ArticleWorld journal of gastroenterology2015
Restraint stress induces and exacerbates intestinal inflammation in interleukin-10 deficient mice.
Article in World journal of gastroenterology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 15 citations in OpenAlex.
- Article
- Restraint Stress-Induced Neutrophil Inflammation Contributes to Concurrent Gastrointestinal Injury in Mice.International journal of molecular sciences · 2024Article
- Role of melatonin in intestinal mucosal injury induced by restraint stress in mice.Pharmaceutical biology · 2020Article
- Article
- Protective effects of ColomastInternational journal of molecular sciences · 2020Article
- Impact of chronic immobilization stress on parameters of colonic homeostasis in BALB/c mice.Molecular medicine reports · 2019Article
- Restraint devices for repetitive transcranial magnetic stimulation in mice and rats.Brain and behavior · 2019Article
- Stress Triggers Flare of Inflammatory Bowel Disease in Children and Adults.Frontiers in pediatrics · 2019Review
- Visceral Inflammation and Immune Activation Stress the Brain.Frontiers in immunology · 2017Review
- Restraint stress-associated gastrointestinal injury and implications from the Evans blue-fed restraint stress mouse model.Tzu chi medical journalReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the effects of restraint stress on chronic colitis in interleukin (IL)-10 deficient (IL-10(-/-)) mice.
methodsThe first experiment compared the effect of restraint stress on the development of intestinal inflammation in wild-type and IL-10(-/-) mice. Both wild-type and IL-10(-/-) mice were physically restrained in a well-ventilated, 50 cm(3) conical polypropylene tube for 2 h per day for three consecutive days. The second experiment was performed to assess the effect of restraint stress on exacerbation of colitis induced by piroxicam in IL-10(-/-) mice. The IL-10(-/-) mice were exposed to restraint stress for 2 h per day for 3 consecutive days, and then treated with piroxicam for 4 d at a dose of 200 ppm administered in the rodent chow.
resultsIn the first experiment, none of the wild-type mice with or without restraint stress showed clinical and histopathological abnormality in the gut. However, IL-10(-/-) mice exposed to restraint stress exhibited histologically significant intestinal inflammation as compared to those without restraint stress. In the second experiment, restraint stress significantly reduced body weight and increased the severity of intestinal inflammation assessed by histopathologic grading in IL-10(-/-) mice. Colonic IL12p40 mRNA expression was strongly increased in mice exposed to restraint stress.
conclusionThis novel animal model could be useful in future study of psychological stress in the pathogenesis of inflammatory bowel disease.
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