Evidence map›Paper›PMID 26229984›Full record

ArticleScience advances2015

Transplantability of a circadian clock to a noncircadian organism.

Anna H Chen, David Lubkowicz, Vivian Yeong, Roger L Chang, Pamela A Silver

Open access · goldAbstract read
In one paragraph

Article in Science advances, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 36 citations in OpenAlex.

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  5. International journal of molecular sciences · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Anna H ChenDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA ; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA.
David LubkowiczDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA ; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA.
Vivian YeongDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA ; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA.
Roger L ChangDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA ; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA.
Pamela A SilverDepartment of Systems Biology, Harvard Medical School, Boston, MA 02115, USA ; Wyss Institute for Biologically Inspired Engineering, Harvard Medical School, Boston, MA 02115, USA.
Center for Systems Biology · USHarvard University · US

Funding

Harvard Systems Biology Graduate ProgramT32GM080177 · NIGMS · HARVARD UNIVERSITY · PI MITCHISON, TIMOTHY J, MURRAY, ANDREW W · 2010 to 2019
$2.8M
NIGMS NIH HHS T32 GM080177
6 · The paper itself

Abstract

Circadian oscillators are posttranslationally regulated and affect gene expression in autotrophic cyanobacteria. Oscillations are controlled by phosphorylation of the KaiC protein, which is modulated by the KaiA and KaiB proteins. However, it remains unclear how time information is transmitted to transcriptional output. We show reconstruction of the KaiABC oscillator in the noncircadian bacterium

Indexed as

Circadian ClocksEscherichia coliBacterial ProteinsCircadian RhythmCircadian Rhythm Signaling Peptides and ProteinsCyanobacteriaGene Expression Regulation, BacterialPhosphorylationPromoter Regions, GeneticTranscription, GeneticBacterial ProteinsCircadian Rhythm Signaling Peptides and ProteinsKaiA protein, cyanobacteriaKaiB protein, cyanobacteriaKaiC protein, cyanobacteria

Identifiers

PMID26229984
PMCPMC4517858
OpenAlexW2142468578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.