Evidence map›Paper›PMID 26229523›Full record

ArticleMetabolomics : Official journal of the Metabolomic Society2013

High-performance metabolic profiling with dual chromatography-Fourier-transform mass spectrometry (DC-FTMS) for study of the exposome.

Quinlyn A Soltow, Frederick H Strobel, Keith G Mansfield, Lynn Wachtman, Youngja Park, Dean P Jones

Abstract read
In one paragraph

Article in Metabolomics : Official journal of the Metabolomic Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 149 papers.

0numbers the graph read from it
0cells of the map it votes in
149citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

149 citing papers in PubMed.

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  6. Metabolomics of Aerobic Exercise in Chronic Stroke Survivors: A Pilot Study.Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2019
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89 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Quinlyn A SoltowDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, Emory University, Atlanta, GA 30322, USA.
Frederick H StrobelMass Spectrometry Center, Emory University, Atlanta, GA 30322, USA.
Keith G MansfieldHarvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA.
Lynn WachtmanHarvard Medical School, New England Primate Research Center, Southborough, MA 01772, USA.
Youngja ParkDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, Emory University, Atlanta, GA 30322, USA.
Dean P JonesDepartment of Medicine, Division of Pulmonary, Allergy and Critical Care, Emory University, Atlanta, GA 30322, USA.

Funding

ZETA CHAIN OF T CELL RECEPTOR INTERACTS W/ NEF OF SIV &HIV2P51RR000168 · NCRR · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI WESTMORELAND, SUSAN V. · 1985 to 2011
$139.3M
PROJECT 3: METABOLOMIC BIOMARKERS OF PARKINSON'S DISEASEP01ES016731 · NIEHS · EMORY UNIVERSITY · PI MILLER, GARY W · 2008 to 2012
$6.7M
Nuclear and Cytoplasmic Redox in Oxidative StressR01ES011195 · NIEHS · EMORY UNIVERSITY · PI JONES, DEAN PAUL · 2001 to 2011
$3.3M
A metabolomic model of aging in the common marmosetR01AG038746 · NIA · EMORY UNIVERSITY · PI JONES, DEAN PAUL, PROMISLOW, DANIEL EDWARD · 2010 to 2014
$2.5M
NCRR NIH HHS P51 RR000168NIA NIH HHS R01 AG038746NIEHS NIH HHS P01 ES016731NIEHS NIH HHS R01 ES011195
6 · The paper itself

Abstract

Studies of gene-environment (G × E) interactions require effective characterization of all environmental exposures from conception to death, termed the exposome. The exposome includes environmental exposures that impact health. Improved metabolic profiling methods are needed to characterize these exposures for use in personalized medicine. In the present study, we compared the analytic capability of dual chromatography-Fourier-transform mass spectrometry (DC-FTMS) to previously used liquid chromatography-FTMS (LC-FTMS) analysis for high-throughput, top-down metabolic profiling. For DC-FTMS, we combined data from sequential LC-FTMS analyses using reverse phase (C18) chromatography and anion exchange (AE) chromatography. Each analysis was performed with electrospray ionization in the positive ion mode and detection from

Indexed as

Anion exchangeExposomeFT-ICRLC/MSMetabolomicsPersonalized medicinePlasmaPredictive healthReverse phase

Identifiers

PMID26229523
PMCPMC4517297

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.