ArticleEuropean radiology2016
Quantitative susceptibility mapping in patients with systemic lupus erythematosus: detection of abnormalities in normal-appearing basal ganglia.
Article in European radiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- A multidimensional analysis of neuropsychiatric lupus: clinical, biological and imaging insights from systematic evidence.Frontiers in immunology · 2026Pooled it
- Symmetrical basal ganglia involvement in pediatric neuropsychiatric lupus: MRI findings in a rare presentation.Radiology case reports · 2026Article
- The Diagnostic Value of Contrast-Enhanced Vessel Wall MRI for Diagnosing Neuropsychiatric Systemic Lupus Erythematosus.Journal of magnetic resonance imaging : JMRI · 2025Article
- Assessing grey matter structural alterations in systemic lupus erythematosus using synthetic MRI.Lupus science & medicine · 2025Article
- Serotonin Syndrome-Mimicking Manifestations in a Patient with Systemic Lupus Erythematosus.Journal of clinical medicine · 2024Article
- Bilateral striopallidal calcinosis secondary to systemic lupus erythematosus.Radiology case reports · 2022Article
- Quantitative susceptibility mapping in the thalamus and basal ganglia of systemic lupus erythematosus patients with neuropsychiatric complaints.NeuroImage. Clinical · 2021Article
- Article
- Significance andFrontiers in immunology · 2018Review
- Quantitative susceptibility mapping of the motor cortex: a comparison of susceptibility among patients with amyotrophic lateral sclerosis, cerebrovascular disease, and healthy controls.Neuroradiology · 2017Article
- Enlarged perivascular spaces are associated with the disease activity in systemic lupus erythematosus.Scientific reports · 2017Article
- Clinical quantitative susceptibility mapping (QSM): Biometal imaging and its emerging roles in patient care.Journal of magnetic resonance imaging : JMRI · 2017Review
- Zebra sign of precentral gyri in amyotrophic lateral sclerosis: A novel finding using phase difference enhanced (PADRE) imaging-initial results.European radiology · 2016Article
- Structure Prior Effects in Bayesian Approaches of Quantitative Susceptibility Mapping.BioMed research international · 2016Article
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Authors and funding
15 authors.
Funding
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Abstract
objectivesTo evaluate whether quantitative susceptibility mapping (QSM) can be employed to detect abnormalities within normal-appearing basal ganglia on conventional MRI in patients with neuropsychiatric systemic lupus erythematosus (NPSLE).
methodsFor 33 SLE patients (13 NPSLE and 20 non-NPSLE patients) and 23 age/sex-matched controls, two radiologists independently measured the mean QSM and R2* values in various brain structures that appeared to be normal on conventional MR images. These values in each brain structure were compared among the two SLE groups and controls.
resultsRegarding the putamen, the NPSLE patients showed significantly higher QSM values than the non-NPSLE patients and controls (p < 0.05). For the lateral globus pallidus, both SLE groups showed significantly higher QSM values than the controls (p < 0.05). The R2* values were not significantly different between both SLE groups. The NPSLE patients showed a significant correlation between the mean QSM values in putamen and the disease duration (r = 0.63, p < 0.05). For the interobserver agreement, the QSM value was superior to the R2* value (0.690 vs. 0.446, Kendall W value).
conclusionsQSM can be used to identify increased susceptibility of the basal ganglia appearing to be normal on conventional MR images in NPSLE patients. KEY POINTS: • QSM values in the putamen are significantly higher in NPSLE than non-NPSLE. • NPSLE patients show correlation between QSM values in the putamen and disease duration. • QSM is more sensitive than R2* mapping for detecting subtle changes.
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