ArticleScientific reports2015
The relationship between nociceptive brain activity, spinal reflex withdrawal and behaviour in newborn infants.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 70 citations in OpenAlex.
- Effect of parental touch on relieving acute procedural pain in neonates and parental anxiety (Petal): a multicentre, randomised controlled trial in the UK.The Lancet. Child & adolescent health · 2024Trial
- Birth experience in newborn infants is associated with changes in nociceptive sensitivity.Scientific reports · 2019Trial
- Analgesic efficacy and safety of morphine in the Procedural Pain in Premature Infants (Poppi) study: randomised placebo-controlled trial.Lancet (London, England) · 2018Trial
- Electroencephalography during acute painful procedures in neonates: a scoping review.Pain reports · 2026Review
- Objective Detection of Newborn Infant Acute Procedural Pain Using EEG and Machine Learning Algorithms.Paediatric & neonatal pain · 2025Article
- Behavioral and physiological pain structures of PIPP-R and parental stress: structural equation modeling approach.Pediatric research · 2025Article
- A machine learning artefact detection method for single-channel infant event-related potential studies.Journal of neural engineering · 2024Article
- Sensory event-related potential morphology predicts age in premature infants.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2024Article
- The fetal pain paradox.Frontiers in pain research (Lausanne, Switzerland) · 2023Review
- Premature infants display discriminable behavioral, physiological, and brain responses to noxious and nonnoxious stimuli.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Early life inflammation is associated with spinal cord excitability and nociceptive sensitivity in human infants.Nature communications · 2022Article
- Article
- The impact of premature extrauterine exposure on infants' stimulus-evoked brain activity across multiple sensory systems.NeuroImage. Clinical · 2022Article
- Revisions to the IASP definition of pain-What does this mean for children?Paediatric & neonatal pain · 2021Article
- Functional and diffusion MRI reveal the neurophysiological basis of neonates' noxious-stimulus evoked brain activity.Nature communications · 2021Article
- Quantifying noxious-evoked baseline sensitivity in neonates to optimise analgesic trials.eLife · 2021Observational
- Can Event-Related Potentials Evoked by Heel Lance Assess Pain Processing in Neonates? A Systematic Review.Children (Basel, Switzerland) · 2021Review
- Using sensor-fusion and machine-learning algorithms to assess acute pain in non-verbal infants: a study protocol.BMJ open · 2021Article
- Article
- Inferring pain experience in infants using quantitative whole-brain functional MRI signatures: a cross-sectional, observational study.The Lancet. Digital health · 2020Observational
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Measuring infant pain is complicated by their inability to describe the experience. While nociceptive brain activity, reflex withdrawal and facial grimacing have been characterised, the relationship between these activity patterns has not been examined. As cortical and spinally mediated activity is developmentally regulated, it cannot be assumed that they are predictive of one another in the immature nervous system. Here, using a new experimental paradigm, we characterise the nociceptive-specific brain activity, spinal reflex withdrawal and behavioural activity following graded intensity noxious stimulation and clinical heel lancing in 30 term infants. We show that nociceptive-specific brain activity and nociceptive reflex withdrawal are graded with stimulus intensity (p < 0.001), significantly correlated (r = 0.53, p = 0.001) and elicited at an intensity that does not evoke changes in clinical pain scores (p = 0.55). The strong correlation between reflex withdrawal and nociceptive brain activity suggests that movement of the limb away from a noxious stimulus is a sensitive indication of nociceptive brain activity in term infants. This could underpin the development of new clinical pain assessment measures.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.