ArticleJournal of dental research2015
Store-operated Ca2+ Entry Modulates the Expression of Enamel Genes.
Article in Journal of dental research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Developing Optogenetic Approaches to Study CaCold Spring Harbor perspectives in biology · 2026Review
- Functional model for amelogenesis: polarization and pH sensitivity of calcium uptake in ameloblast-derived HAT-7 cells.Calcified tissue international · 2026Article
- Mathematical Modeling of Calcium Dynamics in Ameloblasts.Calcified tissue international · 2026Article
- Mechanosensitive Piezo1 Channels in Enamel Cells.Calcified tissue international · 2026Article
- Na+/Ca2+ exchange in enamel cells is dominated by the K+-dependent NCKX exchanger.The Journal of general physiology · 2024Article
- Deciphering the functions of Stromal Interaction Molecule-1 in amelogenesis using AmelX-iCre mice.Frontiers in physiology · 2023Article
- Overexpression ofCells · 2022Article
- Mitochondria modulate ameloblast CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2022Article
- Fluoride exposure alters CaScience signaling · 2020Article
- Mitochondrial Function in Enamel Development.Frontiers in physiology · 2020Article
- Calcium Sets the Clock in Ameloblasts.Frontiers in physiology · 2020Article
- The roles of Orai and Stim in bone health and disease.Cell calcium · 2019Review
- Differential regulation of CaScience signaling · 2019Article
- CRAC channels in dental enamel cells.Cell calcium · 2018Review
- Evidence That Calcium Entry Into Calcium-Transporting Dental Enamel Cells Is Regulated by Cholecystokinin, Acetylcholine and ATP.Frontiers in physiology · 2018Article
- High pH-Sensitive Store-Operated CaFrontiers in physiology · 2018Article
- DENTAL ENAMEL FORMATION AND IMPLICATIONS FOR ORAL HEALTH AND DISEASE.Physiological reviews · 2017Review
- Enamel: Molecular identity of its transepithelial ion transport system.Cell calcium · 2017Review
- CaThe Journal of physiology · 2017Review
- Store-operated CaJCI insight · 2017Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
Dental enamel formation is an intricate process tightly regulated by ameloblast cells. The correct spatiotemporal patterning of enamel matrix protein (EMP) expression is fundamental to orchestrate the formation of enamel crystals, which depend on a robust supply of Ca2+. In the extracellular milieu, Ca2+ -EMP interactions occur at different levels. Despite its recognized role in enamel development, the molecular machinery involved in Ca2+ homeostasis in ameloblasts remains poorly understood. A common mechanism for Ca2+ influx is store-operated Ca2+ entry (SOCE). We evaluated the possibility that Ca2+ influx in enamel cells might be mediated by SOCE and the Ca2+ release-activated Ca2+ (CRAC) channel, the prototypical SOCE channel. Using ameloblast-like LS8 cells, we demonstrate that these cells express Ca2+ -handling molecules and mediate Ca2+ influx through SOCE. As a rise in the cytosolic Ca2+ concentration is a versatile signal that can modulate gene expression, we assessed whether SOCE in enamel cells had any effect on the expression of EMPs. Our results demonstrate that stimulating LS8 cells or murine primary enamel organ cells with thapsigargin to activate SOCE leads to increased expression of Amelx, Ambn, Enam, Mmp20. This effect is reversed when cells are treated with a CRAC channel inhibitor. These data indicate that Ca2+ influx in LS8 cells and enamel organ cells is mediated by CRAC channels and that Ca2+ signals enhance the expression of EMPs. Ca2+ plays an important role not only in mineralizing dental enamel but also in regulating the expression of EMPs.
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