ReviewCurrent neurology and neuroscience reports2015
The Neurobiological Grounding of Persistent Stuttering: from Structure to Function.
Review in Current neurology and neuroscience reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06809387 (Investigating the Supplementary Motor Area Role in Speech and Reading Fluency in PWS With rTMS), which is not on this map. Cited by 64 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating the Supplementary Motor Area Role in Speech and Reading Fluency in PWS With rTMS
Who cites it
64 citing papers in PubMed, 146 citations in OpenAlex.
- Trial
- Transcranial direct current stimulation over left inferior frontal cortex improves speech fluency in adults who stutter.Brain : a journal of neurology · 2018Trial
- Investigating the feasibility of using transcranial direct current stimulation to enhance fluency in people who stutter.Brain and language · 2017Trial
- Altered gray matter network segregation and disrupted interregional connectivity in children with persistent developmental stuttering: a graph-theoretical morphometric study.Brain imaging and behavior · 2026Article
- Reduced integrity in the frontal aslant tract's premotor connections is associated with dysfluency severity in stuttering.PNAS nexus · 2026Article
- Differences in Motor and Perceptual Sequence Learning Between People Who Stutter and People Who Do Not Stutter.PsyCh journal · 2026Article
- The Speech Network in Childhood Stuttering: Differences in Functional Connectivity of the Planning and Motor Loops.Neurobiology of language (Cambridge, Mass.) · 2026Article
- Cortical somatosensory responses evoked by orofacial skin stretch experimentally applied during speech movement planning in stuttering and nonstuttering adults.IBRO neuroscience reports · 2025Article
- Increased Callosal Thickness in Early Trained Opera Singers.Brain topography · 2025Article
- Contemporary clinical conversations about stuttering: What does brain imaging research mean to clinicians?International journal of speech-language pathology · 2025Article
- Article
- An fMRI study of initiation and inhibition of manual and spoken responses in people who stutter.Imaging neuroscience (Cambridge, Mass.) · 2025Article
- Stuttering: Our Current Knowledge, Research Opportunities, and Ways to Address Critical Gaps.Neurobiology of language (Cambridge, Mass.) · 2025Review
- Brain anatomy differences in Chinese children who stutter: a preliminary study.Frontiers in neurology · 2025Article
- Delayed auditory feedback increases speech production variability in typically fluent adults but has the opposite effect in stuttering adults.Frontiers in human neuroscience · 2025Article
- Electroencephalographic Classification Reveals Atypical Speech Motor Planning in Stuttering Adults.Journal of speech, language, and hearing research : JSLHR · 2024Article
- Knowns and unknowns about the neurobiology of stuttering.PLoS biology · 2024Article
- Speaking to a metronome reduces kinematic variability in typical speakers and people who stutter.PloS one · 2024Article
- No evidence of altered language laterality in people who stutter across different brain imaging studies of speech and language.Brain communications · 2024Article
- Psychedelics in developmental stuttering to modulate brain functioning: a new therapeutic perspective?Frontiers in human neuroscience · 2024Article
4 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neuroimaging and transcranial magnetic stimulation provide insights into the neuronal mechanisms underlying speech disfluencies in chronic persistent stuttering. In the present paper, the goal is not to provide an exhaustive review of existing literature, but rather to highlight robust findings. We, therefore, conducted a meta-analysis of diffusion tensor imaging studies which have recently implicated disrupted white matter connectivity in stuttering. A reduction of fractional anisotropy in persistent stuttering has been reported at several different loci. Our meta-analysis revealed consistent deficits in the left dorsal stream and in the interhemispheric connections between the sensorimotor cortices. In addition, recent fMRI meta-analyses link stuttering to reduced left fronto-parieto-temporal activation while greater fluency is associated with boosted co-activations of right fronto-parieto-temporal areas. However, the physiological foundation of these irregularities is not accessible with MRI. Complementary, transcranial magnetic stimulation (TMS) reveals local excitatory and inhibitory regulation of cortical dynamics. Applied to a speech motor area, TMS revealed reduced speech-planning-related neuronal dynamics at the level of the primary motor cortex in stuttering. Together, this review provides a focused view of the neurobiology of stuttering to date and may guide the rational design of future research. This future needs to account for the perpetual dynamic interactions between auditory, somatosensory, and speech motor circuits that shape fluent speech.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.