ArticleApplied and environmental microbiology2015
Identification and Characterization of a Novel Staphylococcal Emetic Toxin.
Article in Applied and environmental microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 106 citations in OpenAlex.
- The Pathogenicity Mechanisms ofInternational journal of molecular sciences · 2025Review
- Preliminary assessment of the therapeutic potential of staphylococcal enterotoxin-like W via biological activity and TCR binding sites analysis.Virulence · 2025Article
- Prevalence, virulence factors, and antibiotic resistance of Staphylococcus aureus in seafood products.BMC infectious diseases · 2025Article
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- Novel insights into the immune response to bacterial T cell superantigens.Nature reviews. Immunology · 2024Review
- Rapid detection of major enterotoxin genes and antibiotic resistance of Staphylococcus aureus isolated from raw milk in the Yazd province, Iran.Veterinary medicine and science · 2024Article
- Review
- Coordination of prophage and global regulator leads to high enterotoxin production in staphylococcal food poisoning-associated lineage.Microbiology spectrum · 2024Article
- Identification of the Enterotoxigenic Potential ofToxins · 2023Article
- Molecular Characteristics and Pathogenicity ofInternational journal of molecular sciences · 2023Review
- First Report of Food Poisoning Due to Staphylococcal Enterotoxin Type B in Döner Kebab (Italy).Pathogens (Basel, Switzerland) · 2023Article
- Prevalence, antimicrobial resistance, and staphylococcal toxin genes of blaVeterinary medicine and science · 2023Article
- Superantigens, a Paradox of the Immune Response.Toxins · 2022Review
- Regulatory and Enterotoxin Gene Expression and Enterotoxins Production inInternational journal of molecular sciences · 2022Article
- Article
- Highly Sensitive and Specific Detection of Staphylococcal Enterotoxins SEA, SEG, SEH, and SEI by Immunoassay.Toxins · 2021Article
- Review
- Review
- Article
- Staphylococcus aureus Isolated from Skin from Atopic-Dermatitis Patients Produces Staphylococcal Enterotoxin Y, Which Predominantly Induces T-Cell Receptor Vα-Specific Expansion of T Cells.Infection and immunity · 2020Article
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Authors and funding
11 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Staphylococcal enterotoxins (SEs) produced by Staphylococcus aureus have superantigenic and emetic activities, which cause toxic shock syndrome and staphylococcal food poisoning, respectively. Our previous study demonstrated that the sequence of SET has a low level of similarity to the sequences of other SEs and exhibits atypical bioactivities. Hence, we further explored whether there is an additional SET-related gene in S. aureus strains. One SET-like gene was found in the genome of S. aureus isolates that originated from a case of food poisoning, a human nasal swab, and a case of bovine mastitis. The deduced amino acid sequence of the SET-like gene showed 32% identity with the amino acid sequence of SET. The SET-like gene product was designated SElY. In the food poisoning and nasal swab isolates, mRNA encoding SElY was highly expressed in the early log phase of cultivation, whereas a high level of expression of this mRNA was found in the bovine mastitis isolate at the early stationary phase. To estimate whether SElY has both superantigenic and emetic activities, recombinant SElY was prepared. Cell proliferation and cytokine production were examined to assess the superantigenic activity of SElY. SElY exhibited superantigenic activity in human peripheral blood mononuclear cells but not in mouse splenocytes. In addition, SElY exhibited emetic activity in house musk shrews after intraperitoneal and oral administration. However, the stability of SElY against heating and pepsin and trypsin digestion was different from that of SET and SEA. From these results, we identified SElY to be a novel staphylococcal emetic toxin.
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