ArticleGenetics2015
Regulatory Rewiring in a Cross Causes Extensive Genetic Heterogeneity.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Gain- and loss-of-function alleles within signaling pathways lead to phenotypic diversity among individuals.iScience · 2024Article
- System drift and speciation.Evolution; international journal of organic evolution · 2022Article
- Gene by Environment Interactions reveal new regulatory aspects of signaling network plasticity.PLoS genetics · 2022Article
- The complex role of genetic background in shaping the effects of spontaneous and induced mutations.Yeast (Chichester, England) · 2021Review
- Variation in Filamentous Growth and Response to Quorum-Sensing Compounds in Environmental Isolates ofG3 (Bethesda, Md.) · 2019Article
- Article
- The rewiring of transcription circuits in evolution.Current opinion in genetics & development · 2017Review
- Genetic suppression: Extending our knowledge from lab experiments to natural populations.BioEssays : news and reviews in molecular, cellular and developmental biology · 2017Review
- Epistasis: Searching for Interacting Genetic Variants Using Crosses.G3 (Bethesda, Md.) · 2017Article
- Review
- Gene-Environment Interactions in Stress Response Contribute Additively to a Genotype-Environment Interaction.PLoS genetics · 2016Article
- Diverse genetic architectures lead to the same cryptic phenotype in a yeast cross.Nature communications · 2016Article
- Genetic assimilation: a review of its potential proximate causes and evolutionary consequences.Annals of botany · 2016Review
- Multi-locus Genotypes Underlying Temperature Sensitivity in a Mutationally Induced Trait.PLoS genetics · 2016Article
- The complex genetic and molecular basis of a model quantitative trait.Molecular biology of the cell · 2016Article
- Transcriptional Derepression Uncovers Cryptic Higher-Order Genetic Interactions.PLoS genetics · 2015Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Genetic heterogeneity occurs when individuals express similar phenotypes as a result of different underlying mechanisms. Although such heterogeneity is known to be a potential source of unexplained heritability in genetic mapping studies, its prevalence and molecular basis are not fully understood. Here we show that substantial genetic heterogeneity underlies a model phenotype--the ability to grow invasively--in a cross of two Saccharomyces cerevisiae strains. The heterogeneous basis of this trait across genotypes and environments makes it difficult to detect causal loci with standard genetic mapping techniques. However, using selective genotyping in the original cross, as well as in targeted backcrosses, we detected four loci that contribute to differences in the ability to grow invasively. Identification of causal genes at these loci suggests that they act by changing the underlying regulatory architecture of invasion. We verified this point by deleting many of the known transcriptional activators of invasion, as well as the gene encoding the cell surface protein Flo11 from five relevant segregants and showing that these individuals differ in the genes they require for invasion. Our work illustrates the extensive genetic heterogeneity that can underlie a trait and suggests that regulatory rewiring is a basic mechanism that gives rise to this heterogeneity.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.