Evidence map›Paper›PMID 26231222›Full record

ArticleHuman molecular genetics2015

Shared genetics underlying epidemiological association between endometriosis and ovarian cancer.

Yi Lu, Gabriel Cuellar-Partida, Jodie N Painter, Dale R Nyholt, Australian Ovarian Cancer Study, International Endogene Consortium (IEC), Andrew P Morris, Peter A Fasching, Alexander Hein, Stefanie Burghaus and 103 more

Open access · bronzeAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Human molecular genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 2 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Endometriosis: An Immunologist's Perspective.International journal of molecular sciences · 2025
    Review
  5. Cellular origins of mucinous ovarian carcinoma.The Journal of pathology · 2025
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Different Influences of Endometriosis and Pelvic Inflammatory Disease on the Occurrence of Ovarian Cancer.International journal of environmental research and public health · 2021
    Article
  19. Article
  20. Experimental and therapeutic medicine · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

113 authors at 20 institutions in 13 countries.

Yi LuStatistical Genetics.
Gabriel Cuellar-PartidaStatistical Genetics.
Jodie N PainterMolecular Cancer Epidemiology.
Dale R NyholtInstitute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia.
Australian Ovarian Cancer Study
International Endogene Consortium (IEC)
Andrew P MorrisGenetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics and Department of Biostatistics, University of Liverpool, Liverpool, UK.
Peter A FaschingDivision of Hematology and Oncology, Department of Medicine, David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA, USA, Department of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Alexander HeinDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Stefanie BurghausDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Matthias W BeckmannDepartment of Gynecology and Obstetrics, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen Nuremberg, Universitaetsstrasse 21-23, 91054 Erlangen, Germany.
Diether LambrechtsLaboratory for Translational Genetics, Department of Oncology, University of Leuven, Leuven, Belgium, Vesalius Research Center, VIB, Leuven, Belgium.
Els Van NieuwenhuysenDivision of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Ignace VergoteDivision of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Adriaan VandersticheleDivision of Gynecologic Oncology, Department of Obstetrics and Gynaecology and Leuven Cancer Institute, University Hospitals Leuven, Leuven, Belgium.
Jennifer Anne DohertyDepartment of Community and Family Medicine, Section of Biostatistics & Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover, NH, USA.
Mary Anne RossingDepartment of Epidemiology, University of Washington, Seattle, WA, USA, Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Kristine G WicklundProgram in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.
Jenny Chang-ClaudeDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Ursula EilberDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Anja RudolphDivision of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany.
Shan Wang-GohrkeDepartment of Obstetrics and Gynecology, University of Ulm, Ulm, Germany.
Marc T GoodmanCancer Prevention and Control, Samuel Oschin Comprehensive Cancer Institute and Department of Biomedical Sciences, Community and Population Health Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Natalia BogdanovaRadiation Oncology Research Unit.
Thilo DörkGynaecology Research Unit and.
Matthias DürstDepartment of Gynecology, Jena-University Hospital-Friedrich Schiller University, Jena, Germany.
Peter HillemannsClinics of Obstetrics and Gynaecology, Hannover Medical School, Hannover, Germany.
Ingo B RunnebaumDepartment of Gynecology, Jena-University Hospital-Friedrich Schiller University, Jena, Germany.
Natalia AntonenkovaN.N. Alexandrov National Cancer Centre of Belarus, Minsk, Belarus.
Ralf ButzowDepartment of Pathology and.
Arto LeminenDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Heli NevanlinnaDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Liisa M PelttariDepartment of Obstetrics and Gynecology, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.
Robert P EdwardsDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA.
Joseph L KelleyDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Francesmary ModugnoDivision of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA, Womens Cancer Research Program, Magee-Womens Research Institute and University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA, Department of Epidemiology, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
Kirsten B MoysichDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
Roberta B NessThe University of Texas School of Public Health, Houston, TX, USA.
Rikki CanniotoDepartment of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, NY, USA.
Estrid HøgdallDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark, Molecular Unit, Department of Pathology, Herlev Hospital, Herlev, Denmark.
Allan JensenDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.
Graham G GilesDepartment of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Victoria, Australia, Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Fiona BruinsmaCancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia.
Susanne K KjaerDepartment of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark, Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Michelle A T HildebrandtDepartment of Epidemiology and.
Dong LiangCollege of Pharmacy and Health Sciences, Texas Southern University, Houston, TX, USA.
Karen H LuDepartment of Gynecologic Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Xifeng WuDepartment of Epidemiology and.
Maria BisognaGynecology Service, Department of Surgery and.
Fanny DaoGynecology Service, Department of Surgery and.
Douglas A LevineGynecology Service, Department of Surgery and.
Daniel W CramerObstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA.
Kathryn L TerryObstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital, Boston, MA, USA, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
Shelley S TworogerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Medicine and.
Stacey MissmerDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Medicine and Department of Obstetrics and Gynecology, Gynecology and Reproductive Biology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Line BjorgeDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.
Helga B SalvesenDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.
Reidun K KopperudDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.
Katharina BischofDepartment of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway, Department of Clinical Science, Centre for Cancer Biomarkers, University of Bergen, Bergen, Norway.
Katja K H AbenRadboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, The Netherlands, Netherlands Comprehensive Cancer Organisation, Utrecht, The Netherlands.
Lambertus A KiemeneyRadboud University Medical Centre, Radboud Institute for Health Sciences, Nijmegen, The Netherlands.
Leon F A G MassugerDepartment of Obstetrics and Gynaecology, Radboud Institute for Molecular Life Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Angela Brooks-WilsonCanada's Michael Smith Genome Sciences Centre and Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Burnaby, BC, Canada.
Sara H OlsonDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Valerie McGuireDepartment of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA.
Joseph H RothsteinDepartment of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA.
Weiva SiehDepartment of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA.
Alice S WhittemoreDepartment of Health Research and Policy-Epidemiology, Stanford University School of Medicine, Stanford, CA, USA.
Linda S CookDivision of Epidemiology and Biostatistics, Department of Internal Medicine, University of New Mexico, Albuquerque, NM, USA.
Nhu D LeCancer Control Research, BC Cancer Agency, Vancouver, BC, Canada.
C Blake GilksPathology and Laboratory Medicine, University of British Columbia, Vancouver, BC, Canada.
Jacek GronwaldDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Anna JakubowskaDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Jan LubińskiDepartment of Genetics and Pathology, International Hereditary Cancer Center, Pomeranian Medical University, Szczecin, Poland.
Jan GawełkoMedical Faculty, Institute of Nursing and Health Sciences, University of Rzeszów, Rzeszów, Poland.
Honglin SongDepartment of Oncology and.
Jonathan P TyrerDepartment of Oncology and.
Nicolas WentzensenDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Louise BrintonDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Britton TrabertDivision of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, USA.
Jolanta LissowskaM. Sklodowska-Curie Memorial Cancer Center, Warsaw, Poland.
John R MclaughlinPublic Health Ontario, Toronto, ON, Canada.
Steven A NarodWomen's College Research Institute, University of Toronto, Toronto, ON, Canada.
Catherine PhelanDepartment of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL, USA.
Hoda Anton-CulverDepartment of Epidemiology and Center for Cancer Genetics Research & Prevention, School of Medicine, University of California Irvine, Irvine, CA, USA.
Argyrios ZiogasDepartment of Epidemiology and.
Diana EcclesFaculty of Medicine, University of Southampton, Southampton, UK.
Simon A GaytherDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Aleksandra Gentry-MaharajWomen's Cancer, Institute for Women's Health, University College London, London, UK.
Usha MenonWomen's Cancer, Institute for Women's Health, University College London, London, UK.
Susan J RamusDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Anna H WuDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA.
Agnieszka Dansonka-MieszkowskaDepartment of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Jolanta KupryjanczykDepartment of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Agnieszka TimorekDepartment of Obstetrics, Gynecology and Oncology, IInd Faculty of Medicine, Warsaw Medical University and Brodnowski Hospital, Warsaw, Poland.
Lukasz SzafronDepartment of Pathology and Laboratory Diagnostics, The Maria Sklodowska-Curie Memorial Cancer Center and Institute of Oncology, Warsaw, Poland.
Julie M CunninghamDivision of Experimental Pathology, Department of Laboratory Medicine and Pathology.
Brooke L FridleyDepartment of Biostatistics, University of Kansas, Kansas City, KS, USA.
Stacey J WinhamDivision of Biomedical Statistics and Informatics, Department of Health Sciences Research and.
Elisa V BanderaRutgers Cancer Institute of New Jersey, New Brunswick, NJ, USA.
Elizabeth M PooleDepartment of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Channing Division of Network Medicine, Department of Medicine and.
Terry K MorganDepartment of Pathology and Department of Obstetrics and Gynecology, OHSU, Portland, OR, USA.
Harvey A RischDepartment of Chronic Disease Epidemiology, Yale School of Public Health, New Haven, CT, USA.
Ellen L GoodeDivision of Epidemiology, Department of Health Science Research, Mayo Clinic, Rochester, MN, USA.
Joellen M SchildkrautDepartment of Community and Family Medicine and Cancer Control and Population Sciences, Duke Cancer Institute, Durham, NC, USA.
Penelope M WebbPopulation Health Department.
Celeste L PearceDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, CA, USA, Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, MI, USA and.
Andrew BerchuckDuke Cancer Institute, Duke University Medical Center, Durham, NC, USA.
Paul D P PharoahDepartment of Oncology and Department of Public Health and Primary Care, The Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
Grant W MontgomeryMolecular Epidemiology and.
Krina T ZondervanGenetic and Genomic Epidemiology Unit, Wellcome Trust Centre for Human Genetics and Endometriosis CaRe Centre, Nuffield Dept of Obstetrics & Gynaecology, University of Oxford, Oxford, UK.
Georgia Chenevix-TrenchGenetics and Computational Biology Department, QIMR Berghofer Medical Research Institute, 300 Herston Road, Herston, QLD 4006, Australia.
Stuart MacGregorStatistical Genetics, stuart.macgregor@qimrberghofer.edu.au.
University of Southern California · USBrigham and Women's Hospital · USCentre for Human Genetics · GBGerman Cancer Research Center · DENational Cancer Institute · USRadboud University Nijmegen · NLRoswell Park Comprehensive Cancer Center · USThe Maria Sklodowska-Curie National Research Institute of Oncology · PLUniversity of Helsinki · FIHaukeland University Hospital · NOInternational Hereditary Cancer Center · PLStanford University · USUniversitätsklinikum Erlangen · DEBC Cancer Agency · CACedars-Sinai Medical Center · USDartmouth College · USKU Leuven · BEMedizinische Hochschule Hannover · DEMemorial Sloan Kettering Cancer Center · USN.N. Alexandrov National Cancer Centre · BY

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
USC/NORRIS COMPREHENSIVE CANCER CENTER (CORE) SUPPORTP30CA014089 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI Fumito Ito · 1985 to 2026
$181.4M
Women's Cancer ProgramP30CA015083 · NCI · MAYO CLINIC ROCHESTER · PI Felicity Enders · 1985 to 2026
$151.3M
Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI MARK G FRATTINI · 1985 to 2026
$116.6M
Hormone-Related CancersZIACP010126 · NCI · DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS · PI GIERACH, GRETCHEN · 2009 to 2025
$103.5M
TRANSCRIPTIONAL PROFILINGP30CA072720 · NCI · UNIV OF MED/DENT NJ-R W JOHNSON MED SCH · PI Chang S Chan · 1997 to 2026
$94.5M
TRANSLATIONAL RESEARCHP30CA076292 · NCI · UNIVERSITY OF SOUTH FLORIDA · PI KENNETH Lynn WRIGHT · 1998 to 2026
$93.5M
University of Pittsburgh Clinical and Translational Science InstituteUL1TR000005 · NCATS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI REIS, STEVEN E · 2012 to 2015
$50.8M
Use of microfluidic tumor cultures to enable clinical trials of therapies for ovarian cancerP50CA136393 · NCI · MAYO CLINIC ROCHESTER · PI Zhenkun Lou · 2009 to 2026
$37.0M
Risk Factors for Breast Cancer in Younger NursesR01CA050385 · NCI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI ELIASSEN, A. HEATHER, WILLETT, WALTER C. · 1989 to 2019
$32.3M
WITHIN SUBJ VARIABILITY IN MEASUREMENTS DRUG METABOL ENZYMES IN HLTY SUBJM01RR000056 · NCRR · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI LEVINE, ARTHUR S · 1985 to 2006
$29.2M
Northern California Cooperative Family Registry for Breast CancerU01CA069417 · NCI · NORTHERN CALIFORNIA CANCER CENTER · PI JOHN, ESTHER M. · 1995 to 2010
$22.4M
Cancer Research UK 10124Cancer Research UK 16561CIHR MOP-86727NCATS NIH HHS UL1 TR000005NCI NIH HHS K07 CA080668NCI NIH HHS K07 CA092044NCI NIH HHS K07 CA095666NCI NIH HHS K07-CA095666NCI NIH HHS K07 CA143047NCI NIH HHS K07-CA143047NCI NIH HHS K07-CA80668NCI NIH HHS K22 CA138563NCI NIH HHS K22-CA138563NCI NIH HHS N01 CN025403NCI NIH HHS N01-CN55424NCI NIH HHS N01 PC035137NCI NIH HHS N01-PC035137NCI NIH HHS N01 PC067010NCI NIH HHS N01-PC067010NCI NIH HHS N01-PC67001NCI NIH HHS P01 CA017054NCI NIH HHS P01-CA017054NCI NIH HHS P01-CA087696NCI NIH HHS P30 CA008748NCI NIH HHS P30-CA008748NCI NIH HHS P30 CA014089NCI NIH HHS P30 CA015083NCI NIH HHS P30 CA016056NCI NIH HHS P30 CA072720NCI NIH HHS P30-CA072720NCI NIH HHS P30 CA076292NCI NIH HHS P30-CA15083NCI NIH HHS P50 CA105009NCI NIH HHS P50-CA105009NCI NIH HHS P50 CA136393NCI NIH HHS P50-CA136393NCI NIH HHS P50 CA159981NCI NIH HHS P50-CA159981NCI NIH HHS R01-CA014089NCI NIH HHS R01-CA016056NCI NIH HHS R01-CA017054NCI NIH HHS R01 CA049449NCI NIH HHS R01-CA049449NCI NIH HHS R01 CA050385NCI NIH HHS R01-CA050385NCI NIH HHS R01 CA054419NCI NIH HHS R01-CA054419NCI NIH HHS R01 CA058598NCI NIH HHS R01-CA058598NCI NIH HHS R01 CA058860NCI NIH HHS R01-CA058860NCI NIH HHS R01-CA061107NCI NIH HHS R01-CA061132NCI NIH HHS R01 CA063678NCI NIH HHS R01-CA063678NCI NIH HHS R01 CA063682NCI NIH HHS R01-CA063682NCI NIH HHS R01 CA067262NCI NIH HHS R01-CA067262NCI NIH HHS R01-CA071766NCI NIH HHS R01 CA074850NCI NIH HHS R01-CA074850NCI NIH HHS R01-CA080978NCI NIH HHS R01 CA083918NCI NIH HHS R01-CA083918NCI NIH HHS R01 CA087538NCI NIH HHS R01-CA087538NCI NIH HHS R01 CA087696NCI NIH HHS R01-CA092044NCI NIH HHS R01 CA095023NCI NIH HHS R01-CA095023NCI NIH HHS R01 CA112523NCI NIH HHS R01-CA112523NCI NIH HHS R01 CA114343NCI NIH HHS R01-CA114343NCI NIH HHS R01 CA122443NCI NIH HHS R01-CA122443NCI NIH HHS R01 CA126841NCI NIH HHS R01-CA126841NCI NIH HHS R01 CA136924NCI NIH HHS R01-CA136924NCI NIH HHS R01 CA149429NCI NIH HHS R01-CA149429NCI NIH HHS R03 CA113148NCI NIH HHS R03-CA113148NCI NIH HHS R03 CA115195NCI NIH HHS R03-CA115195NCI NIH HHS U01 CA069417NCI NIH HHS U01-CA069417NCI NIH HHS U01-CA071966NCI NIH HHS U19 CA148112NCI NIH HHS UM1-CA176726NCI NIH HHS UM1-CA186107NCRR NIH HHS M01 RR000056NCRR NIH HHS MO1-RR000056Wellcome Trust 076113Wellcome Trust 084766Wellcome Trust 085235Wellcome Trust 085475Wellcome Trust WT084766/Z/08/ZWellcome Trust WT085235/Z/08/ZWellcome Trust WT098017
6 · The paper itself

Abstract

Epidemiological studies have demonstrated associations between endometriosis and certain histotypes of ovarian cancer, including clear cell, low-grade serous and endometrioid carcinomas. We aimed to determine whether the observed associations might be due to shared genetic aetiology. To address this, we used two endometriosis datasets genotyped on common arrays with full-genome coverage (3194 cases and 7060 controls) and a large ovarian cancer dataset genotyped on the customized Illumina Infinium iSelect (iCOGS) arrays (10 065 cases and 21 663 controls). Previous work has suggested that a large number of genetic variants contribute to endometriosis and ovarian cancer (all histotypes combined) susceptibility. Here, using the iCOGS data, we confirmed polygenic architecture for most histotypes of ovarian cancer. This led us to evaluate if the polygenic effects are shared across diseases. We found evidence for shared genetic risks between endometriosis and all histotypes of ovarian cancer, except for the intestinal mucinous type. Clear cell carcinoma showed the strongest genetic correlation with endometriosis (0.51, 95% CI = 0.18-0.84). Endometrioid and low-grade serous carcinomas had similar correlation coefficients (0.48, 95% CI = 0.07-0.89 and 0.40, 95% CI = 0.05-0.75, respectively). High-grade serous carcinoma, which often arises from the fallopian tubes, showed a weaker genetic correlation with endometriosis (0.25, 95% CI = 0.11-0.39), despite the absence of a known epidemiological association. These results suggest that the epidemiological association between endometriosis and ovarian adenocarcinoma may be attributable to shared genetic susceptibility loci.

Indexed as

Polymorphism, Single NucleotideEndometriosisFemaleGenetic Association StudiesGenetic Predisposition to DiseaseHumansOligonucleotide Array Sequence AnalysisOvarian NeoplasmsRisk

Identifiers

PMID26231222
PMCPMC4581608
OpenAlexW1885849841

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.