SynthesisBulletin of the World Health Organization2015
Estimates of alcohol-related oesophageal cancer burden in Japan: systematic review and meta-analyses.
Synthesis in Bulletin of the World Health Organization, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 42 citations in OpenAlex.
- Association between physical activity and digestive-system cancer: An updated systematic review and meta-analysis.Journal of sport and health science · 2021Pooled it
- Modifiable factors and esophageal cancer: a systematic review of published meta-analyses.Journal of gastroenterology · 2018Pooled it
- The relationship between different dimensions of alcohol use and the burden of disease-an update.Addiction (Abingdon, England) · 2017Pooled it
- Neoadjuvant Chemoradiotherapy Improving Survival Outcomes for Esophageal Carcinoma: An Updated Meta-analysis.Chinese medical journal · 2016Pooled it
- Article
- Analysis of Novel DNA Adducts Derived from Acetaldehyde.Biomolecules · 2025Article
- Global, regional, and national burden of esophageal cancer using the 2019 global burden of disease study.Scientific reports · 2025Article
- The role of alcohol control policies in the reversal of alcohol consumption levels and resulting attributable harms in China.Alcohol (Fayetteville, N.Y.) · 2024Review
- Oral Pathogenic Bacteria and the Oral-Gut-Liver Axis: A New Understanding of Chronic Liver Diseases.Diagnostics (Basel, Switzerland) · 2023Review
- Global burden and temporal trends in incidence and mortality of oesophageal cancer.Journal of advanced research · 2023Article
- Using Direct and Indirect Estimates for Alcohol-Attributable Mortality: A Modelling Study Using the Example of Lithuania.European addiction research · 2023Article
- Changing epidemiology of cirrhosis from 2010 to 2019: results from the Global Burden Disease study 2019.Annals of medicine · 2023Article
- Secular trends in the mortality of gastrointestinal cancers across China, Japan, the US, and India: An age-period-cohort, Joinpoint analyses, and Holt forecasts.Frontiers in public health · 2022Article
- Review
- Anti-Tumor Effects of Astaxanthin by Inhibition of the Expression of STAT3 in Prostate Cancer.Marine drugs · 2020Article
- Alcohol Use and Cancers of the Gastrointestinal Tract. Epidemiology and Preventive Implications.Frontiers in oncology · 2020Article
- Does Alcohol Use Affect Cancer Risk?Current nutrition reports · 2019Review
- Recent Topics and Perspectives on Esophageal Cancer in Japan.JMA journal · 2018Article
- Impact of Alcohol Intake and Drinking Patterns on Mortality From All Causes and Major Causes of Death in a Japanese Population.Journal of epidemiology · 2018Article
- Alcohol accumulation promotes esophagitis via pyroptosis activation.International journal of biological sciences · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo refine estimates of the burden of alcohol-related oesophageal cancer in Japan.
methodsWe searched PubMed for published reviews and original studies on alcohol intake, aldehyde dehydrogenase polymorphisms, and risk for oesophageal cancer in Japan, published before 2014. We conducted random-effects meta-analyses, including subgroup analyses by aldehyde dehydrogenase variants. We estimated deaths and loss of disability-adjusted life years (DALYs) from oesophageal cancer using exposure distributions for alcohol based on age, sex and relative risks per unit of exposure.
findingsWe identified 14 relevant studies. Three cohort studies and four case-control studies had dose-response data. Evidence from cohort studies showed that people who consumed the equivalent of 100 g/day of pure alcohol had an 11.71 fold, (95% confidence interval, CI: 2.67-51.32) risk of oesophageal cancer compared to those who never consumed alcohol. Evidence from case-control studies showed that the increase in risk was 33.11 fold (95% CI: 8.15-134.43) in the population at large. The difference by study design is explained by the 159 fold (95% CI: 27.2-938.2) risk among those with an inactive aldehyde dehydrogenase enzyme variant. Applying these dose-response estimates to the national profile of alcohol intake yielded 5279 oesophageal cancer deaths and 102,988 DALYs lost - almost double the estimates produced by the most recent global burden of disease exercise.
conclusionUse of global dose-response data results in an underestimate of the burden of disease from oesophageal cancer in Japan. Where possible, national burden of disease studies should use results from the population concerned.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.