ArticleThe European journal of neuroscience2015
Lesions of the paraventricular nucleus of the thalamus differentially affect sign- and goal-tracking conditioned responses.
Article in The European journal of neuroscience, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Article
- A brainstem-thalamocortical circuit mediates postoperative pain duration induced by sleep deprivation.Behavioral and brain functions : BBF · 2026Article
- The Role of the Posterior Paraventricular Nucleus of the Thalamus in Food Deprivation-Induced Heroin-Seeking Relapse, in Male and Female Rats.Addiction biology · 2026Article
- Paraventricular thalamic inputs to the ventral pallidum shape reward seeking during threat and fear responding in extinction.Behavioral neuroscience · 2025Article
- Genotype-dependent functional role of the anterior and posterior paraventricular thalamus in pavlovian conditioned approach.Psychopharmacology · 2025Article
- Leveraging individual differences in cue-reward learning to investigate the psychological and neural basis of shared psychiatric symptomatology: The sign-tracker/goal-tracker model.Behavioral neuroscience · 2024Review
- The Paraventricular Thalamic Nucleus and Its Projections in Regulating Reward and Context Associations.eNeuro · 2024Article
- Separating desire from prediction of outcome value.Trends in cognitive sciences · 2023Review
- Inhibition of a cortico-thalamic circuit attenuates cue-induced reinstatement of drug-seeking behavior in "relapse prone" male rats.Psychopharmacology · 2022Article
- Perioperative sleep deprivation activates the paraventricular thalamic nucleus resulting in persistent postoperative incisional pain in mice.Frontiers in neuroanatomy · 2022Article
- A hypothalamic-thalamostriatal circuit that controls approach-avoidance conflict in rats.Nature communications · 2021Article
- The Function of Paraventricular Thalamic Circuitry in Adaptive Control of Feeding Behavior.Frontiers in behavioral neuroscience · 2021Article
- Thalamo-Nucleus Accumbens Projections in Motivated Behaviors and Addiction.Frontiers in systems neuroscience · 2021Review
- The Paraventricular Thalamus as a Critical Node of Motivated BehaviorFrontiers in integrative neuroscience · 2021Article
- Central Thalamic-Medial Prefrontal Control of Adaptive Responding in the Rat: Many Players in the Chamber.Frontiers in behavioral neuroscience · 2021Article
- The lateral hypothalamus and orexinergic transmission in the paraventricular thalamus promote the attribution of incentive salience to reward-associated cues.Psychopharmacology · 2020Article
- Psychostimulant-Induced Adaptations in Nucleus Accumbens Glutamatergic Transmission.Cold Spring Harbor perspectives in medicine · 2020Review
- A systems-neuroscience model of phasic dopamine.Psychological review · 2020Article
- Mapping sign-tracking and goal-tracking onto human behaviors.Neuroscience and biobehavioral reviews · 2020Review
- Heterogeneity in the Paraventricular Thalamus: The Traffic Light of Motivated Behaviors.Frontiers in behavioral neuroscience · 2020Article
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4 authors.
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Abstract
Recently, evidence has emerged suggesting a role for the paraventricular nucleus of the thalamus (PVT) in the processing of reward-associated cues. However, the specific role of the PVT in these processes has yet to be elucidated. Here we use an animal model that captures individual variation in response to discrete reward-associated cues to further assess the role of the PVT in stimulus-reward learning. When rats are exposed to a Pavlovian conditioning paradigm, wherein a discrete cue predicts food reward, two distinct conditioned responses emerge. Some rats, termed sign-trackers, approach and manipulate the cue, whereas others, termed goal-trackers, approach the location of reward delivery upon cue presentation. For both sign- and goal-trackers the cue is a predictor, but only for sign-trackers is it also an incentive stimulus. We investigated the role of the PVT in the acquisition and expression of these conditioned responses using an excitotoxic lesion. Results indicate that PVT lesions prior to acquisition amplify the differences between phenotypes - increasing sign-tracking and attenuating goal-tracking behavior. Lesions of the PVT after rats had acquired their respective conditioned responses also attenuated the expression of the goal-tracking response, and increased the sign-tracking response, but did so selectively in goal-trackers. These results suggest that the PVT acts to suppress the attribution of incentive salience to reward cues, as disruption of the functional activity within this structure enhances the tendency to sign-track.
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