ArticlePloS one2015
Secretor Status Is Strongly Associated with Microbial Alterations Observed during Pregnancy.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Effects of maternal allergy and supplementation with ω-3 fatty acid and probiotic on human milk oligosaccharides.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2025Trial
- Association of human milk oligosaccharides and nutritional status of young infants among Bangladeshi mother-infant dyads.Scientific reports · 2022Trial
- Association among Gestational Weight Gain, Fucosylated Human Milk Oligosaccharides, and Breast Milk Microbiota─An Evidence in Healthy Mothers from Northwest China.Journal of agricultural and food chemistry · 2024Article
- Necrotizing Enterocolitis: The Role of Hypoxia, Gut Microbiome, and Microbial Metabolites.International journal of molecular sciences · 2023Review
- Maternal H-antigen secretor status is an early biomarker for potential preterm delivery.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- TheFrontiers in cellular and infection microbiology · 2021Article
- Maternal diet alters human milk oligosaccharide composition with implications for the milk metagenome.Scientific reports · 2020Article
- Blood type and the microbiome- untangling a complex relationship with lessons from pathogens.Current opinion in microbiology · 2020Review
- The Interactions between Host Glycobiology, Bacterial Microbiota, and Viruses in the Gut.Viruses · 2018Review
- A cross-sectional comparative study of gut bacterial community of Indian and Finnish children.Scientific reports · 2017Article
- Relevance of secretor status genotype and microbiota composition in susceptibility to rotavirus and norovirus infections in humans.Scientific reports · 2017Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
During pregnancy there are significant changes in gut microbiota composition and activity. The impact of secretor status as determined by genotyping FUT2 (fucosyltransferase 2) gene was taken as one of the confounding factors associated with faecal microbiota changes during pregnancy. In this prospective study, we followed women during pregnancy (total = 123 of which secretors = 108, non-secretors = 15) and characterised their gut microbiota by quantitative polymerase chain reaction (qPCR), Fluorescence In situ Hybridisation (FISH), Denaturing Gradient Gel Electrophoresis (DGGE) and pyrosequencing. qPCR revealed that C. coccoides group counts decreased significantly in non-secretors in comparison to secretors (p = 0.02). Similar tendency was found by FISH analysis in Clostridium histolyticum and Lactobacillus-Enterococcus groups between the secretor and the non-secretor pregnant women. DGGE analysis showed significant decrease in richness of Clostridium sp. between secretor and non-secretor mothers during pregnancy. Pyrosequencing based analysis at phyla level showed that there is greater increase in Actinobacteria in secretors in comparison to non-secretors, whereas Proteobacteria showed more increase in non-secretors. Change in relative abundance of Clostridiaceae family from first to third trimester were significantly associated with secretor status of pregnant women (p = 0.05). Polyphasic approach for microbiota analysis points out that the host secretor status (FUT2 genotype) affects the gut microbiota during pregnancy. This may lead to altered infant gut microbiota colonization.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.