Evidence map›Paper›PMID 26229447›Full record

ArticleDrug design, development and therapy2015

Dendrimer-coupled sonophoresis-mediated transdermal drug-delivery system for diclofenac.

Bin Huang, Wei-Jiang Dong, Gao-Yi Yang, Wei Wang, Cong-Hua Ji, Fei-Ni Zhou

Open access · goldAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Drug design, development and therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.2field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. [Classification and Application of Ultrasound-Responsive Nanomaterials in Anti-Inflammatory Therapy].Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2024
    Review
  5. Review
  6. Review
  7. Low-Frequency Sonophoresis: A Promising Strategy for Enhanced Transdermal Delivery.Advances in pharmacological and pharmaceutical sciences · 2024
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Article
  13. Review
  14. Review
  15. Recent advances in ultrasound-based transdermal drug delivery.International journal of nanomedicine · 2018
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Bin HuangDepartment of Ultrasound, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
Wei-Jiang DongDepartment of Ultrasonography, Tongxiang Chinese Medicine Hospital, Jiaxing, People's Republic of China.
Gao-Yi YangDepartment of Ultrasound, Hangzhou Red Cross Hospital, Hangzhou, People's Republic of China.
Wei WangDepartment of Ultrasound, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
Cong-Hua JiDepartment of Ultrasound, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
Fei-Ni ZhouDepartment of Medical Records and Statistics, First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People's Republic of China.
Zhejiang Chinese Medical University · CNFirst Hospital of Jiaxing · CNHangzhou Red Cross Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The purpose of the present study was to develop a novel transdermal drug-delivery system comprising a polyamidoamine dendrimer coupled with sonophoresis to enhance the permeation of diclofenac (DF) through the skin. The novel transdermal drug-delivery system was developed by using a statistical Plackett-Burman design. Hairless male Wistar rat skin was used for the DF-permeation study. Coupling media concentration, ultrasound-application time, duty cycle, distance from probe to skin, and a third-generation polyamidoamine-dendrimer concentration were selected as independent variables, while in vitro drug release was selected as a dependent variable. Independent variables were found to be statistically significant (P<0.05). DF gel without dendrimer and ultrasound treatment to skin (passive delivery, run 13) showed 56.69 µg/cm(2) cumulative drug permeated through the skin, while the DF-dendrimer gel without sonophoresis treatment (run 14) showed 257.3 µg/cm(2) cumulative drug permeated through the skin after 24 hours. However, when the same gel was applied to sonophoresis-treated skin, drastic permeation enhancement was observed. In the case of run 3, the cumulative drug that permeated through the skin was 935.21 µg/cm(2). It was concluded that dendrimer-coupled sonophoresis-mediated transdermal drug delivery system has the potential to enhance the permeation of DF through the skin.

Indexed as

DendrimersDrug Delivery SystemsAdministration, CutaneousAnimalsAnti-Inflammatory Agents, Non-SteroidalDiclofenacDrug LiberationGelsMalePermeabilityPolyaminesRatsRats, WistarSkin AbsorptionUltrasonographyAnti-Inflammatory Agents, Non-SteroidalDendrimersDiclofenacGelsPoly(amidoamine)Polyaminespermeation enhancerspolyamidoaminesonophoresisstratum corneumultrasound

Identifiers

PMID26229447
PMCPMC4517524
OpenAlexW1899098391

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.