ArticlePloS one2015
Cardiac Dysregulation and Myocardial Injury in a 6-Hydroxydopamine-Induced Rat Model of Sympathetic Denervation.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 32 citations in OpenAlex.
- Development and modeling of cardiac autonomic innervation.Nature cardiovascular research · 2025Review
- Mice Models for Peripheral Denervation to Enhance Vascular Regeneration.Tissue engineering. Part C, Methods · 2025Article
- Therapeutic Approaches to Non-Motor Symptoms of Parkinson's Disease: A Current Update on Preclinical Evidence.Current neuropharmacology · 2023Article
- Spinal cord injury impairs cardiac function due to impaired bulbospinal sympathetic control.Nature communications · 2022Article
- The progress of pulmonary artery denervation.Cardiology journal · 2022Review
- Neuregulin-1, in a Conducive Milieu with Wnt/BMP/Retinoic Acid, Prolongs the Epicardial-Mediated Cardiac Regeneration Capacity of Neonatal Heart Explants.Journal of stem cells & regenerative medicine · 2021Article
- Device-Based Sympathetic Nerve Regulation for Cardiovascular Diseases.Frontiers in cardiovascular medicine · 2021Review
- Effects of sympathectomy on myocardium remodeling and function.Clinics (Sao Paulo, Brazil) · 2021Article
- Reduced genioglossus muscle activity caused by fluid overload in anesthetized rats.Physiological reports · 2020Article
- Guizhi Decoction () Inhibits Cholinergic Transdifferentiation by Regulating Imbalance of NGF and LIF in Salt-Sensitive Hypertensive Heart Failure Rats.Chinese journal of integrative medicine · 2020Article
- Xiao-Qing-Long-Tang Maintains Cardiac Function during Heart Failure with Reduced Ejection Fraction in Salt-Sensitive Rats by Regulating the Imbalance of Cardiac Sympathetic Innervation.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Echocardiographic Epicardial Adipose Tissue Thickness for Risk Stratification of Patients With Heart Failure.Frontiers in physiology · 2020Article
- Autonomic dysfunction in Parkinson disease and animal models.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2019Review
- Local sympathetic denervation attenuates myocardial inflammation and improves cardiac function after myocardial infarction in mice.Cardiovascular research · 2018Article
- Article
- Adrenergic regulation during acute hepatic infection with Entamoeba histolytica in the hamster: involvement of oxidative stress, Nrf2 and NF-KappaB.Parasite (Paris, France) · 2017Article
- Part and Parcel of the Cardiac Autonomic Nerve System: Unravelling Its Cellular Building Blocks during Development.Journal of cardiovascular development and disease · 2016Review
- Sympathetic Reinnervation Is Required for Mammalian Cardiac Regeneration.Circulation research · 2015Article
- The Nervous Heart: Role of Sympathetic Reinnervation in Cardiac Regeneration.Circulation research · 2015Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiac sympathetic denervation is found in various cardiac pathologies; however, its relationship with myocardial injury has not been thoroughly investigated.
methodsTwenty-four rats were assigned to the normal control group (NC), sympathectomy control group (SC), and a sympathectomy plus mecobalamin group (SM). Sympathectomy was induced by injection of 6-OHDA, after which, the destruction and distribution of sympathetic and vagal nerve in the left ventricle (LV) myocardial tissue were determined by immunofluorescence and ELISA. Heart rate variability (HRV), ECG and echocardiography, and assays for myocardial enzymes in serum before and after sympathectomy were examined. Morphologic changes in the LV by HE staining and transmission electron microscope were used to estimate levels of myocardial injury and concentrations of inflammatory cytokines were used to reflect the inflammatory reaction.
resultsInjection of 6-OHDA decreased NE (933.1 ± 179 ng/L for SC vs. 3418.1± 443.6 ng/L for NC, P < 0.01) and increased NGF (479.4± 56.5 ng/mL for SC vs. 315.85 ± 28.6 ng/mL for NC, P < 0.01) concentrations. TH expression was reduced, while ChAT expression showed no change. Sympathectomy caused decreased HRV and abnormal ECG and echocardiography results, and histopathologic examinations showed myocardial injury and increased collagen deposition as well as inflammatory cell infiltration in the cardiac tissue of rats in the SC and SM groups. However, all pathologic changes in the SM group were less severe compared to those in the SC group.
conclusionsChemical sympathectomy with administration of 6-OHDA caused dysregulation of the cardiac autonomic nervous system and myocardial injuries. Mecobalamin alleviated inflammatory and myocardial damage by protecting myocardial sympathetic nerves.
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