ArticleAnnals of medical and health sciences research
Expression of Podoplanin in Different Grades of Oral Squamous Cell Carcinoma.
Article in Annals of medical and health sciences research. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Diagnostic Value of Serum and Salivary Podoplanin as Clinical Biomarkers for Distinguishing Oral Cancer from Oral Leukoplakia.Diagnostics (Basel, Switzerland) · 2026Article
- Podoplanin expression in various types of oral dysplasia and oral squamous cell carcinoma.Journal of Taibah University Medical Sciences · 2025Article
- Article
- Study of Podoplanin Expression in Head and Neck Squamous Cell Carcinoma.Iranian journal of pathology · 2022Article
- Prognostic Potential of the Expression of Podoplanin (D2-40) Within Cells of Squamous Cell Carcinoma of the Larynx and Hypopharynx.World journal of oncology · 2020Article
- Association of the co-expression of SOX2 and Podoplanin in the progression of oral squamous cell carcinomas - an immunohistochemical study.Journal of applied oral science : revista FOB · 2019Article
- Double-staining of E-cadherin and podoplanin offer help in the pathological diagnosis of indecisive early-invasive oral squamous cell carcinoma.International journal of clinical and experimental pathology · 2018Article
- Podoplanin expression in oral potentially malignant disorders and oral squamous cell carcinoma.Journal of clinical and experimental dentistry · 2017Article
- Prognostic value of PAX9 in patients with esophageal squamous cell carcinoma and its prediction value to radiation sensitivity.Molecular medicine reports · 2017Article
- Expression of Podoplanin in Laryngeal Squamous Cell Carcinoma and Dysplasia.Journal of clinical and diagnostic research : JCDR · 2017Article
- Immunohistochemical evaluation of D2-40, Galectin-3, Maspin and MCM7 expression in palate squamous cell carcinomas.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
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5 authors.
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Abstract
backgroundThe expression of podoplanin is up-regulated in a number of different human cancers, including squamous cell carcinoma of the oral cavity and its relationship with tumor invasion raises the possibility that podoplanin expression could be used as a biomarker for diagnosis and prognosis.
aimThe aim of the present study is to evaluate the expression of podoplanin in different grades of squamous cell carcinoma (SCC) and to correlate the expression of podoplanin with relevant clinical features such as age, sex, site and associated habits. MATERIALS AND
methodsRetrospective study was carried on formalin fixed, paraffin embedded blocks of oral SCC (OSCC) from the archives of Department of Oral and Maxillofacial Pathology, Vishnu Dental College, Bhimavaram. Thirty diagnosed cases were included, of which 10 were well-differentiated SCC (WDSCC) (n = 10), 10 moderately DSCC and 10 poorly DSCC. Demographics including age, sex, gender and associated habit history, were recorded. Immunohistochemical staining was done with podoplanin anti D2-40 antibody, for all the cases of OSCC and assessed qualitatively. The data obtained were tabulated and subjected to statistical analysis.
resultsIn the present study, 27 cases of SCC showed podoplanin expression and remaining three cases showed no expression. The scoring criterion suggested by Yuan et al. was followed for semi-quantitative assessment. OSCC, seven cases presented weak expression (Immunoreactive score [IRS] 0-3), 15 presented moderate expression (IRS Score 4-7) and 5 presented high expression (IRS Score > 8). The assessment of podoplanin expression in the cytoplasm, the membrane and the cytoplasm and membrane (both) of tumor cells showed overall high positivity in the cytoplasmic followed by both and the membrane.
conclusionPodoplanin could be a potent biomarker in assessing the cytoplasm/membrane staining of tumor cells. Furthermore, a high level of podoplanin expression is suggestive of high frequency of lymph node metastasis and immature status in the differentiation process of OSCC.
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