Evidence map›Paper›PMID 26231260›Full record

ReviewNeurology2015

Pediatric cavernous sinus thrombosis: A case series and review of the literature.

Douglas M Smith, Arastoo Vossough, Gregory A Vorona, Lauren A Beslow, Rebecca N Ichord, Daniel J Licht

Open access · bronzeAbstract readCase ReportsReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 55 citations in OpenAlex.

  1. Article
  2. Article
  3. CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021
    Article
  4. Cavernous sinus thrombosis related to sphenoid sinusitis in a child.CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2021
    Article
  5. Article
  6. Article
  7. Intracranial abscesses in children at Ile-Ife, Nigeria: a case series and review of literature.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2020
    Review
  8. Article
  9. Article
  10. Prognosis of septic cavernous sinus thrombosis remarkably improved: a case series of 12 patients and literature review.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018
    Review
  11. Cerebral Sinovenous Thrombosis.Frontiers in pediatrics · 2017
    Review
  12. Cavernous Sinus Thrombosis in Children.Pediatric neurology briefs · 2016
    Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Douglas M SmithFrom the Division of Neurology (D.M.S., R.N.I., D.J.L.) and the Department of Radiology (A.V.), Children's Hospital of Philadelphia, PA; the Department of Neurology (D.M.S., R.N.I., D.J.L.), Perelman School of Medicine of the University of Pennsylvania; the Department of Radiology (A.V.), Hospital of the University of Pennsylvania, Philadelphia; Children's Hospital of Richmond at VCU (G.A.V.), VA; and the Departments of Pediatrics and Neurology (L.A.B.), Yale University School of Medicine, New Haven, CT. smithd13@email.chop.edu.
Arastoo VossoughFrom the Division of Neurology (D.M.S., R.N.I., D.J.L.) and the Department of Radiology (A.V.), Children's Hospital of Philadelphia, PA; the Department of Neurology (D.M.S., R.N.I., D.J.L.), Perelman School of Medicine of the University of Pennsylvania; the Department of Radiology (A.V.), Hospital of the University of Pennsylvania, Philadelphia; Children's Hospital of Richmond at VCU (G.A.V.), VA; and the Departments of Pediatrics and Neurology (L.A.B.), Yale University School of Medicine, New Haven, CT.
Gregory A VoronaFrom the Division of Neurology (D.M.S., R.N.I., D.J.L.) and the Department of Radiology (A.V.), Children's Hospital of Philadelphia, PA; the Department of Neurology (D.M.S., R.N.I., D.J.L.), Perelman School of Medicine of the University of Pennsylvania; the Department of Radiology (A.V.), Hospital of the University of Pennsylvania, Philadelphia; Children's Hospital of Richmond at VCU (G.A.V.), VA; and the Departments of Pediatrics and Neurology (L.A.B.), Yale University School of Medicine, New Haven, CT.
Lauren A BeslowFrom the Division of Neurology (D.M.S., R.N.I., D.J.L.) and the Department of Radiology (A.V.), Children's Hospital of Philadelphia, PA; the Department of Neurology (D.M.S., R.N.I., D.J.L.), Perelman School of Medicine of the University of Pennsylvania; the Department of Radiology (A.V.), Hospital of the University of Pennsylvania, Philadelphia; Children's Hospital of Richmond at VCU (G.A.V.), VA; and the Departments of Pediatrics and Neurology (L.A.B.), Yale University School of Medicine, New Haven, CT.
Rebecca N IchordFrom the Division of Neurology (D.M.S., R.N.I., D.J.L.) and the Department of Radiology (A.V.), Children's Hospital of Philadelphia, PA; the Department of Neurology (D.M.S., R.N.I., D.J.L.), Perelman School of Medicine of the University of Pennsylvania; the Department of Radiology (A.V.), Hospital of the University of Pennsylvania, Philadelphia; Children's Hospital of Richmond at VCU (G.A.V.), VA; and the Departments of Pediatrics and Neurology (L.A.B.), Yale University School of Medicine, New Haven, CT.
Daniel J LichtFrom the Division of Neurology (D.M.S., R.N.I., D.J.L.) and the Department of Radiology (A.V.), Children's Hospital of Philadelphia, PA; the Department of Neurology (D.M.S., R.N.I., D.J.L.), Perelman School of Medicine of the University of Pennsylvania; the Department of Radiology (A.V.), Hospital of the University of Pennsylvania, Philadelphia; Children's Hospital of Richmond at VCU (G.A.V.), VA; and the Departments of Pediatrics and Neurology (L.A.B.), Yale University School of Medicine, New Haven, CT.
Hospital of the University of Pennsylvania · USUniversity of Pennsylvania · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo describe clinical characteristics, imaging findings, morbidity, and mortality in a single-center cohort of 12 pediatric cavernous sinus thrombosis cases and to review all cases available in recent English literature.

methodsClinical data and radiographic studies on 12 cases from our institution were analyzed retrospectively. A literature search and review was conducted, with additional cases pooled with the new cohort for an aggregate analysis.

resultsTwelve cases of cavernous sinus thrombosis in children from the Children's Hospital of Philadelphia between January 1, 2000, and December 31, 2013, were reviewed. All patients survived to discharge; 3 of 12 (25%) experienced neurologic morbidity. Contrast-enhanced MRI and contrast-enhanced head CT were 100% sensitive for detecting cavernous sinus thrombosis, while noncontrast time-of-flight magnetic resonance venography (TOF MRV) and noncontrast head CT were 0% sensitive. Literature review produced an additional 40 cases, and the aggregate mortality rate was 4 of 52 (8%) and morbidity rate was 10 of 40 (25%). Outcomes did not vary by treatment or with unilateral vs bilateral cavernous sinus involvement. There was a trend toward worse outcomes with fungal infections.

conclusionOur case series demonstrates low morbidity and mortality with early, aggressive surgical, antimicrobial, and anticoagulation therapies. Although anticoagulation and surgery were not associated with significantly different outcomes, more study is needed.

Indexed as

AdolescentCavernous Sinus ThrombosisCerebral AngiographyChildChild, PreschoolCohort StudiesFemaleHeadHumansMagnetic Resonance ImagingMaleRetrospective StudiesTomography, X-Ray Computed

Identifiers

PMID26231260
PMCPMC4553026
OpenAlexW2154958914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.