ArticleMolecular imaging and biology2016
Intraoperative Molecular Imaging of Lung Adenocarcinoma Can Identify Residual Tumor Cells at the Surgical Margins.
Article in Molecular imaging and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 41 citations in OpenAlex.
- Feasibility of indocyanine green-guided localization of pulmonary nodules in children with solid tumors.Pediatric blood & cancer · 2023Trial
- Real-time surveillance of surgical margins via ICG-based near-infrared fluorescence imaging in patients with OSCC.World journal of surgical oncology · 2020Trial
- Intraoperative Molecular Imaging in Thoracic Oncology: Expanding the Observable Disease Space.Cancers · 2026Review
- Translational development of an SGLT2-targeted near-infrared contrast agent for intraoperative imaging of early-stage lung cancer.EJNMMI research · 2026Article
- Revisiting the standards of cancer detection and therapy alongside their comparison to modern methods.World journal of methodology · 2024Review
- Evaluation of OTL38-Generated Tumor-to-Background Ratio in Intraoperative Molecular Imaging-Guided Lung Cancer Resections.Molecular imaging and biology · 2023Article
- Intraoperative identification of pulmonary nodules during minimally invasive thoracic surgery: a narrative review.Quantitative imaging in medicine and surgery · 2022Review
- Multiplexed imaging in oncology.Nature biomedical engineering · 2022Review
- Nanotechnology-enhanced immunotherapy for metastatic cancer.Innovation (Cambridge (Mass.)) · 2021Review
- Recent fluorescence imaging technology applications of indocyanine green in general thoracic surgery.Surgery today · 2020Review
- Intraoperative Detection and Assessment of Lung Nodules.Surgical oncology clinics of North America · 2020Review
- Comparison of a Short Versus Long Stokes Shift Near-Infrared Dye During Intraoperative Molecular Imaging.Molecular imaging and biology · 2020Article
- Intraoperative fluorescence imaging in thoracic surgery.Journal of surgical oncology · 2018Review
- Intraoperative Molecular Imaging in Lung Cancer: The State of the Art and the Future.Molecular therapy : the journal of the American Society of Gene Therapy · 2018Article
- Molecular imaging of pulmonary diseases.Respiratory research · 2018Review
- Novel solid-phase strategy for the synthesis of ligand-targeted fluorescent-labelled chelating peptide conjugates as a theranostic tool for cancer.Beilstein journal of organic chemistry · 2018Article
- Evaluation of a Centyrin-Based Near-Infrared Probe for Fluorescence-Guided Surgery of Epidermal Growth Factor Receptor Positive Tumors.Bioconjugate chemistry · 2017Article
- Improved Intraoperative Detection of Ovarian Cancer by Folate Receptor Alpha Targeted Dual-Modality Imaging.Molecular pharmaceutics · 2017Article
- Intraoperative near-infrared imaging of mesothelioma.Translational lung cancer research · 2017Review
- Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 1 country.
Funding
Abstract
purposeDuring lung surgery, identification of surgical margins is challenging. We hypothesized that molecular imaging with a fluorescent probe to pulmonary adenocarcinomas could enhance residual tumor during resection. PROCEDURES: Mice with flank tumors received a contrast agent targeting folate receptor alpha. Optimal dose and time of injection was established. Margin detection was compared using traditional methods versus molecular imaging. A pilot study was then performed in three humans with lung adenocarcinoma.
resultsThe peak tumor-to-background ratio (TBR) of murine tumors was 3.9. Fluorescence peaked at 2 h and was not improved beyond 0.1 mg/kg. Traditional inspection identified 30% of mice with positive margins. Molecular imaging identified an additional 50% of residual tumor deposits (p < 0.05). The fluorescent probe visually enhanced all human tumors with a mean TBR of 3.5.
conclusionsMolecular imaging is an important adjunct to traditional inspection to identify surgical margins after tumor resection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.