ArticleRadiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology2015
Proton versus conventional radiotherapy for pediatric salivary gland tumors: Acute toxicity and dosimetric characteristics.
Article in Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Evidence-based indications for proton therapy in adults determined using the GRADE approach.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Pooled it
- Clinicopathologic features and integrated outcome analysis of pediatric and young adult salivary secretory carcinoma.Frontiers in oncology · 2026Article
- Clinical outcomes of particle beam radiation therapy for patients with newly-diagnosed major salivary gland tumors.BMC cancer · 2025Article
- Dosimetric and NTCP analyses for selecting parotid gland cancer patients for proton therapy.Tumori · 2024Article
- Clinical outcome after pencil beam scanning proton therapy and dysphagia/xerostomia NTCP calculations of proton and photon radiotherapy delivered to patients with cancer of the major salivary glands.The British journal of radiology · 2023Article
- Exploring the Epidemiology and Survival Trends in Pediatric Major Salivary Gland Malignancies: Insights from the National Cancer Database.Current oncology (Toronto, Ont.) · 2023Article
- Surgical management of pediatric salivary malignant tumors-A single-center cohort study.Journal of surgical oncology · 2022Article
- Intensity-modulated proton and carbon-ion radiation therapy in the management of major salivary gland carcinomas.Annals of translational medicine · 2022Article
- Comparison of the efficacy and toxicity of postoperative proton versus carbon ion radiotherapy for head and neck cancers.Annals of translational medicine · 2022Article
- Proton Therapy for Major Salivary Gland Cancer: Clinical Outcomes.International journal of particle therapy · 2021Article
- Proton Radiotherapy to Reduce Late Complications in Childhood Head and Neck Cancers.International journal of particle therapy · 2021Article
- Clinical Review of Proton Therapy in the Treatment of Unilateral Head and Neck Cancers.International journal of particle therapy · 2021Article
- Proton-irradiated breast cells: molecular points of view.Journal of radiation research · 2019Article
- Gene expression profiling of breast cancer cell lines treated with proton and electron radiations.The British journal of radiology · 2018Article
- National Cancer Institute Workshop on Proton Therapy for Children: Considerations Regarding Brainstem Injury.International journal of radiation oncology, biology, physics · 2018Review
- Prognostic impact of leukocyte counts before and during radiotherapy for oropharyngeal cancer.Clinical and translational radiation oncology · 2017Article
- Intensity-modulated proton therapy and osteoradionecrosis in oropharyngeal cancer.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2017Article
- Intensity-modulated proton beam therapy (IMPT) versus intensity-modulated photon therapy (IMRT) for patients with oropharynx cancer - A case matched analysis.Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 2016Article
- Acute toxicity in comprehensive head and neck radiation for nasopharynx and paranasal sinus cancers: cohort comparison of 3D conformal proton therapy and intensity modulated radiation therapy.Radiation oncology (London, England) · 2016Article
Corrections and comments
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Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
purposeWe evaluated acute toxicity profiles and dosimetric data for children with salivary gland tumors treated with adjuvant photon/electron-based radiation therapy (X/E RT) or proton therapy (PRT). METHODS AND MATERIALS: We identified 24 patients who had received adjuvant radiotherapy for salivary gland tumors. Data were extracted from the medical records and the treatment planning systems. Toxicity was scored according to the Common Terminology Criteria for Adverse Effects 4.0.
resultsEleven patients received X/E RT and 13 PRT, with a median prescribed dose of 60 Gy in each group. In the X/E RT group, 54% of patients developed acute grade II/III dermatitis, 27% grade II/III dysphagia, and 91% grade II/III mucositis, and the median weight loss was 5.3% with one patient requiring feeding tube placement. In the PRT group, 53% had acute grade II/III dermatitis, 0% grade II/III dysphagia, and 46% grade II/III mucositis, with a median weight gain of 1.2%. Additionally, PRT was associated with lower mean doses to several normal surrounding midline and contralateral structures.
conclusionIn this retrospective study of pediatric salivary tumors, PRT was associated with a favorable acute toxicity and dosimetric profile. Continued follow-up is needed to identify long-term toxicity and survival data.
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