ArticleDrug and alcohol dependence2015
Hyperactivation to pleasant interoceptive stimuli characterizes the transition to stimulant addiction.
Article in Drug and alcohol dependence, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Neuroimaging Impaired Response Inhibition and Salience Attribution in Human Drug Addiction: A Systematic Review.Neuron · 2018Pooled it
- Pooled it
- Anticipation of monetary reward in amygdala, insula, caudate are predictors of pleasure sensitivity to d-Amphetamine administration.Drug and alcohol dependence · 2020Trial
- Gamma-Hydroxybutyrate Increases Resting-State Limbic Perfusion and Body and Emotion Awareness in Humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Trial
- Interoceptive Processing in Substance Use Disorders (SUDs): From the Neuroanatomy to Insights from Computational Models and Predictive Coding Frameworks.Current topics in behavioral neurosciences · 2025Review
- Interoception Within the Context of Impulsivity and Addiction.Current addiction reports · 2023Review
- Mindfulness-Based Interventions for the Treatment of Aberrant Interoceptive Processing in Substance Use Disorders.Brain sciences · 2022Review
- Causal Relationship between Physiological and Pathological Processes in the Brain and in the Gastrointestinal Tract: The Brain-Intestine Axis.Biophysics · 2022Article
- Prior Methamphetamine Use Disorder History Does Not Impair Interoceptive Processing of Soft Touch in HIV Infection.Viruses · 2021Article
- Low-dose alcohol: Interoceptive and molecular effects and the role of dentate gyrus in rats.Addiction biology · 2021Article
- Increased anticipatory brain response to pleasant touch in women remitted from bulimia nervosa.Translational psychiatry · 2020Article
- Multimodal neurocognitive markers of interoceptive tuning in smoked cocaine.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Article
- The Cortical Neuroimmune Regulator TANK Affects Emotional Processing and Enhances Alcohol Drinking: A Translational Study.Cerebral cortex (New York, N.Y. : 1991) · 2019Article
- Neural hypersensitivity to pleasant touch in women remitted from anorexia nervosa.Translational psychiatry · 2018Article
- Insular and cingulate attenuation during decision making is associated with future transition to stimulant use disorder.Addiction (Abingdon, England) · 2017Article
- Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
aimsAltered interoception, how the brain processes afferents from the body, may contribute to the urge to take drugs, and subsequently, the development of addiction. Although chronic stimulant dependent individuals exhibit attenuated brain responses to pleasant interoceptive stimuli, it is unclear whether this deficit exists early-on in the process of transition to stimulant addiction.
methodsTo this end, we compared problem stimulant users (PSU; n=18), desisted stimulant users (DSU; n=15), and stimulant naïve comparison subjects (CTL; n=15) during functional magnetic resonance imaging (fMRI) while they anticipated and experienced pleasant soft touch (slow brushstroke to the palm and forearm).
resultsGroups did not differ in behavioral performance or visual analog scale ratings of soft touch stimuli. fMRI results indicated that PSU exhibited greater right anterior insula, left inferior frontal gyrus, and right superior frontal gyrus activation than DSU and CTL during the anticipation and experience of soft touch. Moreover, during the experience of soft touch, PSU demonstrated higher bilateral precentral gyrus/middle insula and right posterior temporal gyrus activation than DSU and CTL.
conclusionsIn contrast to chronic stimulant dependence, individuals who have recently developed stimulant use disorders show exaggerated neural processing of pleasant interoceptive stimuli. Thus, increased processing of body-relevant information signaling pleasant touch in those individuals who develop problem use may be a predictive interoceptive biomarker. However, future investigations will need to determine whether the combination of probing pleasant interoception using neuroimaging is sufficiently sensitive and specific to help identify individuals at high risk for future problem use.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.