ArticleRevista brasileira de ortopedia
Profile of collagen gene expression in the glenohumeral capsule of patients with traumatic anterior instability of the shoulder.
Article in Revista brasileira de ortopedia. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Transcriptomics of Anterior Shoulder Instability: Differences in Gene Expression in the Blood of Patients With and Without Significant Glenoid Bone Loss.Orthopaedic journal of sports medicine · 2025Article
- [Research progress on pathological changes of glenohumeral capsule in patients with recurrent shoulder anterior dislocation].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2025Review
- Genetic Polymorphisms inRevista brasileira de ortopedia · 2023Article
- Genetic Aspects in Shoulder Disorders.Revista brasileira de ortopedia · 2020Article
- The Epidemiology and Natural History of Anterior Shoulder Instability.Current reviews in musculoskeletal medicine · 2017Review
- The roles of Tenascin C and Fibronectin 1 in adhesive capsulitis: a pilot gene expression study.Clinics (Sao Paulo, Brazil) · 2016Article
- Analysis of postoperative monitoring of patients undergoing shoulder arthroscopy for anterior instability.Revista brasileira de ortopediaArticle
- Biomarkers of Injury Severity in Shoulder Instability and Posttraumatic Osteoarthritis.JB & JS open accessReview
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6 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the expression of the genes COL1A1, COL1A2, COL3A1 and COL5A1 in the glenohumeral capsule of patients with traumatic anterior instability of the shoulder.
methodsSamples from the glenohumeral capsule of 18 patients with traumatic anterior instability of the shoulder were evaluated. Male patients with a positive grip test and a Bankart lesion seen on magnetic resonance imaging were included. All the patients had suffered more than one episode of shoulder dislocation. Samples were collected from the injured glenohumeral capsule (anteroinferior region) and from the macroscopically unaffected region (anterosuperior region) of each patient. The expression of collagen genes was evaluated using the polymerase chain reaction after reverse transcription with quantitative analysis (qRT-PCR).
resultsThe expression of COL1A1, COL1A2 and COL3A1 did not differ between the two regions of the shoulder capsule. However, it was observed that the expression of COL5A1 was significantly lower in the anteroinferior region than in the anterosuperior region (median ± interquartile range: 0.057 ± 0.052 vs. 0.155 ± 0.398; p = 0.028) of the glenohumeral capsule.
conclusionThe affected region of the glenohumeral capsule in patients with shoulder instability presented reduced expression of COL5A1.
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