ArticleJournal of experimental & clinical cancer research : CR2015
Innovation in catheter design for intra-arterial liver cancer treatments results in favorable particle-fluid dynamics.
Article in Journal of experimental & clinical cancer research : CR, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Transarterial radioembolization: a systematic review on gaining control over the parameters that influence microsphere distribution.Drug delivery · 2023Pooled it
- Trial
- In Vitro Investigation of Microcatheter Behavior During Microsphere Injection in Transarterial Radioembolization.Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists · 2026Article
- Review
- Disphosphate based hydrogel microspheres for targeted transarterial radioembolization and chemoembolization therapies.Journal of advanced research · 2026Article
- Performance and Safety of a Reflux-Control Microcatheter Used to Perform DEB-TACE with LUMIJournal of clinical medicine · 2023Article
- Intravital tumor decellularization as a new approach to cancer treatment.American journal of cancer research · 2023Article
- Particle Distribution in Embolotherapy, How Do They Get There? A Critical Review of the Factors Affecting Arterial Distribution of Embolic Particles.Annals of biomedical engineering · 2022Review
- Computational study of a novel catheter for liver radioembolization.International journal for numerical methods in biomedical engineering · 2022Article
- Fluid-dynamic control microcatheter used with glue: preliminary experience on its feasibility and safety.La Radiologia medica · 2022Article
- Antireflux catheter improves tumor targeting in liver radioembolization with resin microspheres.Diagnostic and interventional radiology (Ankara, Turkey) · 2021Article
- Realistic boundary conditions in SimVascular through inlet catheter modeling.BMC research notes · 2021Article
- Multiscale Computational Fluid Dynamics Modeling for Personalized Liver Cancer Radioembolization Dosimetry.Journal of biomechanical engineering · 2021Article
- "Primum Non Nocere" in Interventional Oncology for Liver Cancer: How to Reduce the Risk for Complications?Life (Basel, Switzerland) · 2020Review
- End-hole Versus Microvalve Infusion Catheters in Patients Undergoing Drug-Eluting Microspheres-TACE for Solitary Hepatocellular Carcinoma Tumors: A Retrospective Analysis.Cardiovascular and interventional radiology · 2019Article
- Safety analysis of holmium-166 microsphere scout dose imaging during radioembolisation work-up: A cohort study.European radiology · 2018Article
- Evaluation of intraarterial and intravenous cisplatin chemotherapy in the treatment of metastatic osteosarcoma using an orthotopic xenograft mouse model.Journal of experimental & clinical cancer research : CR · 2016Article
- Negatively charged AuNP modified with monoclonal antibody against novel tumor antigen FAT1 for tumor targeting.Journal of experimental & clinical cancer research : CR · 2015Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver tumors are increasingly treated with radioembolization. Here, we present first evidence of catheter design effect on particle-fluid dynamics and downstream branch targeting during microsphere administrations. MATERIALS AND
methodsA total of 7 experiments were performed in a bench-top model of the hepatic arterial vasculature with recreated hemodynamics. Fluorescent microspheres and clinically used holmium microspheres were administered with a standard microcatheter (SMC) and an anti-reflux catheter (ARC) positioned at the same level along the longitudinal vessel axis. Catheter-related particle flow dynamics were analyzed by reviewing video recordings of UV-light illuminated fluorescent microsphere administrations. Downstream branch distribution was analyzed by quantification of collected microspheres in separate filters for two first-order branches. Mean deviation from a perfectly homogenous distribution (DHD) was used to compare the distribution homogeneity between catheter types.
resultsThe SMC administrations demonstrated a random off-centered catheter position (in 71 % of experiments), and a laminar particle flow pattern with an inhomogeneous downstream branch distribution, dependent on catheter position and injection force. The ARC administrations demonstrated a fixed centro-luminal catheter position, and a turbulent particle flow pattern with a more consistent and homogenous downstream branch distribution. Quantitative analyses confirmed a significantly more homogeneous distribution with the ARC; the mean DHD was 40.85 % (IQR 22.76 %) for the SMC and 15.54 % (IQR 6.46 %) for the ARC (p = 0.047).
conclusionCatheter type has a significant impact on microsphere administrations in an in-vitro hepatic arterial model. A within-patient randomized controlled trial has been initiated to investigate clinical catheter-related effects during radioembolization treatment.
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