CrossTalk opposing view: 5-HT is not necessary for peristalsis.

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

Who cites it

28 citing papers in PubMed.

1. Serotonergic Control of Gastrointestinal Development, Motility, and Inflammation.Comprehensive Physiology · 2023
   Article
2. Nutrients · 2023
   Article
3. Neural signalling of gut mechanosensation in ingestive and digestive processes.Nature reviews. Neuroscience · 2022
   Review
4. The tactile sensors of the gut.Trends in neurosciences · 2022
   Article
5. Specialized Mechanosensory Epithelial Cells in Mouse Gut Intrinsic Tactile Sensitivity.Gastroenterology · 2022
   Article
6. The Shaggy Dog Story of Enteric Signaling: Serotonin, a Molecular Megillah.Advances in experimental medicine and biology · 2022
   Article
7. Optogenetic activation of the distal colon epithelium engages enteric nervous system circuits to initiate motility patterns.American journal of physiology. Gastrointestinal and liver physiology · 2021
   Article
8. Colonic Motility Is Improved by the Activation of 5-HTGastroenterology · 2021
   Article
9. The α isoform of cGMP-dependent protein kinase 1 (PKG1α) is expressed and functionally important in intrinsic primary afferent neurons of the guinea pig enteric nervous system.Neurogastroenterology and motility · 2021
   Article
10. Serotonin Deficiency Is Associated With Delayed Gastric Emptying.Gastroenterology · 2021
    Article
11. International Union of Basic and Clinical Pharmacology. CX. Classification of Receptors for 5-hydroxytryptamine; Pharmacology and Function.Pharmacological reviews · 2021
    Review
12. Localization of the Serotonin Transporter in the Dog Intestine and Comparison to the Rat and Human Intestines.Frontiers in veterinary science · 2021
    Article
13. Novel aspects of enteric serotonergic signaling in health and brain-gut disease.American journal of physiology. Gastrointestinal and liver physiology · 2020
    Review
14. Reprint of: Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders.Pharmacological research · 2019
    Article
15. Sugar Responses of Human Enterochromaffin Cells Depend on Gut Region, Sex, and Body Mass.Nutrients · 2019
    Article
16. The Influence of the Gut Microbiome on Host Metabolism Through the Regulation of Gut Hormone Release.Frontiers in physiology · 2019
    Article
17. The touchy business of gastrointestinal (GI) mechanosensitivity.Brain research · 2018
    Review
18. Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders.Pharmacological research · 2018
    Review
19. Enterochromaffin 5-HT cells - A major target for GLP-1 and gut microbial metabolites.Molecular metabolism · 2018
    Article
20. The Regulation of Peripheral Metabolism by Gut-Derived Hormones.Frontiers in endocrinology · 2018
    Review

Corrections and comments

• Commented on by
  Rebuttal from Terence K. Smith and Michael D. Gershon.2015
• Commented on by
  Rebuttal from Nick J. Spencer, Tiong Cheng Sia, Simon J Brookes, Marcello Costa and Damien J. Keating.2015

Authors and funding

5 authors.

Funding

No grant is acknowledged in the PubMed record.

Abstract

PubMed holds no abstract for this paper.

Indexed as