ReviewCurrent environmental health reports2015
Oral Chromium Exposure and Toxicity.
Review in Current environmental health reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
79 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Human Health Effects of Oral Exposure to Chromium: A Systematic Review of the Epidemiological Evidence.International journal of environmental research and public health · 2024Pooled it
- Method and mechanism of chromium removal from soil: a systematic review.Environmental science and pollution research international · 2022Pooled it
- Relationships Between Biological Heavy Metals and Breast Cancer: A Systematic Review and Meta-Analysis.Frontiers in nutrition · 2022Pooled it
- Metal(loid) Occurrence, Possible Source Patterns, and Screening-Level Human Health Risk in Dried Fish from Thailand.Biological trace element research · 2026Article
- Chromium-Doped Magnetite Nanoparticles for Permanganate Ion Removal: Advances in Environmental Remediation.ACS omega · 2026Article
- Prospects for the Use of MICP Technology in the Remediation of Saline-Alkaline Soil Heavy Metal Pollution.Microorganisms · 2026Review
- Mechanism of Liver Injury Induced by CrAnimals : an open access journal from MDPI · 2026Article
- Heavy Metal Ion Removal: A Global Review of Wastewater Treatment Technologies.International journal of molecular sciences · 2026Review
- The Values of Potentially Toxic Elements (PTEs) in Prescription and Non-prescription Dry Cat and Dog Diets in Turkey.Biological trace element research · 2026Article
- Sustainable strategies for remediation of Cr(VI) contaminated soil and water bodies: exploring the potential of invasive bamboo and its derivatives.Frontiers in plant science · 2026Review
- Cancer and Environmental Xenobiotics: Mechanisms, Controversies, and Innovations.Journal of xenobiotics · 2025Review
- Analytical Determination of Heavy Metals in Water Using Carbon-Based Materials.Molecules (Basel, Switzerland) · 2025Review
- A review of the sidelined pollutant: Reviving the fight against heavy metal contamination in an era of emerging contaminants.Toxicology reports · 2025Review
- Long-Term Impact of Cr(VI) Exposure in Swiss Albino Mice: ROS-Driven Modulation of Autophagy and Cellular Fate.Biological trace element research · 2025Article
- Exposure to low levels of hexavalent chromium in drinking water alters diet-induced steatotic liver disease in male rats.Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) · 2025Article
- Study the effect of olive extracts on chromium (VI) induced neuro-histo-toxicological defects in adult male albino rats.Toxicology research · 2025Article
- Comprehensive heavy metal remediation mechanisms with insights into CRISPR-Cas9 and biochar innovations.Biodegradation · 2025Review
- Polyethylene terephthalate nanoplastics-induced neurotoxicity in adult male Swiss albino mice with amelioration of betaine: a histopathological, neurochemical, and molecular investigation.Naunyn-Schmiedeberg's archives of pharmacology · 2025Article
- Carrageenan@Graphene Oxide Nanocomposites for the Adsorption of Trivalent Arsenic, Hexavalent Chromium, and Fluoride Ions from Aqueous Solutions: Conceptualization Modeling of Adsorptive Interfacial Interactions, Kinetics, and Swelling.Langmuir : the ACS journal of surfaces and colloids · 2025Article
- Article
19 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Hexavalent chromium [Cr(VI)] is a known carcinogen when inhaled. However, inhalational exposure to Cr(VI) affects only a small portion of the population, mainly by occupational exposures. In contrast, oral exposure to Cr(VI) is widespread and affects many people throughout the globe. In 2008, the National Toxicology Program (NTP) released a 2-year study demonstrating that ingested Cr(VI) was carcinogenic in rats and mice. The effects of Cr(VI) oral exposure are mitigated by reduction in the gut; however, a portion evades the reductive detoxification and reaches target tissues. Once Cr(VI) enters the cell, it ultimately gets reduced to Cr(III), which mediates its toxicity via induction of oxidative stress during the reduction while Cr intermediates react with protein and DNA. Cr(III) can form adducts with DNA that may lead to mutations. This review will discuss the potential adverse effects of oral exposure to Cr(VI) by presenting up-to-date human and animal studies, examining the underlying mechanisms that mediate Cr(VI) toxicity, as well as highlighting opportunities for future research.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.