021Review
- Roan, ticked and clear coat patterns in the canine are associated with three haplotypes near usherin on CFA38.Animal genetics · 2021Article
- Genomes of Pleistocene Siberian Wolves Uncover Multiple Extinct Wolf Lineages.Current biology : CB · 2021Article
- New Guinea highland wild dogs are the original New Guinea singing dogs.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Transmissible Cancers in an Evolutionary Perspective.iScience · 2020Review
- MultipleGenes · 2020Article
- Arctic-adapted dogs emerged at the Pleistocene-Holocene transition.Science (New York, N.Y.) · 2020Article
- How Safe Are Universal Pluripotent Stem Cells?Cell stem cell · 2020Article
- The evolution of resistance and tolerance as cancer defences.Parasitology · 2020Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 3 countries.
Funding
Abstract
Canine transmissible venereal tumor (CTVT) is a parasitic cancer clone that has propagated for thousands of years via sexual transfer of malignant cells. Little is understood about the mechanisms that converted an ancient tumor into the world's oldest known continuously propagating somatic cell lineage. We created the largest existing catalog of canine genome-wide variation and compared it against two CTVT genome sequences, thereby separating alleles derived from the founder's genome from somatic mutations that must drive clonal transmissibility. We show that CTVT has undergone continuous adaptation to its transmissible allograft niche, with overlapping mutations at every step of immunosurveillance, particularly self-antigen presentation and apoptosis. We also identified chronologically early somatic mutations in oncogenesis- and immune-related genes that may represent key initiators of clonal transmissibility. Thus, we provide the first insights into the specific genomic aberrations that underlie CTVT's dogged perseverance in canids around the world.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.