Evidence map›Paper›PMID 26228387›Full record

SynthesisWorld journal of surgical oncology2015

Phytoestrogens and risk of prostate cancer: a meta-analysis of observational studies.

Jinjing He, Shuai Wang, Mi Zhou, Weiwen Yu, Yuelong Zhang, Xiang He

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in World journal of surgical oncology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Pooled it
  2. Cancer mortality predictions for 2026 in selected Asian countries and Australia with focus on prostate cancer.European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) · 2026
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  18. LC-ESI-MS based characterisation of isoflavones in soybean (Journal of food science and technology · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jinjing HeDepartment of Ophthalmology, Affiliated Zhejiang Provincial People's Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China.
Shuai WangDepartment of Urology, Affiliated Zhejiang Provincial People's Hospital, School of Medicine, Zhejiang University, Shangtang Road 158, Hangzhou, 310014, Zhejiang Province, People's Republic of China. zjuwangs@gmail.com.
Mi ZhouDepartment of Urology, Affiliated Zhejiang Provincial People's Hospital, School of Medicine, Zhejiang University, Shangtang Road 158, Hangzhou, 310014, Zhejiang Province, People's Republic of China.
Weiwen YuDepartment of Urology, Affiliated Zhejiang Provincial People's Hospital, School of Medicine, Zhejiang University, Shangtang Road 158, Hangzhou, 310014, Zhejiang Province, People's Republic of China.
Yuelong ZhangDepartment of Urology, Affiliated Zhejiang Provincial People's Hospital, School of Medicine, Zhejiang University, Shangtang Road 158, Hangzhou, 310014, Zhejiang Province, People's Republic of China.
Xiang HeDepartment of Urology, Affiliated Zhejiang Provincial People's Hospital, School of Medicine, Zhejiang University, Shangtang Road 158, Hangzhou, 310014, Zhejiang Province, People's Republic of China.
Zhejiang University · CNZhejiang Provincial People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundEpidemiologic studies have reported various results relating phytoestrogens to prostate cancer (PCa). The aim of this study was to provide a comprehensive meta-analysis on the extent of the possible association between phytoestrogens (including consumption and serum concentration) and the risk of PCa.

methodsEligible studies were retrieved via both computer searches and review of references. The summary relative risk ratio (RR) or odds ratio (OR) and 95% confidence interval (CI) were calculated with random effects models.

resultsA total of 11 studies (2 cohort and 9 case-control studies) on phytoestrogen intake and 8 studies on serum concentration were included in the meta-analysis. The pooled odds ratio (OR) showed a significant influence of the highest phytoestrogens consumption (OR 0.80, 95% CI 0.70-0.91) and serum concentration (OR 0.83, 95% CI 0.70-0.99) on the risk of PCa. In stratified analysis, high genistein and daidzein intake and increased serum concentration of enterolactone were associated with a significant reduced risk of PCa. However, no significant associations were observed for isoflavone intake, lignans intake, or serum concentrations of genistein, daidzein, or equol.

conclusionsThe overall current literature suggests that phytoestrogen intake is associated with a decreased risk of PCa, especially genistein and daidzein intake. Increased serum concentration of enterolactone was also associated with a significant reduced risk of PCa. Further efforts should be made to clarify the underlying biological mechanisms.

Indexed as

Case-Control StudiesHumansMaleObservational Studies as TopicPhytoestrogensProstatic NeoplasmsRisk FactorsPhytoestrogens

Identifiers

PMID26228387
PMCPMC4521376
OpenAlexW2126339019

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.