ReviewAmerican journal of physiology. Heart and circulatory physiology2015
Translational approaches to understanding metabolic dysfunction and cardiovascular consequences of obstructive sleep apnea.
Review in American journal of physiology. Heart and circulatory physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
58 citing papers in PubMed, 116 citations in OpenAlex.
- Optimal Continuous Positive Airway Pressure Treatment of Obstructive Sleep Apnea Reduces Daytime Resting Heart Rate in Prediabetes: A Randomized Controlled Study.Journal of the American Heart Association · 2020Trial
- Awake Multimodal Phenotyping for Prediction of Oral Appliance Treatment Outcome.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Trial
- Sleep-disordered breathing, circulating exosomes, and insulin sensitivity in adipocytes.International journal of obesity (2005) · 2018Trial
- Sleep, Neural Circulatory Control, and Cardiovascular Disease: A Mechanistic Review.Arteriosclerosis, thrombosis, and vascular biology · 2026Review
- Poor sleep impairs immune responses and influenza vaccine protection.Nature communications · 2026Article
- The independent predictive effect of insomnia symptoms before high-altitude exposure on acute mountain sickness: an observational study of healthy volunteers at 2726 m.Frontiers in psychiatry · 2026Article
- Obstructive sleep apnea and outcomes in acute pulmonary embolism: A large-scale database study.PloS one · 2026Article
- Assessing cognitive impairment in OSAHS patients through NODDI-based gray matter analysis.BMC neurology · 2025Article
- Narrative review of metabolic syndrome and its relationships with non-alcoholic fatty liver disease, gonadal dysfunction and obstructive sleep apnea.Diabetology & metabolic syndrome · 2025Review
- Evaluation of sleep position shifts in patients with obstructive sleep apnea syndrome with the use of a mandibular advancement device.Frontiers in dental medicine · 2025Article
- Associations of Sleep-Disordered Breathing and Insomnia with Incident Metabolic Syndrome - The Hispanic Community Health Study/Study of Latinos.Nature and science of sleep · 2025Article
- Obstructive sleep apnea and hypertension; critical overview.Clinical hypertension · 2024Review
- Links Between Obstructive Sleep Apnea and Myocardial Blood Flow Changes Impacting Adverse Cardiovascular Disease-related Outcomes.Current cardiology reports · 2024Review
- Association of obstructive sleep apnea symptoms with all-cause mortality and cause-specific mortality in adults with or without diabetes: A cohort study based on the NHANES.Journal of diabetes · 2024Article
- The potential of clinical prediction model development from a change in cardiac repolarization and pulse oximetry data in patients with undiagnosed obstructive sleep apnea undergoing coronary artery bypass grafting.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Article
- Symptom and comorbidity burden in hypertensive patients with obstructive sleep apnea.Frontiers in endocrinology · 2024Article
- Chronic intermittent hypoxia aggravated diabetic cardiomyopathy through LKB1/AMPK/Nrf2 signaling pathway.PloS one · 2024Article
- Hyperfructosemia in sleep disordered breathing: metabolome analysis of Nagahama study.Scientific reports · 2023Article
- International Consensus Statement on Obstructive Sleep Apnea.International forum of allergy & rhinology · 2023Review
- Investigating the Relationship between Obstructive Sleep Apnoea, Inflammation and Cardio-Metabolic Diseases.International journal of molecular sciences · 2023Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Obstructive sleep apnea (OSA) is known to be independently associated with several cardiovascular diseases including hypertension, myocardial infarction, and stroke. To determine how OSA can increase cardiovascular risk, animal models have been developed to explore the underlying mechanisms and the cellular and end-organ targets of the predominant pathophysiological disturbance in OSA-intermittent hypoxia. Despite several limitations in translating data from animal models to the clinical arena, significant progress has been made in our understanding of how OSA confers increased cardiovascular risk. It is clear now that the hypoxic stress associated with OSA can elicit a broad spectrum of pathological systemic events including sympathetic activation, systemic inflammation, impaired glucose and lipid metabolism, and endothelial dysfunction, among others. This review provides an update of the basic, clinical, and translational advances in our understanding of the metabolic dysfunction and cardiovascular consequences of OSA and highlights the most recent findings and perspectives in the field.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.