ArticlePloS one2015
Effect of Twice-Daily Blue Light Treatment on Matrix-Rich Biofilm Development.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 78 citations in OpenAlex.
- A randomized controlled trial of home-applied dual-light photodynamic therapy during supportive periodontal care (HOPE-CP study).Journal of periodontology · 2026Trial
- Effects of blue-light LED toothbrush on reducing dental plaque and gingival inflammation in orthodontic patients with fixed appliances: a crossover randomized controlled trial.BMC oral health · 2023Trial
- Article
- Anti-Cariogenic Effect of Trans-Cinnamaldehyde in an In Vitro Mouse Jaw Explant Model.Pharmaceuticals (Basel, Switzerland) · 2026Article
- Effect of 6-Shogaol Derived from Ginger (Nutrients · 2025Article
- A Collection and Analysis of Simplified Data for a Better Understanding of the Complex Process of Biofilm Inactivation by Ultraviolet and Visible Irradiation.Microorganisms · 2025Review
- A Standardized Mouse Model for Wound Infection withInternational journal of molecular sciences · 2024Article
- Biofilm formation and manipulation with optical tweezers.Biomedical optics express · 2024Article
- Trans-Cinnamaldehyde-FightingPharmaceutics · 2024Article
- The Evolving Microbiome of Dental Caries.Microorganisms · 2024Review
- The power of light - From dental materials processing to diagnostics and therapeutics.Biomaterial investigations in dentistry · 2024Review
- Antibacterial and Antiviral Properties ofFoods (Basel, Switzerland) · 2023Article
- Photobiomodulation with Blue Light on Wound Healing: A Scoping Review.Life (Basel, Switzerland) · 2023Article
- Home-Applied Dual-Light Photodynamic Therapy in the Treatment of Stable Chronic Periodontitis (HOPE-CP)-Three-Month Interim Results.Dentistry journal · 2022Article
- Repeated Home-Applied Dual-Light Antibacterial Photodynamic Therapy Can Reduce Plaque Burden, Inflammation, and aMMP-8 in Peri-Implant Disease-A Pilot Study.Current issues in molecular biology · 2022Article
- Genetic Factors Affect the Survival and Behaviors of Selected Bacteria during Antimicrobial Blue Light Treatment.International journal of molecular sciences · 2021Review
- Anti-Biofilm Activity of Cannabigerol againstMicroorganisms · 2021Article
- Anti-Bacterial Properties of Cannabigerol TowardFrontiers in microbiology · 2021Article
- Understanding building-occupant-microbiome interactions toward healthy built environments: A review.Frontiers of environmental science & engineering · 2021Review
- Building upon current knowledge and techniques of indoor microbiology to construct the next era of theory into microorganisms, health, and the built environment.Journal of exposure science & environmental epidemiology · 2020Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe use of blue light has been proposed as a direct means of affecting local bacterial infections, however the use of blue light without a photosensitizer to prevent the biofilm development has not yet been explored. The aim of this study was to determine how the twice-daily treatment with blue light affects the development and composition of a matrix-rich biofilm. METHODOLOGY/PRINCIPAL
findingsBiofilms of Streptococcus mutans UA159 were formed on saliva-coated hydroxyapatite discs for 5 days. The biofilms were exposed twice-daily to non-coherent blue light (LumaCare; 420 nm) without a photosensitizer. The distance between the light and the sample was 1.0 cm; energy density of 72 J cm-2; and exposure time of 12 min 56 s. Positive and negative controls were twice-daily 0.12% chlorhexidine (CHX) and 0.89% NaCl, respectively. Biofilms were analyzed for bacterial viability, dry-weight, and extra (EPS-insoluble and soluble) and intracellular (IPS) polysaccharides. Variable pressure scanning electron microscopy and confocal scanning laser microscopy were used to check biofilm morphology and bacterial viability, respectively. When biofilms were exposed to twice-daily blue light, EPS-insoluble was reduced significantly more than in either control group (CHX and 0.89% NaCl). Bacterial viability and dry weight were also reduced relative to the negative control (0.89% NaCl) when the biofilms were treated with twice-daily blue light. Different morphology was also visible when the biofilms were treated with blue light.
conclusionsTwice-daily treatment with blue light without a photosensitizer is a promising mechanism for the inhibition of matrix-rich biofilm development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.