Trial reportSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association
Prospective trial in Saudi Arabia comparing the 14-day standard triple therapy with the 10-day sequential therapy for treatment of Helicobacter pylori infection.
Trial report in Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Evidence based guidelines for the treatment of Helicobacter pylori infection in Korea 2020.The Korean journal of internal medicine · 2021Guideline
- Evidence-Based Guidelines for the Treatment ofGut and liver · 2021Guideline
- Comparison of the efficacies of triple, quadruple and sequential antibiotic therapy in eradicating Helicobacter pylori infection: A randomized controlled trial.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2023Trial
- Comparison of 10 and 14 days of triple therapy versus 10 days of sequential therapy for Helicobacter pylori eradication: A prospective randomized study.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2018Trial
- Two-week triple therapy has a higher Helicobacter pylori eradication rate than 1-week therapy: A single-center randomized study.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationTrial
- The cost-effectiveness of sequential versus standard triple therapy forSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationTrial
- Persistence ofJournal of clinical medicine · 2026Article
- Eradication rates of Helicobacter pylori regimens and predictors of treatment failure: A multicenter real-world study in Saudi Arabia.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2026Article
- Towards EffectiveInternational journal of molecular sciences · 2025Review
- First-Line Levofloxacin-Based Triple Therapy Versus Standard Bismuth-Based Quadruple Therapy forHealth science reports · 2025Article
- Epidemiology, pathogenicity, risk factors, and management ofBiomolecules & biomedicine · 2024Review
- Sequential versus Standard Triple Therapy for First-LineAntibiotics (Basel, Switzerland) · 2024Review
- Eradication Rate and Factors InfluencingInternational journal of general medicine · 2024Article
- Efficacy of Sequential Therapy as the First-Line Treatment in the Eradication of Helicobacter pylori.Cureus · 2023Review
- Comparison between different first-line therapy protocols in eradicatingPrzeglad gastroenterologiczny · 2018Article
- Response to: Treatment prolongation or quadruple therapy:- Individualization by geographical region.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- A prospective trial in Saudi Arabia comparing the 14-day standard triple therapy with the 10-day sequential therapy for treatment of Helicobacter pylori infection: A further confirmation of "Geographic Weight".Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- One or two weeks of treatment with Helicobacter Pylori ''standard'' triple therapy in the year 2015?Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- Efficacy of a bismuth-based quadruple therapy regimen forSaudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
- Selecting the optimum first-line treatment for H. pylori eradication.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology AssociationArticle
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
aimsTreatment success for Helicobacter pylori infection in Saudi Arabia is relatively unexplored. This prospective study compared the efficacy of sequential versus standard triple therapy in curing H. pylori infections. PATIENTS AND
methodsEligible patients underwent upper endoscopy at a single center in Saudi Arabia from October 2011 to February 2014. Patients who tested positive for H. pylori infection were randomly assigned to sequential therapy or standard triple therapy. Sequential treatment: Esomeprazole (20 mg bid for 10 days), amoxicillin (1000 mg for 5 days), then clarithromycin 500 mg and tinidazole 500 mg; both bid for 5 days. Standard triple treatment: Esomeprazole 20 mg, clarithromycin 500 mg, and amoxicillin 1000 mg each bid for 14 days. After 6 weeks of treatment, patients were tested for cure using a validated urea breath test. Application of the E-test determined susceptibility of H. pylori to different antibiotics.
resultsOf the 115 patients who received sequential therapy, 93 completed treatment. In the triple-therapy arm, 103 of 117 patients completed treatment. The eradication rate was 58/93 (62.3%) with sequential therapy and 69/102 (67.6%) with standard triple therapy, P = 0.44. Risk ratio was 0.92 (95% CI; 0.75-1.13), and number needed to treat was 19. Overall primary resistance: Metronidazole (48.5%), clarithromycin (23.3%), amoxicillin (14.8%), levofloxacin (11.1%), and tetracycline (2.3%). Mild adverse events occurred in 35 and 17 patients in the sequential and standard therapy groups, respectively.
conclusionSequential and standard triple therapies were similarly effective at eradicating H. pylori in two-thirds of Saudi patients. Metronidazole and clarithromycin resistance to H. pylori strains was common.
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