ArticleJournal of psychiatric research2015
Elucidating X chromosome influences on Attention Deficit Hyperactivity Disorder and executive function.
Article in Journal of psychiatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.
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Who cites it
26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Increased somatic mosaicism in autosomal and X chromosomes for suicide death.Molecular psychiatry · 2025Pooled it
- Clinical practice guidelines for the care of girls and women with Turner syndrome.European journal of endocrinology · 2024Guideline
- Executive Functions in Children and Adolescents with Turner Syndrome: A Systematic Review and Meta-Analysis.Neuropsychology review · 2018Pooled it
- [Neuropsychiatric manifestations of sex chromosome aberrations-Clinical and therapeutic aspects of neuropsychiatric care].Der Nervenarzt · 2026Review
- Psychiatric disorders and comorbidity in women with Turner Syndrome: a retrospective national cohort study.Translational psychiatry · 2024Article
- Anxiety in Turner syndrome: Engaging community to address barriers and facilitators to diagnosis and care.American journal of medical genetics. Part A · 2024Article
- Syndrome-Specific Neuroanatomical Phenotypes in Girls With Turner and Noonan Syndromes.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2024Article
- Neurocognitive and psychosocial profiles of children with Turner syndrome.Annals of pediatric endocrinology & metabolism · 2023Article
- Reduced effects of social feedback on learning in Turner syndrome.Scientific reports · 2023Article
- Adolescent brain development in girls with Turner syndrome.Human brain mapping · 2023Article
- Clinical and Molecular Aspects Associated with Defects in the Transcription Factor POU3F4: A Review.Biomedicines · 2023Review
- Neuropsychological and mental health concerns in a multicenter clinical sample of youth with turner syndrome.American journal of medical genetics. Part A · 2023Article
- Turner syndrome: French National Diagnosis and Care Protocol (NDCP; National Diagnosis and Care Protocol).Orphanet journal of rare diseases · 2022Article
- Effect of sex chromosome number variation on attention-deficit/hyperactivity disorder symptoms, executive function, and processing speed.Developmental medicine and child neurology · 2022Article
- Neurodevelopmental and psychiatric disorders in females with Turner syndrome: a population-based study.Journal of neurodevelopmental disorders · 2021Article
- Early Development of Infants with Turner Syndrome.Journal of developmental and behavioral pediatrics : JDBP · 2020Article
- Altered Brain Structure in Infants with Turner Syndrome.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Article
- Clinical developmental, neuropsychological, and social-emotional features of Turner syndrome.American journal of medical genetics. Part C, Seminars in medical genetics · 2019Review
- Sex differences in psychiatric disorders: what we can learn from sex chromosome aneuploidies.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2019Review
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
objectiveTo identify distinct behavioral and cognitive profiles associated with ADHD in Turner syndrome (TS), relative to idiopathic ADHD and neurotypical controls, in order to elucidate X-linked influences contributing to ADHD.
methodsWe used a multilevel-model approach to compare 49 girls with TS to 37 neurotypical females, aged 5-12, on established measures of behavior (BASC-2) and neurocognitive function (NEPSY). We further compared girls with TS to BASC-2 and NEPSY age-matched reference data obtained from children with idiopathic ADHD.
resultsWithin the TS group, 51% scored at or above the "at-risk" range for ADHD-associated behaviors on the BASC-2 (TS/+ADHD). The BASC-2 behavioral profile in this TS/+ADHD-subgroup was comparable to a reference group of boys with ADHD with respect to attentional problems and hyperactivity. However, the TS/+ADHD-subgroup had significantly higher hyperactivity scores relative to a reference sample of girls with ADHD (p = 0.016). The behavioral profile in TS was associated with significantly lower attention and executive function scores on the NEPSY relative to neurotypical controls (p = 0.015); but was comparable to scores from a reference sample of children with idiopathic ADHD. Deficits in attention and executive function were not observed in girls with TS having low levels of ADHD-associated behavior (TS/-ADHD).
conclusionsADHD-associated behavioral and cognitive problems in TS are prevalent and comparable in severity to those found in children with idiopathic ADHD. The ADHD phenotype in TS also appears relatively independent of cognitive features typically associated with TS, like visuospatial weaknesses. These findings suggest that X-linked haploinsufficiency and downstream biological effects contribute to increased risk for ADHD.
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