Evidence map›Paper›PMID 26229455›Full record

Trial reportInternational journal of chronic obstructive pulmonary disease2015

Self-reported alcohol intake and risk of acute exacerbations of chronic obstructive pulmonary disease: a prospective cohort study.

Erin E Wetherbee, Dennis E Niewoehner, Joseph H Sisson, Sarah M Lindberg, John E Connett, Ken M Kunisaki

Open access · goldAbstract readComparative StudyMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in International journal of chronic obstructive pulmonary disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Erin E WetherbeePulmonary Section, Minneapolis Veterans Affairs Health Care System, University of Minnesota, Minneapolis, MN, USA ; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Dennis E NiewoehnerPulmonary Section, Minneapolis Veterans Affairs Health Care System, University of Minnesota, Minneapolis, MN, USA ; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
Joseph H SissonPulmonary, Critical Care, Sleep and Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE, USA.
Sarah M LindbergDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
John E ConnettDivision of Biostatistics, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Ken M KunisakiPulmonary Section, Minneapolis Veterans Affairs Health Care System, University of Minnesota, Minneapolis, MN, USA ; Division of Pulmonary, Allergy, Critical Care and Sleep Medicine, Department of Medicine, University of Minnesota, Minneapolis, MN, USA.
University of Minnesota · USMinneapolis VA Health Care System · USUniversity of Nebraska Medical Center · US

Funding

COPD Clinical Research Network - Data Coordinating CenterU10HL074424 · NHLBI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI CONNETT, JOHN E · 2003 to 2011
$21.0M
ETHANOL MEDIATED CILIA MOTILITY DYSFUNCTIONR01AA008769 · NIAAA · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI SISSON, JOSEPH H · 1996 to 2016
$4.4M
Novel Strategies Targeting Acute Exacerbation of COPDU10HL074409 · NHLBI · DENVER HEALTH AND HOSPITAL AUTHORITY · PI ALBERT, RICHARD K · 2003 to 2007
$4.1M
COPD Exacerbations: Pharmacogenetic Approaches to TherapyU10HL074428 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI WASHKO, GEORGE R · 2003 to 2007
$3.4M
UAB/BVAMC Clinical Center in COPDU10HL074418 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI DRANSFIELD, MARK T · 2003 to 2007
$3.3M
Strategies to Improve COPD ManagementU10HL074407 · NHLBI · LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER · PI CASABURI, RICHARD · 2003 to 2007
$3.2M
COPD Clinical Research Network & Clinical Research Skills Core DevelopmentU10HL074408 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI CRINER, GERARD J · 2004 to 2007
$2.7M
Drug therapy for preventing COPD exacerbationsU10HL074416 · NHLBI · MINNESOTA VETERANS RESEARCH INST · PI NIEWOEHNER, DENNIS E. · 2003 to 2007
$2.7M
Clinical Center-COPD Clinical Research NetworkU10HL074441 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI SCHARF, STEVEN M · 2003 to 2006
$2.6M
COPD Clinical Research NetworkU10HL074431 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LAZARUS, STEPHEN C · 2003 to 2006
$2.2M
Strategies to Prevent COPD ExacerbationU10HL074422 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARTINEZ, FERNANDO J · 2004 to 2007
$2.0M
COPD Clinical Research NetworkU10HL074439 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SCIURBA, FRANK · 2004 to 2007
$1.7M
NHLBI NIH HHS HL074407NHLBI NIH HHS HL074408NHLBI NIH HHS HL074409NHLBI NIH HHS HL074416NHLBI NIH HHS HL074418NHLBI NIH HHS HL074422NHLBI NIH HHS HL074424NHLBI NIH HHS HL074428NHLBI NIH HHS HL074431NHLBI NIH HHS HL074439NHLBI NIH HHS HL074441NHLBI NIH HHS U10 HL074407NHLBI NIH HHS U10 HL074408NHLBI NIH HHS U10 HL074409NHLBI NIH HHS U10 HL074416NHLBI NIH HHS U10 HL074418NHLBI NIH HHS U10 HL074422NHLBI NIH HHS U10 HL074424NHLBI NIH HHS U10 HL074428NHLBI NIH HHS U10 HL074431NHLBI NIH HHS U10 HL074439NHLBI NIH HHS U10 HL074441NIAAA NIH HHS 5R01AA008769NIAAA NIH HHS R01 AA008769
6 · The paper itself

Abstract

objectiveTo evaluate the relationship between alcohol consumption and the risk of acute exacerbation of COPD (AECOPD). METHODS AND MEASUREMENTS: We conducted a secondary analysis of data previously collected in a large, multicenter trial of daily azithromycin in COPD. To analyze the relationship between amount of baseline self-reported alcohol consumption in the past 12 months and subsequent AECOPD, we categorized the subjects as minimal (<1 drink/month), light-to-moderate (1-60 drinks/month), or heavy alcohol users (>60 drinks/month). The primary outcome was time to first AECOPD and the secondary outcome was AECOPD rate during the 1-year study period.

resultsOf the 1,142 enrolled participants, 1,082 completed baseline alcohol questionnaires and were included in this analysis. Six hundred and forty-five participants reported minimal alcohol intake, 363 reported light-to-moderate intake, and 74 reported heavy intake. There were no statistically significant differences in median time to first AECOPD among minimal (195 days), light-to-moderate (241 days), and heavy drinkers (288 days) (P=0.11). The mean crude rate of AECOPD did not significantly differ between minimal (1.62 events per year) and light-to-moderate (1.44 events per year) (P=0.095), or heavy drinkers (1.68 events per year) (P=0.796). There were no significant differences in hazard ratios for AECOPD after adjustment for multiple covariates.

conclusionAmong persons with COPD at high risk of exacerbation, we found no significant relationship between self-reported baseline alcohol intake and subsequent exacerbations. The number of patients reporting heavy alcohol intake was small and further study is needed to determine the effect of heavy alcohol intake on AECOPD risk.

Indexed as

Self ReportAgedAlcohol DrinkingAnti-Bacterial AgentsAzithromycinChi-Square DistributionDisease ProgressionFemaleHumansMaleMiddle AgedMultivariate AnalysisProportional Hazards ModelsProspective StudiesPulmonary Disease, Chronic ObstructiveRisk AssessmentAnti-Bacterial AgentsAzithromycinalcoholalcoholismchronic obstructiveethanolpulmonary disease

Identifiers

PMID26229455
PMCPMC4516185
OpenAlexW1703357272

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.