ArticlePloS one2015
In Vivo Voltage-Sensitive Dye Study of Lateral Spreading of Cortical Activity in Mouse Primary Visual Cortex Induced by a Current Impulse.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 45 citations in OpenAlex.
- Psychedelic 5-HT2A agonist increases spontaneous and evoked 5-Hz oscillations in visual and retrosplenial cortex.Communications biology · 2026Article
- Spatio-temporal activation patterns of neuronal population evoked by optostimulation and the comparison to electrical microstimulation.Scientific reports · 2023Article
- Optogenetic stimulation of the primary visual cortex drives activity in the visual association cortex.Current research in neurobiology · 2023Article
- Micro-magnetic stimulation of primary visual cortex induces focal and sustained activation of secondary visual cortex.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2022Article
- Autonomic dysfunction in epilepsy mouse models with implications for SUDEP research.Frontiers in neurology · 2022Review
- Multichannel stimulation module as a tool for animal studies on cortical neural prostheses.Frontiers in medical technology · 2022Article
- In silico voltage-sensitive dye imaging reveals the emergent dynamics of cortical populations.Nature communications · 2021Article
- Spatially confined responses of mouse visual cortex to intracortical magnetic stimulation from micro-coils.Journal of neural engineering · 2020Article
- Micro-Coil Design Influences the Spatial Extent of Responses to Intracortical Magnetic Stimulation.IEEE transactions on bio-medical engineering · 2019Article
- Widespread activation of awake mouse cortex by electrical stimulation.International IEEE/EMBS Conference on Neural Engineering : [proceedings]. International IEEE EMBS Conference on Neural Engineering · 2019Article
- Spatio-temporal characteristics of population responses evoked by microstimulation in the barrel cortex.Scientific reports · 2018Article
- Classification of Spatiotemporal Neural Activity Patterns in Brain Imaging Data.Scientific reports · 2018Article
- Long-Range, Border-Crossing, Horizontal Axon Radiations Are a Common Feature of Rat Neocortical Regions That Differ in Cytoarchitecture.Frontiers in neuroanatomy · 2018Article
- Age-related changes in the spatiotemporal responses to electrical stimulation in the visual cortex of rats with progressive vision loss.Scientific reports · 2017Article
- Prediction of the Seizure Suppression Effect by Electrical Stimulation via a Computational Modeling Approach.Frontiers in computational neuroscience · 2017Article
- Inhibition of Mammalian Target of Rapamycin (mTOR) Signaling in the Insular Cortex Alleviates Neuropathic Pain after Peripheral Nerve Injury.Frontiers in molecular neuroscience · 2017Article
- Population Response Propagation to Extrastriate Areas Evoked by Intracortical Electrical Stimulation in V1.Frontiers in neural circuits · 2016Article
- Neural mechanisms of the temporal response of cortical neurons to intracortical microstimulation.Brain stimulationArticle
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the mammalian primary visual cortex (V1), lateral spreading of excitatory potentials is believed to be involved in spatial integrative functions, but the underlying cortical mechanism is not well understood. Visually-evoked population-level responses have been shown to propagate beyond the V1 initial activation site in mouse, similar to higher mammals. Visually-evoked responses are, however, affected by neuronal circuits prior to V1 (retina, LGN), making the separate analysis of V1 difficult. Intracortical stimulation eliminates these initial processing steps. We used in vivo RH1691 voltage-sensitive dye (VSD) imaging and intracortical microstimulation in adult C57BL/6 mice to elucidate the spatiotemporal properties of population-level signal spreading in V1 cortical circuits. The evoked response was qualitatively similar to that measured in single-cell electrophysiological experiments in rodents: a fast transient fluorescence peak followed by a fast and a slow decrease or hyperpolarization, similar to EPSP and fast and slow IPSPs in single cells. The early cortical response expanded at speeds commensurate with long horizontal projections (at 5% of the peak maximum, 0.08-0.15 m/s) however, the bulk of the VSD signal propagated slowly (at half-peak maximum, 0.05-0.08 m/s) suggesting an important role of regenerative multisynaptic transmission through short horizontal connections in V1 spatial integrative functions. We also found a tendency for a widespread and fast cortical response suppression in V1, which was eliminated by GABAA-antagonists gabazine and bicuculline methiodide. Our results help understand the neuronal circuitry involved in lateral spreading in V1.
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