Evidence map›Paper›PMID 26231884›Full record

Trial reportEuropean heart journal2016

Exercise training improves peak oxygen consumption and haemodynamics in patients with severe pulmonary arterial hypertension and inoperable chronic thrombo-embolic pulmonary hypertension: a prospective, randomized, controlled trial.

Nicola Ehlken, Mona Lichtblau, Hans Klose, Johannes Weidenhammer, Christine Fischer, Robert Nechwatal, Sören Uiker, Michael Halank, Karen Olsson, Werner Seeger and 9 more

4 registry-linked trialsOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European heart journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 104 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 8 pooled it
16.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01393327 nacompletednot on this map

Feasibility and Influence of Respiratory and Exercise Therapy on Oxygen Uptake, Quality of Life and Right Heart Function in Chronic Thromboembolic Pulmonary Hypertension After Thromboendarterectomy

TypeinterventionalSponsorHeidelberg UniversityRan2010 to 2013Enrolled45ConditionsCTEPHArmsrespiratory and exercise therapy
NCT03345212 nacompletednot on this map

Implementation and Effect of Exercise and Respiratory Training on 6-minute Walking Distance in Patients With Severe Chronic Pulmonary Hypertension: a Randomized Controlled Multicenter Trial in European Countries

TypeinterventionalSponsorHeidelberg UniversityRan2016 to 2019Enrolled129ConditionsPulmonary HypertensionArmsExercise training
NCT04241497 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Home-based Exercise Training in Patients With Pulmonary Arterial Hypertension: Effect on Skeletal Muscular Function and Metabolism

TypeinterventionalSponsorLaval UniversityRan2020 to 2021Enrolled10ConditionsPulmonary Arterial Hypertension, Exercise Training, Home-based Rehabilitation, Exercise CapacityArmsHome-based rehabilitation
NCT05655481 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Effects of a Home Telerehabilitation Program Via Videoconference in Patients With Pulmonary Arterial Hypertension- Randomized Clinical Trial

TypeinterventionalSponsorUniversity of Nove de JulhoRan2023 to 2025Enrolled50ConditionsPulmonary Arterial Hypertension, Cardiovascular Diseases, Respiratory Disease Nursing, Hypertension, PulmonaryArmsAerobic and Resistance training with rehabilitation, Health education
3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 8 syntheses or guidelines pooled it, 241 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Effectiveness and safety of home-basedEuropean respiratory review : an official journal of the European Respiratory Society · 2025
    Pooled it
  4. Exercise-based rehabilitation programmes for pulmonary hypertension.The Cochrane database of systematic reviews · 2023
    Pooled it
  5. Pooled it
  6. Pooled it
  7. Pooled it
  8. Exercise-based rehabilitation programmes for pulmonary hypertension.The Cochrane database of systematic reviews · 2017
    Pooled it
  9. Trial
  10. Trial
  11. Trial
  12. Trial
  13. Trial
  14. Trial
  15. Article
  16. Review
  17. Article
  18. Right ventricular function in pulmonary hypertension and obesity: a cross-sectional cohort study with survival follow-up.Clinical research in cardiology : official journal of the German Cardiac Society · 2026
    Article
  19. Article
  20. Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 2 countries.

Nicola EhlkenCenter for Pulmonary Hypertension Thoraxclinic, University Hospital Heidelberg, Amalienstrasse 5, Heidelberg D-69126, Germany nicola.ehlken@med.uni-heidelberg.de.
Mona LichtblauCenter for Pulmonary Hypertension Thoraxclinic, University Hospital Heidelberg, Amalienstrasse 5, Heidelberg D-69126, Germany.
Hans KloseDepartment of Pneumology, University of Hamburg, Hamburg, Germany.
Johannes WeidenhammerCenter for Pulmonary Hypertension Thoraxclinic, University Hospital Heidelberg, Amalienstrasse 5, Heidelberg D-69126, Germany.
Christine FischerInstitute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
Robert NechwatalRehabilitation Center Koenigstuhl, Heidelberg, Germany.
Sören UikerRehabilitation Center Koenigstuhl, Heidelberg, Germany.
Michael HalankDepartment of Pneumology, University of Dresden, Dresden, Germany.
Karen OlssonDepartment of Pneumology, Hanover Medical School, Hanover, Germany.
Werner SeegerDepartment of Pneumology, University of Gießen, Gießen, Germany.
Henning GallDepartment of Pneumology, University of Gießen, Gießen, Germany.
Stephan RosenkranzDepartment of Cardiology, Cologne, Germany.
Heinrike WilkensDepartment of Pneumology, University of Homburg, Homburg, Germany.
Dirk MertensDepartment of Pneumology, University of Mainz, Mainz, Germany.
Hans-Jürgen SeyfarthDepartment of Pneumology, University of Leipzig, Leipzig, Germany.
Christian OpitzDRK Hospital-Westend, Berlin, Germany.
Silvia UlrichClinic of Pulmonology, University Hospital Zurich, Switzerland.
Benjamin EgenlaufCenter for Pulmonary Hypertension Thoraxclinic, University Hospital Heidelberg, Amalienstrasse 5, Heidelberg D-69126, Germany.
Ekkehard GrünigCenter for Pulmonary Hypertension Thoraxclinic, University Hospital Heidelberg, Amalienstrasse 5, Heidelberg D-69126, Germany.
University Hospital Heidelberg · DEHeidelberg University · DEStiftung Rehabilitation Heidelberg (Germany) · DEUniversity of Giessen · DEDRK Kliniken Berlin · DEJohannes Gutenberg University Mainz · DEMedizinische Hochschule Hannover · DETU Dresden · DEUniversität Hamburg · DEUniversity Hospital of Zurich · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsThe impact of exercise training on the right heart and pulmonary circulation has not yet been invasively assessed in patients with pulmonary hypertension (PH) and right heart failure. This prospective randomized controlled study investigates the effects of exercise training on peak VO2/kg, haemodynamics, and further clinically relevant parameters in PH patients. METHODS AND

resultsEighty-seven patients with pulmonary arterial hypertension and inoperable chronic thrombo-embolic PH (54% female, 56 ± 15 years, 84% World Health Organization functional class III/IV, 53% combination therapy) on stable disease-targeted medication were randomly assigned to a control and training group. Medication remained unchanged during the study period. Non-invasive assessments and right heart catheterization at rest and during exercise were performed at baseline and after 15 weeks. Primary endpoint was the change in peak VO2/kg. Secondary endpoints included changes in haemodynamics. For missing data, multiple imputation and responder analyses were performed. The study results showed a significant improvement of peak VO2/kg in the training group (difference from baseline to 15 weeks: training +3.1 ± 2.7 mL/min/kg equals +24.3% vs. control -0.2 ± 2.3 mL/min/kg equals +0.9%, P < 0.001). Cardiac index (CI) at rest and during exercise, mean pulmonary arterial pressure, pulmonary vascular resistance, 6 min walking distance, quality of life, and exercise capacity significantly improved by exercise training.

conclusionLow-dose exercise training at 4-7 days/week significantly improved peak VO2/kg, haemodynamics, and further clinically relevant parameters. The improvements of CI at rest and during exercise indicate that exercise training may improve the right ventricular function. Further, large multicentre trials are necessary to confirm these results.

Indexed as

Analysis of VarianceBiomarkersCardiac OutputChronic DiseaseExercise TestExercise TherapyExercise ToleranceFemaleHeart RateHumansHypertension, PulmonaryMaleMiddle AgedNatriuretic Peptide, BrainOxygen ConsumptionPeptide FragmentsBiomarkersNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)Cardiac indexCardiac outputCardiac rehabilitationPulmonary hypertensionRight heart catheterization

Identifiers

PMID26231884
PMCPMC4692286
OpenAlexW971975809

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.