Trial reportAmerican journal of preventive medicine2015
Alcohol Use, Partner Violence, and Depression: A Cluster Randomized Controlled Trial Among Urban South African Mothers Over 3 Years.
Trial report in American journal of preventive medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 9 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 9 syntheses or guidelines pooled it.
- How effective are community health workers in managing and preventing perinatal depression in sub-Saharan Africa? A systematic review of quantitative evidence.Health policy and planning · 2026Pooled it
- Psychosocial and medication interventions to stop or reduce alcohol consumption during pregnancy.The Cochrane database of systematic reviews · 2024Pooled it
- Psychosocial and pharmacologic interventions to reduce harmful alcohol use in low- and middle-income countries.The Cochrane database of systematic reviews · 2023Pooled it
- Patient-level interventions to reduce alcohol-related harms in low- and middle-income countries: A systematic review and meta-summary.PLoS medicine · 2022Pooled it
- Pooled it
- Effectiveness of psychosocial interventions for reducing parental substance misuse.The Cochrane database of systematic reviews · 2021Pooled it
- Psychosocial interventions for reducing alcohol consumption in sub-Saharan African settings: a systematic review and meta-analysis.Addiction (Abingdon, England) · 2021Pooled it
- Psychological therapies for women who experience intimate partner violence.The Cochrane database of systematic reviews · 2020Pooled it
- Psychosocial interventions for intimate partner violence in low and middle income countries: A meta-analysis of randomised controlled trials.Journal of global health · 2020Pooled it
- Testing an Incentive-Based and Community Health Worker Package Intervention to Improve Maternal Health and Nutrition Outcomes: A Pilot Randomized Controlled Trial.Maternal and child health journal · 2021Trial
- Home Visiting and Antenatal Depression Affect the Quality of Mother and Child Interactions in South Africa.Journal of the American Academy of Child and Adolescent Psychiatry · 2019Trial
- The association of maternal alcohol use and paraprofessional home visiting with children's health: A randomized controlled trial.Journal of consulting and clinical psychology · 2019Trial
- An Incentive-Based and Community Health Worker Package Intervention to Improve Early Utilization of Antenatal Care: Evidence from a Pilot Randomised Controlled Trial.Maternal and child health journal · 2019Trial
- Trial
- Food insufficiency, depression, and the modifying role of social support: Evidence from a population-based, prospective cohort of pregnant women in peri-urban South Africa.Social science & medicine (1982) · 2016Trial
- Intimate Partner Violence and Depression Symptom Severity among South African Women during Pregnancy and Postpartum: Population-Based Prospective Cohort Study.PLoS medicine · 2016Trial
- Components of Family-Focused Interventions that Have Common Impacts Across Parental Domestic Violence and Abuse, Mental Ill-Health, and Substance Misuse: An Intervention Components Analysis.Journal of prevention (2022) · 2026Article
- Socio-economic indicators, housing characteristics, site of residence, and substance use as household-level risk factors in GRT-INSPIRED communities.Frontiers in public health · 2026Article
- Community-Based Adaptation and Evaluation of a Peer-Led Intervention to Address Alcohol Use and HIV in Pregnant and Breastfeeding Women in South Africa: Protocol for the "Mentor Mothers Plus" Randomized Control Trial.JMIR research protocols · 2025Article
- Investigative Approaches to Resilient Emotion Regulation Neurodevelopment in a South African Birth Cohort.Biological psychiatry global open science · 2025Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
introductionPregnant South African women with histories of drinking alcohol, abuse by violent partners, depression, and living with HIV are likely to have their post-birth trajectories over 36 months significantly influenced by these risks.
designAll pregnant women in 24 Cape Town neighborhoods were recruited into a cluster RCT by neighborhood to either: (1) a standard care condition (n=12 neighborhoods, n=594 mothers); or (2) a home-visiting intervention condition (n=12 neighborhoods, n=644 mothers). SETTING/
participantsPregnant women residing in urban, low-income neighborhoods in Cape Town, South Africa.
interventionHome visiting included prenatal and postnatal visits by community health workers (Mentor Mothers) focusing on general maternal and child health, HIV/tuberculosis, alcohol use, and nutrition.
main outcome measuresMothers were assessed in pregnancy and at 18 and 36 months post birth: 80.6% of mothers completed all assessments between 2009 and 2014 and were included in these analyses performed in 2014. Longitudinal structural equation modeling examined alcohol use, partner violence, and depression at the baseline and 18-month interviews as predictors of maternal outcomes at 36 months post birth.
resultsRelative to standard care, intervention mothers were significantly less likely to report depressive symptoms and more positive quality of life at 36 months. Alcohol use was significantly related to use over time, but was also related to depression and HIV status at each assessment and partner violence at 36 months.
conclusionsAlcohol, partner violence, and depression are significantly related over time. A home-visiting intervention improved the emotional health of low-income mothers even when depression was not initially targeted.
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