Evidence map›Paper›PMID 26228411›Full record

ArticleJournal of psychiatric research2015

Examining gene-environment interactions in comorbid depressive and disruptive behavior disorders using a Bayesian approach.

Molly Adrian, Cara Kiff, Chris Glazner, Ruth Kohen, Julia Helen Tracy, Chuan Zhou, Elizabeth McCauley, Ann Vander Stoep

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Intertwined associations between oxytocin, immune system and major depressive disorder.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2023
    Review
  5. Review
  6. Article
  7. Little Evidence of Modified Genetic Effect of rs16969968 on Heavy Smoking Based on Age of Onset of Smoking.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2021
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Molly AdrianDepartment of Psychiatry and Behavioral Sciences, University of Washington, USA; Seattle Children's Research Institute, Center for Child Health, Behavior, and Development, USA. Electronic address: adriam@uw.edu.
Cara KiffUniversity of California Los Angeles, Semel Institute, USA.
Chris GlaznerDepartment of Statistics, University of Washington, USA.
Ruth KohenDepartment of Psychiatry and Behavioral Sciences, University of Washington, USA.
Julia Helen TracyDepartment of Psychiatry and Behavioral Sciences, University of Washington, USA.
Chuan ZhouSeattle Children's Research Institute, Center for Child Health, Behavior, and Development, USA.
Elizabeth McCauleyDepartment of Psychiatry and Behavioral Sciences, University of Washington, USA; Seattle Children's Research Institute, Center for Child Health, Behavior, and Development, USA.
Ann Vander StoepDepartment of Psychiatry and Behavioral Sciences, University of Washington, USA; Seattle Children's Research Institute, Center for Child Health, Behavior, and Development, USA.
Seattle Children's Hospital · USUniversity of Washington · USUniversity of California, Los Angeles · US

Funding

TRAINING THE SCIENCE OF CHILD MENTAL HEALTH TREATMENTT32MH073517 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMA JACOB, John C. Piacentini · 2006 to 2026
$5.2M
University of Washington Reproductive, Perinatal and Pediatric Epidemiology T32HD052462 · NICHD · UNIVERSITY OF WASHINGTON · PI HOLT, VICTORIA L · 2006 to 2017
$2.7M
Emergence:Co-occurring Depression/Externalizing ProblemsR01MH063711 · NIMH · UNIVERSITY OF WASHINGTON · PI VANDER STOEP, ANN · 2001 to 2005
$2.0M
Adolescent Psychopathology: Implications of Co-MorbidityR01MH079402 · NIMH · UNIVERSITY OF WASHINGTON · PI MCCAULEY, ELIZABETH, VANDER STOEP, ANN · 2008 to 2011
$1.8M
NY MOVES: Evaluating the Impact of New York’s Methadone Outreach VEhicleSR01DA063711 · NIDA · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Ashly Elizabeth Jordan, Noa Krawczyk · 2025 to 2026
$1.6M
NICHD NIH HHS T32 HD052462NIDA NIH HHS R01 DA063711NIDA NIH HHS R01 MH/DA63711NIMH NIH HHS R01 MH063711NIMH NIH HHS R01 MH079402NIMH NIH HHS T32 MH073517
6 · The paper itself

Abstract

objectiveThe objective of this study was to apply a Bayesian statistical analytic approach that minimizes multiple testing problems to explore the combined effects of chronic low familial support and variants in 12 candidate genes on risk for a common and debilitating childhood mental health condition.

methodBayesian mixture modeling was used to examine gene by environment interactions among genetic variants and environmental factors (family support) associated in previous studies with the occurrence of comorbid depression and disruptive behavior disorders youth, using a sample of 255 children.

resultsOne main effect, variants in the oxytocin receptor (OXTR, rs53576) was associated with increased risk for comorbid disorders. Two significant gene × environment and one signification gene × gene interactions emerged. Variants in the nicotinic acetylcholine receptor α5 subunit (CHRNA5, rs16969968) and in the glucocorticoid receptor chaperone protein FK506 binding protein 5 (FKBP5, rs4713902) interacted with chronic low family support in association with child mental health status. One gene × gene interaction, 5-HTTLPR variant of the serotonin transporter (SERT/SLC6A4) in combination with μ opioid receptor (OPRM1, rs1799971) was associated with comorbid depression and conduct problems.

conclusionsResults indicate that Bayesian modeling is a feasible strategy for conducting behavioral genetics research. This approach, combined with an optimized genetic selection strategy (Vrieze et al., 2012), revealed genetic variants involved in stress regulation (FKBP5, SERT × OPMR), social bonding (OXTR), and nicotine responsivity (CHRNA5) in predicting comorbid status.

Indexed as

Bayes TheoremGene-Environment InteractionAdolescentChildComorbidityDepressionEpistasis, GeneticFamilyFemaleGenetic Association StudiesGenotyping TechniquesHumansLogistic ModelsMaleMental DisordersRetrospective StudiesBayesian mixture modelingComorbidityDepressionDisruptive behaviorMarkov chain Monte Carlo

Identifiers

PMID26228411
PMCPMC4522042
OpenAlexW2127420837

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.