Evidence map›Paper›PMID 26230196›Full record

ArticleKidney international2015

Inflammation and hypoxia in the kidney: friends or foes?

Volker H Haase

Open access · bronzeAbstract readComment
In one paragraph

Article in Kidney international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Observational
  8. Article
  9. Review
  10. Article
  11. Signalling pathways involved in hypoxia-induced renal fibrosis.Journal of cellular and molecular medicine · 2017
    Review
  12. Hypoxia, HIF, and Associated Signaling Networks in Chronic Kidney Disease.International journal of molecular sciences · 2017
    Review
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Volker H Haase1] Division of Nephrology and Hypertension, Departments of Medicine, Cancer Biology, and Molecular Physiology and Biophysics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA [2] Medical and Research Services, Department of Veterans Affairs Hospital, Tennessee Valley Healthcare System, Nashville, Tennessee, USA.
Vanderbilt University · US

Funding

Molecular Mechanisms of Renal InjuryR01DK081646 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAASE, VOLKER HANS · 2008 to 2021
$4.3M
Metabolic Reprogramming in Acute Kidney InjuryR01DK101791 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HAASE, VOLKER HANS · 2014 to 2018
$1.8M
Hypoxia-Inducible Factors in Liver MetabolismR01DK080821 · NIDDK · VANDERBILT UNIVERSITY · PI HAASE, VOLKER HANS · 2009 to 2013
$1.7M
Cellular and Molecular Mechanisms of Renal AnemiaI01BX002348 · VA · VETERANS HEALTH ADMINISTRATION · PI Volker Hans Haase · 2014 to 2026
–
BLRD VA I01 BX002348NIDDK NIH HHS R01 DK080821NIDDK NIH HHS R01-DK080821NIDDK NIH HHS R01 DK081646NIDDK NIH HHS R01-DK081646NIDDK NIH HHS R01 DK101791NIDDK NIH HHS R01-DK101791
6 · The paper itself

Abstract

Hypoxic injury is commonly associated with inflammatory-cell infiltration, and inflammation frequently leads to the activation of cellular hypoxia response pathways. The molecular mechanisms underlying this cross-talk during kidney injury are incompletely understood. Yamaguchi and colleagues identify CCAAT/enhancer-binding protein δ as a cytokine- and hypoxia-regulated transcription factor that fine-tunes hypoxia-inducible factor-1 signaling in renal epithelial cells and thus provide a novel molecular link between hypoxia and inflammation in kidney injury.

Indexed as

Gene Expression RegulationAnimalsCCAAT-Enhancer-Binding Protein-deltaHumansHypoxiaHypoxia-Inducible Factor 1, alpha SubunitKidneyMaleNephritisCCAAT-Enhancer-Binding Protein-deltaHypoxia-Inducible Factor 1, alpha Subunit

Identifiers

PMID26230196
PMCPMC4534718
OpenAlexW2212627680

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.