ArticleThe Journal of biological chemistry2015
C1q protein binds to the apoptotic nucleolus and causes C1 protease degradation of nucleolar proteins.
Article in The Journal of biological chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Editorial: Expert opinions and perspectives in complement: 2022.Frontiers in immunology · 2023Article
- The axis of complement C1 and nucleolus in antinuclear autoimmunity.Frontiers in immunology · 2023Review
- Autoantibodies against Complement Classical Pathway Components C1q, C1r, C1s and C1-Inh in Patients with Lupus Nephritis.International journal of molecular sciences · 2022Article
- Complement C1s as a diagnostic marker and therapeutic target: Progress and propective.Frontiers in immunology · 2022Review
- Neutrophil heterogeneity in complement C1q expression associated with sepsis mortality.Frontiers in immunology · 2022Article
- The GAR/RGG motif defines a family of nuclear alarmins.Cell death & disease · 2021Article
- The Immunopathology of Complement Proteins and Innate Immunity in Autoimmune Disease.Clinical reviews in allergy & immunology · 2020Review
- Tumour-cell-derived complement components C1r and C1s promote growth of cutaneous squamous cell carcinoma.The British journal of dermatology · 2020Article
- Editorial: C1q: A Molecular Bridge to Innate and Adaptive Immunity.Frontiers in immunology · 2020Article
- C1r/C1s deficiency is insufficient to induce murine systemic lupus erythematosus.Genes and immunity · 2019Article
- Article
- The linker histone H1.2 is a novel component of the nucleolar organizer regions.The Journal of biological chemistry · 2018Article
- Human and Murine Evidence for Mechanisms Driving Autoimmune Photosensitivity.Frontiers in immunology · 2018Review
- The immune response to secondary necrotic cells.Apoptosis : an international journal on programmed cell death · 2017Review
- C1 Complex: An Adaptable Proteolytic Module for Complement and Non-Complement Functions.Frontiers in immunology · 2017Review
- Complement the cell death.Cell death & disease · 2016Article
- Cutaneous lupus erythematosus: updates on pathogenesis and associations with systemic lupus.Current opinion in rheumatology · 2016Review
- Proteolytic inactivation of nuclear alarmin high-mobility group box 1 by complement protease C1s during apoptosis.Cell death discovery · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In infection, complement C1q recognizes pathogen-congregated antibodies and elicits complement activation. Among endogenous ligands, C1q binds to DNA and apoptotic cells, but whether C1q binds to nuclear DNA in apoptotic cells remains to be investigated. With UV irradiation-induced apoptosis, C1q initially bound to peripheral cellular regions in early apoptotic cells. By 6 h, binding concentrated in the nuclei to the nucleolus but not the chromatins. When nucleoli were isolated from non-apoptotic cells, C1q also bound to these structures. In vivo, C1q exists as the C1 complex (C1qC1r2C1s2), and C1q binding to ligands activates the C1r/C1s proteases. Incubation of nucleoli with C1 caused degradation of the nucleolar proteins nucleolin and nucleophosmin 1. This was inhibited by the C1 inhibitor. The nucleoli are abundant with autoantigens. C1q binding and C1r/C1s degradation of nucleolar antigens during cell apoptosis potentially reduces autoimmunity. These findings help us to understand why genetic C1q and C1r/C1s deficiencies cause systemic lupus erythematosus.
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