ArticleAmerican journal of ophthalmology2015
Longitudinal Change of Circumpapillary Retinal Nerve Fiber Layer Thickness in Children With Optic Pathway Gliomas.
Article in American journal of ophthalmology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers, 2 of them syntheses that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
35 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of systemic anticancer therapy in pediatric optic pathway glioma on visual function: A systematic review.PloS one · 2021Pooled it
- Pooled it
- Long-term outcomes after a randomized phase II trial of nerve growth factor eye drops for optic pathway gliomas: four-year follow-up findings in children.Journal of neuro-oncology · 2026Trial
- Pediatric Optic Pathway Gliomas: Diagnosis, Management, and Outcomes.International ophthalmology clinics · 2026Review
- Visual outcome including visual field defects after treatment of paediatric optic pathway glioma: A nationwide cohort study.Acta ophthalmologica · 2025Article
- Correlation between retinal nerve fibre layer thickness and tumour volume in patients with optic pathway gliomas.International ophthalmology · 2025Article
- Visual Deficits and Diagnostic and Therapeutic Strategies for Neurofibromatosis Type 1: Bridging Science and Patient-Centered Care.Vision (Basel, Switzerland) · 2024Review
- Article
- Ophthalmologic Findings in Children with Neurofibromatosis Type 1.Neuro-ophthalmology (Aeolus Press) · 2024Article
- Optic Pathway Gliomas in Pediatric Population-Current Approach in Diagnosis and Management: Literature Review.Journal of clinical medicine · 2023Review
- Neurofibromatosis Type 1-Associated Optic Pathway Gliomas: Current Challenges and Future Prospects.Cancer management and research · 2023Review
- Optical Coherence Tomography Significance in Managing Early Onset of Optic Pathway Gliomas in Children Younger than 5 Years of Age-A Retrospective Study.Children (Basel, Switzerland) · 2022Article
- Handheld optical coherence tomography removes barriers to imaging the eyes of young children.Eye (London, England) · 2022Article
- Current update on the visual outcome of optic pathway glioma associated with neurofibromatosis type-1.Frontiers in surgery · 2022Review
- Inner and outer retinal layer thickness alterations in pediatric and juvenile craniopharyngioma.Scientific reports · 2021Article
- Optic Nerve Gliomas.Journal of neurological surgery. Part B, Skull base · 2021Article
- Optical coherence tomography in adult adrenoleukodystrophy: a cross-sectional and longitudinal study.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Optical coherence tomography (OCT) in neuro-ophthalmology.Eye (London, England) · 2021Review
- Visual function tests including the role of optical coherence tomography in neurofibromatosis 1.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020Review
- Profile of macular ganglion cell-inner plexiform layer thickness in healthy 6.5 year- old Swedish children.BMC ophthalmology · 2020Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
purposeTo evaluate longitudinal changes in circumpapillary retinal nerve fiber layer (RNFL) thickness, as measured by spectral-domain optical coherence tomography (SD OCT), in children with optic pathway gliomas.
designLongitudinal cohort study.
methodsGlobal and quadrant-specific circumpapillary RNFL thickness measures were acquired using either a hand-held SD OCT during sedation or a table-top SD OCT in children old enough to cooperate. Vision loss was defined as either a 0.2 logMAR decline in visual acuity or progression of visual field. Percent change in circumpapillary RNFL thickness in eyes experiencing vision loss was compared to eyes with stable vision.
resultsFifty-five eyes completed 250 study visits. Ten eyes (18%) from 7 patients experienced a new episode of vision loss during the study and 45 eyes (82%) from 39 patients demonstrated stable vision across study visits. Percent decline of RNFL thickness between the baseline visit and first event of vision loss event was greatest in the superior (-14%) and inferior (-10%) quadrants as well as global average (-13%). Using a threshold of ≥10% decline in RNFL, the positive and negative predictive value for vision loss when 2 or more anatomic sectors were affected was 100% and 94%, respectively.
conclusionsChildren experiencing vision loss from their optic pathway gliomas frequently demonstrate a ≥10% decline of RNFL thickness in 1 or more anatomic sectors. Global average and the inferior quadrant demonstrated the best positive and negative predictive values. Circumpapillary RNFL is a surrogate marker of vision and could be helpful in making treatment decisions for children with optic pathway gliomas.
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