Evidence map›Paper›PMID 26231259›Full record

ArticleNeurology2015

N-terminal pro-brain natriuretic peptide and abnormal brain aging: The AGES-Reykjavik Study.

Behnam Sabayan, Mark A van Buchem, Anton J M de Craen, Sigurdur Sigurdsson, Qian Zhang, Tamara B Harris, Vilmundur Gudnason, Andrew E Arai, Lenore J Launer

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.5field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Cardiac Biomarkers, Subclinical Brain Vascular Changes, and Cognitive Decline: Post Hoc Analysis of the SPRINT Trial.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
    Trial
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  3. Heart-Brain Axis: Subclinical Cardiovascular Changes and Brain Health.Journal of the American Heart Association · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Behnam SabayanFrom the Departments of Radiology (B.S., M.A.v.B.) and Gerontology and Geriatrics (B.S., A.J.M.d.C.), Leiden University Medical Center, the Netherlands; Icelandic Heart Association (S.S., V.G.), Reykjavik, Iceland; Intramural Research Program (Q.Z., T.B.H., L.J.L.), National Institute on Aging, NIH, Bethesda, MD; Faculty of Medicine (V.G.), University of Iceland, Reykjavik; and Cardiovascular and Pulmonary Branch (A.E.A.), National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
Mark A van BuchemFrom the Departments of Radiology (B.S., M.A.v.B.) and Gerontology and Geriatrics (B.S., A.J.M.d.C.), Leiden University Medical Center, the Netherlands; Icelandic Heart Association (S.S., V.G.), Reykjavik, Iceland; Intramural Research Program (Q.Z., T.B.H., L.J.L.), National Institute on Aging, NIH, Bethesda, MD; Faculty of Medicine (V.G.), University of Iceland, Reykjavik; and Cardiovascular and Pulmonary Branch (A.E.A.), National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
Anton J M de CraenFrom the Departments of Radiology (B.S., M.A.v.B.) and Gerontology and Geriatrics (B.S., A.J.M.d.C.), Leiden University Medical Center, the Netherlands; Icelandic Heart Association (S.S., V.G.), Reykjavik, Iceland; Intramural Research Program (Q.Z., T.B.H., L.J.L.), National Institute on Aging, NIH, Bethesda, MD; Faculty of Medicine (V.G.), University of Iceland, Reykjavik; and Cardiovascular and Pulmonary Branch (A.E.A.), National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
Sigurdur SigurdssonFrom the Departments of Radiology (B.S., M.A.v.B.) and Gerontology and Geriatrics (B.S., A.J.M.d.C.), Leiden University Medical Center, the Netherlands; Icelandic Heart Association (S.S., V.G.), Reykjavik, Iceland; Intramural Research Program (Q.Z., T.B.H., L.J.L.), National Institute on Aging, NIH, Bethesda, MD; Faculty of Medicine (V.G.), University of Iceland, Reykjavik; and Cardiovascular and Pulmonary Branch (A.E.A.), National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
Qian ZhangFrom the Departments of Radiology (B.S., M.A.v.B.) and Gerontology and Geriatrics (B.S., A.J.M.d.C.), Leiden University Medical Center, the Netherlands; Icelandic Heart Association (S.S., V.G.), Reykjavik, Iceland; Intramural Research Program (Q.Z., T.B.H., L.J.L.), National Institute on Aging, NIH, Bethesda, MD; Faculty of Medicine (V.G.), University of Iceland, Reykjavik; and Cardiovascular and Pulmonary Branch (A.E.A.), National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
Tamara B HarrisFrom the Departments of Radiology (B.S., M.A.v.B.) and Gerontology and Geriatrics (B.S., A.J.M.d.C.), Leiden University Medical Center, the Netherlands; Icelandic Heart Association (S.S., V.G.), Reykjavik, Iceland; Intramural Research Program (Q.Z., T.B.H., L.J.L.), National Institute on Aging, NIH, Bethesda, MD; Faculty of Medicine (V.G.), University of Iceland, Reykjavik; and Cardiovascular and Pulmonary Branch (A.E.A.), National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
Vilmundur GudnasonFrom the Departments of Radiology (B.S., M.A.v.B.) and Gerontology and Geriatrics (B.S., A.J.M.d.C.), Leiden University Medical Center, the Netherlands; Icelandic Heart Association (S.S., V.G.), Reykjavik, Iceland; Intramural Research Program (Q.Z., T.B.H., L.J.L.), National Institute on Aging, NIH, Bethesda, MD; Faculty of Medicine (V.G.), University of Iceland, Reykjavik; and Cardiovascular and Pulmonary Branch (A.E.A.), National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
Andrew E AraiFrom the Departments of Radiology (B.S., M.A.v.B.) and Gerontology and Geriatrics (B.S., A.J.M.d.C.), Leiden University Medical Center, the Netherlands; Icelandic Heart Association (S.S., V.G.), Reykjavik, Iceland; Intramural Research Program (Q.Z., T.B.H., L.J.L.), National Institute on Aging, NIH, Bethesda, MD; Faculty of Medicine (V.G.), University of Iceland, Reykjavik; and Cardiovascular and Pulmonary Branch (A.E.A.), National Heart, Lung, and Blood Institute, NIH, Bethesda, MD.
Lenore J LaunerFrom the Departments of Radiology (B.S., M.A.v.B.) and Gerontology and Geriatrics (B.S., A.J.M.d.C.), Leiden University Medical Center, the Netherlands; Icelandic Heart Association (S.S., V.G.), Reykjavik, Iceland; Intramural Research Program (Q.Z., T.B.H., L.J.L.), National Institute on Aging, NIH, Bethesda, MD; Faculty of Medicine (V.G.), University of Iceland, Reykjavik; and Cardiovascular and Pulmonary Branch (A.E.A.), National Heart, Lung, and Blood Institute, NIH, Bethesda, MD. launerl@nia.nih.gov.
Icelandic Heart Association · ISNational Institute on Aging · USUniversity of Iceland · IS

Funding

Technical Development of Diagnostic Cardiovascular MRIZIAHL004607 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ARAI, ANDREW · 2009 to 2020
$25.3M
Clinical Advanced Cardiovascular ImagingZIDHL006140 · NHLBI · NATIONAL HEART, LUNG, AND BLOOD INSTITUTE · PI ARAI, ANDREW · 2011 to 2020
$8.2M
Brain aging and cardiovascular risk factors and diseaseZIAAG007480 · NIA · NATIONAL INSTITUTE ON AGING · PI LAUNER, LENORE J · 2011 to 2025
$2.7M
AGES STUDY-THE REYKJAVIK STUDY OF HEALTHY AGING FOR THE NEW MILLENNIUM-26012100N01AG012100 · NIA · ICELANDIC HEART ASSOCIATION · 2002 to 2004
–
NCIPC CDC HHS Z01 HL004607-08 CENIA NIH HHS N01-AG-12100
6 · The paper itself

Abstract

objectiveTo investigate the independent association of serum N-terminal fragment of the prohormone natriuretic peptide (NT-proBNP) with structural and functional features of abnormal brain aging in older individuals.

methodsIn this cross-sectional study based on the Age, Gene/Environment Susceptibility (AGES)-Reykjavik Study, we included 4,029 older community-dwelling individuals (born 1907 to 1935) with a measured serum level of NT-proBNP. Outcomes included parenchymal brain volumes estimated from brain MRI, cognitive function measured by tests of memory, processing speed, and executive functioning, and presence of depressive symptoms measured using the Geriatric Depression Scale. In a substudy, cardiac output of 857 participants was assessed using cardiac MRI.

resultsIn multivariate analyses, adjusted for sociodemographic and cardiovascular factors, higher levels of NT-proBNP were independently associated with lower total (p < 0.001), gray matter (p < 0.001), and white matter (p = 0.001) brain volumes. Likewise, in multivariate analyses, higher levels of NT-proBNP were associated with worse scores in memory (p = 0.005), processing speed (p = 0.001), executive functioning (p < 0.001), and more depressive symptoms (p = 0.002). In the substudy, the associations of higher NT-proBNP with lower brain parenchymal volumes, impaired executive function and processing speed, and higher depressive symptoms were independent of the level of cardiac output.

conclusionsHigher serum levels of NT-proBNP, independent of cardiovascular risk factors and a measure of cardiac function, are linked with alterations in brain structure and function. Roles of natriuretic peptides in the process of brain aging need to be further elucidated.

Indexed as

AgedAgingBrainCardiovascular DiseasesCognitionCross-Sectional StudiesDepressionFemaleGray MatterHeart Function TestsHumansMagnetic Resonance ImagingMaleMultivariate AnalysisNatriuretic Peptide, BrainNeuropsychological TestsNatriuretic Peptide, BrainPeptide Fragmentspro-brain natriuretic peptide (1-76)

Identifiers

PMID26231259
PMCPMC4553023
OpenAlexW1786449332

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.